Frank H. Burton, PhD

Adjunct Associate Professor, Department of Pharmacology

Frank H. Burton

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Adjunct Associate Professor, Department of Pharmacology

Faculty, MS and PhD Programs in Pharmacology

President & CSO, Psyncretis, Inc.


Research Summary/Interests

Frank obtained his Ph.D. at the University of North Carolina at Chapel Hill with Dr. Clyde Hutchison III, where Frank's invention of oligonucleotide-directed DNA synthesis & cloning techniques and his discovery of the mammalian LINES-1 (L1) repetitive DNA was cited in Dr. Hutchison's admission to the National Academy of Sciences.

Frank's postdoctoral work was with Drs. Greg Sutcliffe and Floyd Bloom at The Scripps Research Institute (TSRI) in La Jolla, California, where he invented "physiological engineering" with a cyclic AMP-elevating transgene and was co-designer of a genome-expression fingerprinting technique that led to the founding of Digital Gene Technologies, Inc., and Neurome, Inc., of San Diego.

Frank's faculty research in the Department of Pharmacology included the invention of "brain circuit-testing" and the first transgenic mouse model of Obsessive Compulsive Disorder (OCD), Tourette's Syndrome (TS), and trichotillomania (TTM) -- from which Dr. Burton's model of hyperglutamatergic corticostriatal circuitry in such disorders has stimulated the clinical validation of antiglutamatergic drugs for OCD and TTM.

Dr. Burton currently is a biotech, small pharma, & medtech inventor & entrepreneur who continues lecturing in our Department, maintains parallel academic affiliations with the Graduate Program in Neuroscience, The Masonic Cancer Center, and the Minnesota Supercomputer Institute, and retains a small University lab at the Minneapolis Medical Research Foundation (MMRF) in downtown Minneapolis' Hennepin County Medical Center (HCMC) to extend his academic research on:

  1. tic & compulsion circuitry & drug development
  2. cancer "bottleneck" genes
  3. supercomputer-aided design of abiogenic nucleic acids