Cara Skon-Hegg, PhD

Research Scientist, Whiteside Institute for Clinical Research, Medical School, Duluth Campus

Cara Skon-Hegg

Contact Info

Office Phone 218-726-8890

Research Scientist, Whiteside Institute for Clinical Research, Medical School, Duluth Campus

Postdoctoral Fellowship, Immunology and Human Genetics, Genentech, San Francisco, 2017

PhD, Microbiology, Immunology, and Cancer Biology, University of Minnesota Twin Cities, 2013

BA, Biology, St. Olaf College, 2005


Cara Skon Hegg is a Research Scientist with the Whiteside Institute for Clinical Research, a collaboration between Saint Luke’s Hospital and the University of Minnesota Medical School, Duluth campus. She trained at the University of Minnesota’s Center for Immunology in the Twin Cities gaining a Ph.D. in Microbiology, Immunology, and Cancer Biology and did her postdoc at Genentech in South San Francisco, CA. She has specific expertise in Immunology and Microbiology, with a focus on flow cytometry, aseptic tissue and cell culture, immune phenotyping, in vivo mouse models, infection models, and genomic techniques.

Professional Associations



1. Skon-Hegg C, Zhang J, Wu Z, Sagolla M, Ota N, Wuster A, Tom J, Ramamoorthi N, Caplazi P, Monroe J, Lee WP, and T. Behrens. LACC1 regulates TNF and IL-17 in mouse models of arthritis and inflammation. Journal of Immunology. 202 (1): 183-193. 2019.

2. Lee, J-Y, Skon CN, Lee Y-J, Oh S, Taylor J, Malhotra D, Jenkins M, Rosenfeld M, Hogquist K, and S Jameson. The transcription factor KLF2 restrains CD4+ T follicular helper cell differentiation. Immunity. 42: 1-13. 2015.

3. Skon CN, Lee J-Y, Anderson KG, Masopust D, Hogquist K, and S Jameson. Transcriptional downregulation of S1PR1 is required for establishment of resident memory CD8+ T cells. Nature Immunology. 14: 1285-93. 2013.

4. Anderson K, Sung H, Skon CN, Lefrancois L, Deisinger A, Vezys V, and D Masopust. Cutting edge: intravascular staining redefines lung CD8 T cell responses. Journal of Immunology. 189: 2702-6. 2012.

5. Hickman H, Li L, Reynoso G, Rubin E, Skon C, Mays J, Gibbs J, Schwartz O, Bennink J, and J Yewdell. Chemokines control naïve CD8+ T cell selection of optimal lymph node antigen presenting cells. Journal of Experimental Medicine. 208: 255-12. 2011.

6. Skon C and S Jameson. Fox factors fight over T cell quiescence. Nature Immunology News and Views. 12: 522-24. 2011.

7. Hensley S, Zanker D, Dolan B, David A, Hickman H, Embry A, Skon C, Grebe K, Griffin T, Chen W, Bennink J, and J Yewdell. Unexpected role for the immunoproteasome subunit LMP2 in antiviral humoral and innate immune responses. Journal of Immunology. 8: 4115-22. 2010.

8. Weinreich M, Takada K, Skon C, Reiner S, Jameson S, and K Hogquist. KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors. Immunity. 31: 122-30. 2009.

9. Hickman H, Takeda K, Skon C, Murray F, Hensley S, Loomis J, Barber G, Bennink J, and J Yewdell. Direct priming of anti-viral CD8+ T cells in the peripheral interfollicular region of lymph nodes.Nature Immunology. 9:155-65. 2008.

10. Sekine H, Ferreira R, Pan-Hammarstrom Q, Graham R, Ziemba B, Vries S, Liu J, Hippen K, Koeuth T, Ortmann W, Iwahori A, Elliott M, Offer S, Skon C, Du L, Novitzke J, Lee A, Zhao N, Tompkins J, Altshuler D, Gregersen P, Cunningham-Rundles C, Harris R, Her C, Nelson D, Hammarstrom L, Gilkeson G, and T Behrens. Role for Msh5 in the regulation of Ig class switch recombination. PNAS. 104: 7193-7198. 2007.