John W. Nichols, PhD

Adjunct Assistant Professor, Department of Biomedical Sciences

John W. Nichols

Contact Info

Adjunct Assistant Professor, Department of Biomedical Sciences


PhD, Toxicology, Oregon State University, 1987

MS, Fisheries Science, University of Washington, 1981

BA, Zoology, University of Washington, 1978

Summary

Awards & Recognition

Scientific and Technological Achievement Award, U.S. EPA, AA physiologically based toxicokinetic model for dietary uptake of hydrophobic organic compounds by fish,@ 2006 Superior Accomplishment Award, Mid-Continent Ecology Division, Duluth, 2004. For service as Acting Associate Director for Science. Scientific and Technological Achievement Award, U.S. EPA, APhysiologically based toxicokinetic model for maternal transfer of 2,3,7,8- tetrachlorodibenzo-p-dioxin in brook trout (Salvelinus fontinalis),@ 2000 Special Act Award, U.S. EPA, Session Chair, 5th NHEERL Symposium on Indicators in Risk Assessment, 2000

Professional Associations

Society of Toxicology; member, Biological Modeling Specialty Section Northland Chapter of the Society of Toxicology; Councilor Society of Environmental Toxicology and Chemistry Midwest Chapter of the Society of Environmental Toxicology and Chemistry

Research

Research Summary/Interests

Development of PBTK and bioenergetics-based models for fish and wildlife; use of microdialysis sampling methods to obtain in vivo metabolism information; development of systems models for compounds that act by endocrine disrupting modes of action

Publications

Nichols, J.W., Hoffman, A.D., Fitzsimmons, P.N., and Lien, G.J. 2008. Use of on-line microdialysis sampling to determine the in vivo rate of phenol glucuronidation in rainbow trout. Drug Metab. Disposit. 36:1406-1413.

Nichols, J.W., Hoffman, A.D., Fitzsimmons, P.N., and Lien, G.J. 2008. Quantification of phenol, phenyl glucuronide, and phenyl sulfate in the blood of unanesthetized rainbow trout by on-line microdialysis sampling.Toxicol Mech. Meth. 18:405-412.

Nichols, J., Erhardt, S., Dyer, S., James, M., Moore, M., Plotzke K., Segner, H., Schultz, I., Vasiluk, L., and Weisbrod, A. 2007. Workshop repo rt: Use of in vitro absorption, distribution, metabolism, and excretion (ADME) data in bioaccumulation assessments for f ish. Human Ecol. Risk Assess. 13:1164-1191.

Hornung, M., Cook, P., Fitzsimmons, P., Kuehl, D., and Nichols, J. 2007. Tissue distribution and metabolism of benzo[a]pyrene in embryonic and larval medaka (Oryzias latipes). Toxicol. Sci . 100:393-405.

Fitzsimmons, P.N., Lien, G.J., and Nichols, J.W. 2007. A compilation of in vitro rate and affinity values for xenobiotic biotransformation in fish, measured under physiological conditions. Comp. Biochem. Physiol.145(C):485-506.

Nichols, J.W., Fitzsimmons, P.N., and Burkhard, L.P. 2007. In vitro-in vivo extrapolation of hepatic biotransformation data for fish: II. Modeled effects on chemical bioaccumulation. Environ. Toxicol. Chem.26:1304-1319 .

Nichols, J.W., Schultz, I.R., and Fitzsimmons, P.N. 2006. In vitro-in vivo, extrapolation of hepatic metabolism data for fish: I. A review of methods and strategy for incorporating intrinsic clearance estimates into chemical kinetic models. Aquat. T oxicol. 78:74-90.

Nichols, J.W., Echols, K.R., Tillitt, D.E., Secord, A.L., and McCarty, J.P. 2004. Bioenergetics-based modeling of individual PCB congeners in nestling tree swallows from two contaminated sites on the upper Hudson River, NY . Environ. Sci. Technol. 38:6234-6239.

Echols, K.R., Tillitt, D.E., Nichols, J.W., Secord, A.L., and McCarty, J.P. 2004. Bioaccumulation of PCB congeners in nestling tree swallows (Tachycineta biocolor) on the Hudson River, NY. Concentrations, patterns and accumulation rates. Environ. Sci. Technol. 38:6240-6246.

Nichols, J.W., Fitzsimmons, P.N., Whiteman, F.W., Dawson, T.D., Babeu, L., and Juenemann, J. 2004. A physiologically based toxicokinetic model for dietary uptake of hydrophobic organic compounds by fish. I. Feeding studies with 2,2',5,5'-tetra chlorobiphenyl. Toxicol. Sci. 77:206-218.

Nichols, J.W., Fitzsimmons, P.N., and Whiteman, F.W. 2004. A physiologically based toxicokinetic model for dietary uptake of hydrophobic o rganic compounds by fish. II. Simulation of chronic do sing scenarios. Toxicol. Sci.. 77:219-229.