Kendall B. Wallace, PhD

Professor, Department of Biomedical Sciences

Kendall B. Wallace

Contact Info

kwallace@umn.edu

Office Phone 218-726-8899

Fax 218-726-8014

Office Address:
Department of Biomedical Sciences
259 SMed
1035 University Drive
Duluth, MN 55812

Post Doctorate, University of Iowa

PhD, Michigan State University, 1979

Summary

Professional Associations

Research

Research Summary/Interests

Toxicology; mechanisms by which foreign chemicals, including drugs, industrial, environmental and agrochemical compounds cause adverse human health effects. My primary focus is on the mitochondrion as a primary target or a critical factor in the pathogenesis of various chemical exposures. Current projects focus on modulating cancer causation or chemical toxicity by manipulating mitochondrial homeostasis and the role of mitochondrial epigenetics in the reprogramming of metabolic homeostasis as a compensatory survival response to mitochondrial toxicity.

Dr. Wallace is past president of the Society of Toxicology, the American Board of Toxicology, the Academy of Toxicological Sciences, the Mitochondrial Research Society and the ILSI Health and Environmental Sciences Institute and has served on various scientific panels for the National Institutes of Health, the U.S. Food and Drug Administration, and the U.S. Environmental Protection Agency 

Publications

See full list of publications at: PubMed

BOOKS:
Free Radical Toxicology: Target Organ Toxicology Series (ed., K.B. Wallace), Taylor & Francis (1997)

Molecular Biology of the Toxic Response (eds., A. Puga and K.B. Wallace) Taylor & Francis (1998)


BOOK CHAPTERS:

Wallace, K.B.“Species-Selective Toxicity of Organophosphorus Insecticides:A Pharmacodynamic Phenomenon.”(Chapter 4, pp 79-105.In:Organophosphates: Chemistry, Fate and Effects (eds., J.E. Chambers and P.E. Levi).Academic Press, Inc., San Diego, CA 1992.

Wallace, K.B. “ Oxygen Free Radical-Independent Generation of Aldehyde Products of Microsomal Lipid Peroxidation by Adriamycin.”(pp. 569-576In:Oxidative Damage & Repair:Chemical, Biological, and Medical Aspects (ed., K.J.A. Davies).Pergamon Press, Inc. 1992.

Wallace, K.B.“Free Radical-Mediated Chemical Cardiomyopathies.”(Chapter 11In:Free Radical Toxicology:The Target Organ Toxicology Series (ed., K.B. Wallace).Taylor and Francis 1997.

Wallace, K.B.“Doxorubicin-induced Mitochondrial Cardiomyopathy.”In:Mitochondria in Pathogenesis (eds., J.J. Lemasters and A.-L. Nieminen). Chapter 25, pp467-488. Kluwer Academic/Plenum Publishers, New York.2001.

Starkov, A. and Wallace, K.B.“Yin and Yang Mitochondrial ROS”In:Oxidative Stress, Disease and Cancer (ed., K. Singh), Chapter. 1, pp 1-60, Imperial College Press, London 2006.

Oliveira, P.J., Sardao, V.A., Wallace, K.B. “Cardiovascular Toxicology of Mitochondrial Origin”. In: Mitochondrial Dysfunction in Drug-induced Toxicity (eds. Y. Will & J.D. Dykens), John Wiley & Sons (Hoboken, NJ USA) 2008.

Copeland, W.C. and Wallace, K.B. “Mitochondrial Genomics and Targeted Toxicities; Molecular and Cellular Toxicology; Comprehensive Toxicology (3rd ed., Elsevier). (in press).

REVIEW ARTICLES

Wallace, K.B., Eells, J.T., Madeira, V.M.C., Cortopassi, G., and Jones, D.P. 1997 “Mitochondria-Mediated Cell Injury.” Fund. Appl. Toxicol. 38, 23-37.

Mileson, B.E., Chambers, J.E., Chen, W.L., Dettbarn, W., Ehrich, M., Eldefrasi, A.T., Gaylor, D.W., Hamernik, K., Hodgson, E., Karczmar, A.G., Padilla, S., Pope, C.N., Richardson, R.J., Saunders, D.R., Sheets, L.P., Sultatos, L.G., and Wallace, K.B. 1998 . Common Mechanism of Toxicity: A Case Study of Organophosphorus Pesticides. J. Toxicol. Sci. 41, 8-20.

Wallace, K.B and Starkov, A. 2000 . “Mitochondrial Targets of Drug Toxicity”. In: Annual Reviews of Pharmacology and Toxicology, vol. 40, 353-388.

Hollingworth, R.M., Bjeldanes, L.F., Bolger, M., Kimber, I., Meade, B.J., Taylor, S.L., and Wallace, K.B. 2003 . The safety of genetically modified foods produced through biotechnology. Toxicol. Sci. 71, 2-8.

Wallace, K.B. 2003 . “Doxorubicin-induced Cardiac Mitochondrionopathy.” Pharmacology & Toxicology 93, 105-115.

Berthiaume, J.M. and Wallace, K.B. 2007 . Adriamycin-induced oxidative mitochondrial cardiotoxicity. Cell Biol. Toxicol. 23, 15-25. 

Wallace, K.B. 2007. Adriamycin-induced interference with cardiac mitochondrial calcium Homeostasis. Cardiovasc. Toxicol. 7, 101-107.

Wallace, K.B. Mitochondrial Off-Targets of Drug Therapy. 2008. Trends in Pharmacological Sciences. 29, 361-366.

Holsapple, M.P. and Wallace, K.B. 2008. Dose response considerations in risk assessment - An overview of recent ILSI activities. Toxicol. Lett. 180, 85-92.

Leach, A.R., Wallace, K., Alepee, N., Daston, G., Humphris, C., Manou, I., Modi. S., Ringeissen, S., Whelan, M., and Kimber, I. 2012. Characterizing hepatic mitochondrial function as a model for systemic toxicity: A commentary. Toxicology 302, 1-4. 

Wallace, K.B. (2014). Drug-induced mitochondrial neuropathy in children: A conceptual framework for critical windows of development. J. Child Neurology 29, 1241-1248.

Wallace, K.B. (2015). Multiple targets for drug-induced mitochondrial toxicity. (Current Medicinal Chemistry, 22, in press).

Teaching

Teaching Areas

Medical Toxicology

Mentoring/Advising: undergraduates, graduates & post-doctoral fellows.