Sabrina M Scroggins, PhD
Assistant Professor, Department of Biomedical Sciences
Assistant Professor, Department of Biomedical Sciences
Faculty member of the Integrated Biosciences Graduate program and the Center for Immunology, Department of Biomedical Sciences
Postdoctoral Fellow, Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, 2013-2019. Mentor: Mark Santillan, MD, PhD
PhD, Interdisciplinary Program in Immunology Department of Pathology, University of Iowa, Iowa City, IA, 2013. Mentor: Annette Schlueter, MD, PhD
BS, Biology, East Central University, Ada, OK, 2007
AA (Certified), Drafting and Design-Mechanical Engineering, Pontotoc Technology Center, Ada, OK, 1999
My research program investigates the intersections between the worlds of perinatal biology and cellular immunology to identify and understand underlying mechanisms that contribute to the development of maternal diseases. My work currently focuses on identifying and developing novel, personalized cellular immunotherapy approaches to treat and prevent hypertensive diseases in pregnancy. Other work in the lab focuses on the impact of maternal diseases on the future health of mom. The development of safe, novel therapeutic interventions for maternal diseases are vital to improving women's health in both the short-term and the long-term.
Further, as an under-represented minority and a first-generation college graduate, teaching and inspiring others to go into science is a priority in my personal and professional lives. I have had exceptional mentors throughout my training. These mentors and the acceptance of my own personal journey has inspired me to seek opportunities to mentor other diverse learners throughout my career. I strive to provide the same high level of mentorship that I have received to those I train to ultimately provide a more inclusive and equitable representation in science and medicine.
Scroggins SM, Waldschmidt TJ, Legge KL, Schlueter AJ. (2009) Alleviation of acute graft- versus-host disease following regulatory dendritic cell treatment in young and older mice. Blood 114(22):1377.
Scott JA, Klutho PJ, Accaoui RE, Nguyen E, Venema AN, Xie L, Jiang S, Scroggins S, PrasadAM,LuczakED,LiW,GuanX,BacksJ,SchlueterAJ,WeissRM,MillerFJ,Anderson ME, Grumbach IM. (2013) The multifunctional Ca2+/calmodulin-dependent kinase II delta regulatesarteriogenesisinamousemodelofflow-mediatedremodeling.PlosOne 8(8):e71550. doi:10.1371/journal.pone.0071550.
Scroggins SM, Olivier AK, Meyerholz DK, Schlueter AJ. (2013) Characterization of Regulatory Dendritic Cells That Mitigate Acute Graft-versus-Host Disease in Older Mice Following Allogeneic Bone Marrow Transplantation. PLoS ONE 8(9):e75158. doi: 10.1371/journal.pone.0075158.
Santillan MK, Santillan DA, Scroggins SM, Min JY, Sandgren JA, Pearson NA, Leslie KK, Hunter SK, Zamba GK, Gibson-Corley KN, Grobe JL. Vasopressin in Preeclampsia: A Novel VeryEarlyHumanPregnancyBiomarkerandClinicallyRelevantMouseModel,Hypertension. 2014 July 7;64(4):852-9. doi: 10.1161/HYPERTENSIONAHA.114.03848.PMID:25001273.
Santillan MK, Pelham CJ, Ketsawatsomkron P, Santillan DA, Davis DR, Devor EJ, Gibson- Corley KN, Scroggins SM, Grobe JL, Yang B, Hunter SK, Sigmund CD. Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes, Physiol Rep. 2015 January 1;3(1):pii: e1257.PMID:25602015.
Sandgren JA, Scroggins SM, Santillan DA, Devor EJ, Gibson-Corley KN, Pierce GL, Sigmund CD, Santillan MK, Grobe JL. Vasopressin: the missing link for preeclampsia? American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2015 309(9): R1062-R1064. doi:10.1152/ajpregu.00073.2015.
Scroggins SM, Santillan DA, Lund JM, Sandgren JA, Krotz LK, Hamilton WS, Devor EJ, Davis HA, Pierce GL, Gibson-Corley KN, Sigmund CD, Grobe JL, Santillan MK. Elevated vasopressin in pregnant mice induces T-helper subset alterations consistent with human preeclampsia. Clin Sci (Lond). 2018 Feb 14;132(3):419-436. doi: 10.1042/CS20171059. PMID:29371289.
Sandgren JA, Deng G, Lingonegoro DW, Scroggins SM, Perschbacher KJ, Nair AR, NishimuraTE,ZhangSY,AgborLN,WuJing,KeenHL,NaberMC,PearsonNA,Zimmerman KA, Weiss RM, Bowdler NC, Usachev YM, Santillan DA, Potthoff MJ, Sigmund CD, Pierce GL,Gibson-CorleyKN,SantillanMK,GrobeJL.ArginineVasopressinInfusionisSufficientto Model Clinical Features of Preeclampsia in Mice. JCI Insight. 2018; 3(19):e99403. https://doi.org/10.1172/jci.insight.99403. PMID:30282823.
Devor EJ, Santillan DA, Scroggins SM, Warrier A, Santillan MK. Trimester-Specific Plasma ExosomemicroRNAExpressionProfilesinPreeclampsia.JMaternFetalNeonatalMed. Jan 2019;1-9. doi: 10.1080/14767058.2019.1569614. PubMed PMID:30700172.
Perschbacker K, Deng G, Sandgren J, Walsh J, Witcher P, Sapouckey S, Owens C, Yang Zhang S, Scroggins S, Pearson N, Devor E, Sebag J, Pierce G, Fisher R, Santillan D, SigmundC,Gibson-CorleyK,SantillanM,GrobeJ.ReducedmRNAexpressionofRegulator of G Protein Signaling-2 (RGS2) in the placenta is associated with human preeclampsia and sufficient to cause features of the disorder in mice. Hypertension. 2020 Feb;75(2):569-579. doi: 10.1161/HYPERTENSIONAHA.119.14056. PMID:31865781.
Gumusoglu SB, Qing Hing BW, Chilukuri AS, Dewitt JJ, Scroggins SM, Steven HE.Chronic Maternal Interleukin-17 and Autism-related Cortical Gene Expression, Neurobiology, and Behavior. Neuropsychopharmacology. 2020 Feb; 45:1008-1017.
- I assisted in designing key experiments, interpreting data, and manuscriptpreparation.
Nuckols VR, Holwerda SW, Luehrs RE, DuBose LE, Stroud AK, Brandt DS, Betz AM, Fiedorowicz JG, Scroggins SM, Santillan DA, Grobe JL, Sigmund CD, Santillan MK, Pierce GL. Beat-to-Beat Blood Pressure Variability in the First Trimester is Associated With the Development of Preeclampsia in a Prospective Cohort. Hypertension. 2020 Dec; 76;(6):1800-1807. doi.org/10.1161/HYPERTENSIONAHA.120.15019. PMID: 32951467.
Gumusoglu SB, Stevens HE, Chilukuri A, Hing B, Scroggins SM, Kundu S, Sandgren JA, Santillan MK, Santillan DA, Grobe JL. Altered offspring neurodevelopment in an arginine vasopressin preeclampsia model. Translational Psychiatry. 2021 Jan;11(79). https://doi.org/10.1038/s41398-021-01205-0.
Gumusoglu SB, Scroggins SM, Vignato J, Santillan DA, Santillan MK. The Serotonin-Immune Axis in Preeclampsia. Cur Hypertens Rep. 2021 Aug; 23(37). https://doi.org/10.1007/s11906-021-01155-4.
Devor EJ, Santillan DA, Warrier A, Scroggins SM, Santillan MK. Placenta-specific protein 1 (PLAC1) expression is significantly down-regulated in preeclampsia via a hypoxia-mediated mechanism. Journal of Maternal-Fetal & Neonatology Medicine. J Matern Fetal Neonatal Med. 2021 Sept 26; 1-7. doi: 10.1080/14767058.2021.1977792.
Cushen SC, Ricci CA, Bradshaw JL, Slilzer T, Blessing A, Sun J, Zhou Z, Scroggins SM, Santillan MK, Santillan DA, Phillips NR, Goulopoulou S. Reduced maternal circulating cell-free mitochondrial DNA is associated with the development of preeclampsia. JAHA. 2022 Jan 18; 11(2)e021726. doi: 10.1161/JAHA.121.021726.
Cowman W, Scroggins SM, Hamilton WS, Bowdler NC, Devor EJ, Santillan MK, Santillan DA. Association between plasma leptin and cesarean section after induction of labor: a case control study. BMC Pregnancy and Childbirth. 2022 Jan; 22:29. https://doi.org/10.1186/s12884-021-04372-6.