Bong Sook Jhun, PhD, FCVS

Assistant Professor of Medicine, Cardiology

Bong Sook Jhun

Contact Info

Office Address:
Cancer & Cardiovascular Research Building
4-129
2231 6th Street SE
Minneapolis, MN 55455

Mailing Address:
Lillehei Heart Institute
1st Floor Mailroom CCRB, 2812A
2231 6th Street SE
Minneapolis, MN 55455

Lab Address:
Cancer and Cardiovascular Research Building
4-230
2231 6th Street SE
Minneapolis, MN 55455

Administrative Assistant Name
Jane Hutchins-Peterson

Administrative Email
jhutchin@umn.edu

Assistant Professor of Medicine, Cardiology


PhD, Molecular/Cell Biology, School of Medicine Kyung Hee University, Seoul, Republic of Korea

Master's Degree, Biochemistry, Department of Chemistry, Kyung Hee University, Seoul, Republic of Korea

Bachelor's Degree, Chemistry, Department of Chemistry, Kyung Hee University, Seoul, Republic of Korea

Summary

Dr. Jhun received her Ph.D. degree from the Kyung Hee University School of Medicine in Seoul, Republic of Korea. She completed her postdoctoral training at Harbor-UCLA Medical Center and University of Rochester. Subsequently, she worked as an Instructor at Thomas Jefferson University and as an Assistant Professor at Rhode Island Hospital and Brown University. Dr. Jhun joined the University of Minnesota faculty in 2018 as an Assistant Professor at the Lillehei Heart Institute, Cardiovascular Division, Department of Medicine. Her research interests focus on the cellular signaling mechanisms underlying abnormal mitochondrial morphology and mitochondrial dysfunction that contributes to the development of heart failure.

Expertise

  • Gq protein-coupled receptor signaling
  • Mitochondrial signaling
  • Cardiomyocyte death
  • Cardiac fibroblast proliferation
  • Cardiac remodeling
  • Heart failure

Awards & Recognition

  • Fellow of Cardiovascular Section of American Physiological Society (2019)
  • Oral Abstract Award, Central Society for Clinical and Translational Research (2019)
  • Career Development Award, American Heart Association (2018)
  • New Investigator Award, American Physiological Society (2018)
  • Medical Research Grant Award, Rhode Island Foundation (2018)
  • Advance Clinical and Translational Research Pilot Projects Program Award, National Institute of General Medical Sciences (2017)

Professional Associations

  • American Physiological Society
  • International Society for Heart Research
  • American Heart Association
  • Biophysical Society
  • Cardiac Muscle Society
  • Central Society for Clinical and Translational Research

Research

Research Summary/Interests

Focus on the cellular signaling mechanisms underlying abnormal mitochondrial morphology and mitochondrial dysfunction that contributes to the cardiomyocyte death, cardiac fibroblast proliferation, and the development of heart failure. Elucidation of these regulatory mechanisms will facilitate the design of novel therapeutic targets for the pharmacological management of heart failure.

Research Funding Grants

  • COVID-19 Rapid Response Grant, Office of Academic Clinical Affairs, University of Minnesota Medical School, Jhun (PI), Use of PDE5 inhibitor for preventing cardiac damage by SARS-CoV-2 in COVID-19 patients with cardiopulmonary diseases, 06/10/2020 – 06/09/2021
  • R01HL148727, NIH/NHLBI, Choudhary (PI) & Jhun (Co-I), Role of Endothelial Anoctamin-1 in Pulmonary Arterial Hypertension, 07/01/2019 - 06/30/2024
  • 18CDA34110091, American Heart Association Summer 2018 Career Development Award, Jhun (PI), Role of PKD in right ventricular dysfunction during pulmonary arterial hypertension, 07/01/2018 - 06/30/2021
  • R01HL136757, NIH/NHLBI, O-Uchi (PI) & Jhun (Co-I), Regulation of mitochondrial calcium uniporter in the heart, 09/01/2017 - 05/31/2022
  • Group Program Grant, Institute of Engineering in Medicine, University of Minnesota, Dudley, O-Uchi, Talkachova (MPI) & Jhun (Co-I), Cardiac working group targeting multi-scale mechanisms of arrhythmia, 02/01/2019 - 01/31/2020

Publications

A complete list of publication can be found at NCBI

  • Adaniya SM, O-Uchi J, Cypress MW, Kusakari Y, Jhun BS#: Posttranslational Modifications of Mitochondrial Fission and Fusion Proteins in Cardiac Physiology and Pathophysiology. Am J Physiol Cell Physiol. 2019, 316(5): C583-C604. PMID: 30758993 (#Corresponding author)
  • Jhun BS#, O-Uchi J#, Adaniya SM, Mancini TJ, Cao JL, King ME, Landi AK, Ma H, Shin M, Yang D, Xu X, Yoon Y, Choudhary G, Clements RT, Mende U, Sheu SS#: Protein kinase D activation induces mitochondrial fragmentation and dysfunction in cardiomyocytes. ?J. Physiol. 2018, 596(5):827-855. PMCID: PMC5830422 (#Corresponding author)
  • Jhun BS*, Mishra J*, Hurst S, O-Uchi J, Csordás G, Sheu SS. The Mitochondrial Ca2+ uniporter: Structure, Function and Pharmacology. Handb Exp Pharmacol. 2017, 240:129-156. PMCID: PMC5554456 (*Equal contribution)
  • Jhun BS*, Mishra J*, Monaco S, Fu D, Jiang W, Sheu SS, O-Uchi J: The mitochondrial Ca2+ uniporter: Regulation by auxiliary subunits and signal transduction pathways. Am J Physiol Cell Physiol. 2016, 311(1):C67-80. PMCID: PMC4967134. (*Equal contribution)
  • Jhun BS*, O-Uchi Jin*, Xu S, Hurst S, Raffaello A, Liu X, Yi B, Zhang H, Gross P, Mishra J, Ainbinder A, Kettlewell S, Smith GL, Dirksen RT, Wang W, Rizzuto R, Sheu SS: Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter. Antioxid Redox Signal. 2014, 21(6):863-79. PMCID: PMC4116095 (*Equal contribution)
  • Jhun BS, Lee H, Jin ZG, Yoon Y: Glucose stimulation induces dynamic change of mitochondrial morphology to promote insulin secretion in the insulinoma cell line INS-1E. PLoS One. 2013, 8(4):e60810. PMCID: PMC3614983
  • Jhun BS*, O-Uchi Jin*, Wang W, Ha CH, Zhao J, Kim JY, Wong C, Dirksen RT, Lopes CM, Jin ZG: Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1. Circ Res. 2012, 110: 59-70. PMCID: PMC4232192 (*Equal Contribution)