Lin Yee Chen, MD, MS

Professor of Medicine, Cardiovascular Division

Lin Yee Chen

Contact Info

Mailing Address:
420 Delaware Street SE
MMC 508 Mayo
8508A (Campus Delivery Code)
Minneapolis, MN 55455

Administrative Assistant Name
Wendy Markuson

Administrative Email

Additional Locations

M Health Fairview Clinics & Surgery Center

Professor of Medicine, Cardiovascular Division

Director, Cardiac Electrophysiology Section

Faculty, PhD Program in Epidemiology

Faculty, MS in Clinical Research

Cardiac Electrophysiologist, Cardiologist

Medical School, National University of Singapore, Singapore

Residency, Mayo Clinic, Rochester, MN

Fellowship, Mayo Clinic, Rochester, MN

Master's Degree, University of Minnesota, Minneapolis, MN


I am a tenured Professor of Medicine, an ABIM board-certified cardiac electrophysiologist, and an NIH-funded clinical investigator. My research on atrial fibrillation (AF) is focused on 2 themes: (1) To discover novel strategies to prevent AF, reduce AF burden, and prevent AF-related outcomes, and (2) To characterize the relationship of AF to outcomes such as stroke, dementia, and sudden cardiac death, and to elucidate the underlying mechanisms. As an Atherosclerosis Risk in Communities (ARIC) and Multi-Ethnic Study of Atherosclerosis (MESA) investigator, I have published and co-authored numerous papers on AF using ARIC and MESA data. Currently, I am the PI of 2 NIH R01-funded projects: (1) a large multi-center project (R01HL126637) that uses the Zio XT Patch—an ambulatory heart rhythm monitor—to define the prevalence of subclinical AF in the elderly and elucidate the prognostic significance of subclinical AF and AF burden, (2) R01HL141288 which aims to clarify the role of underlying left atrial abnormality in determining AF-related related stroke and cognitive decline. Clinically, I provide comprehensive, evidence-based, and state-of-the-art care to patients with AF which includes performing catheter ablation to maintain sinus rhythm and left atrial appendage occlusion to prevent cardioembolic stroke.

Awards & Recognition

  • American Heart Association, 10SDG3420031, 2010-2015, Gene-Gene and Gene-Environment Interactions in Atrial Fibrillation
  • National Institute on Aging, R21AG042660, 2013-2016, Arterial Structure and Function and Atrial Fibrillation
  • National Heart, Lung, and Blood Institute, R01HL126637, 2016-2021, Significance of Atrial Fibrillation and Atrial Fibrillation Burden Detected by Novel ECG Monitoring in Community-Dwelling Elderly
  • AHC Faculty Research Development Award, 2017-2019, Moderate-Intensity Continuous Training and Sprint Interval Training in Reducing Atrial Fibrillation Burden
  • National Heart, Lung, and Blood Institute, R01HL141288, 2018-2022, Left Atrial Abnormality and Atrial Fibrillation-Related Cerebral Infarcts and Cognitive Decline

Professional Associations

  • Member - Management Committee, Cardiovascular Service Line, University of Minnesota Health Heart Care
  • Member - ECG & Arrhythmias Committee, Clinical Cardiology Council, American Heart Association
  • Member - Research Committee, Heart Rhythm Society
  • Member - Evidence Review Committee for the AHA/ACC 2016 Guideline for the Treatment of Syncope
  • Member - 2017 ACC/AHA/Heart Rhythm Society Guideline Focused Update on the Management of Patients With Atrial Fibrillation Writing Committee
  • Member - 2018 EHRA/HRS/APHRS/SOLAECE Expert Consensus on Arrhythmias and Cognitive Function: What is the best practice?


Research Summary/Interests

Care Philosophy
I believe in providing comprehensive and evidence-based cardiac electrophysiology care to my patients.

Research Funding Grants

Principal Investigator

  • NIH R01 HL126637 (2016-2021): Significance of Atrial Fibrillation and Atrial Fibrillation Burden Detected by Novel ECG Monitoring in Community-Dwelling Elderly
  • NIH R01 HL141288 (2018-2022): Left Atrial Abnormality and Atrial Fibrillation-Related Cerebral Infarcts and Cognitive Decline
  • Academic Health Faculty Research Development Grant (2017-2019): Moderate-Intensity Continuous Training and Sprint Interval Training in Reducing Atrial Fibrillation Burden


  • NIH R01 HL127659 (2015-2019): Atrial fibrillation burden, vascular disease of the brain and cardiac MRI in MESA
  • NIH R01 HL122200 (2015-2018): Comparative Effectiveness of Oral Anticoagulants in Atrial Fibrillation
  • NIH R21 AG058445 (2017-2019): Atrial fibrillation treatment in older adults


  • Chung MK, Eckhardt LL, Chen LY, Ahmed HM, Gopinathannair R, Joglar JA, Noseworthy PA, Pack QR, Sanders P, Trulock KM. Lifestyle and Risk Factor Modification for Reduction of Atrial Fibrillation. A Scientific Statement from the American Heart Association. Circulation 2020;141:00–00. DOI: 10.1161/CIR.0000000000000748
  • Gutierrez A, Norby FL, Maheshwari A, Rooney MR, Gottesman RF, Mosley TH, Lutsey PL, Oldenburg N, Soliman EZ, Alonso A, Chen LY. Association of Abnormal P wave Indices with Dementia and Cognitive Decline Over 25 Years: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS). J Am Heart Assoc 2019:8:e014553.
  • Berman JP,* Norby FL,* Mosley TM, Soliman EZ, Gottesman RF, Lutsey PL, Alonso A, Chen LY. Atrial Fibrillation and Brain MRI Abnormalities: the Atherosclerosis Risk in Communities (ARIC) Study. Stroke 2019 doi/10.1161/STROKEAHA.118.024143
  • January CT, Wann LS, Calkins H, Chen LY, Cigarroa JE, Cleveland JC Jr, Ellinor PT, Ezekowitz MD, Field ME, Furie KL, Heidenreich PA, Murray KT, Shea JB, Tracy CM, Yancy CW. 2019 AHA/ACC/HRS focused update of the 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. Circulation. 2019, doi: 10.1161/CIR.0000000000000665
  • Maheshwari A,* Norby FL,* Roetker NS, Soliman EZ, Koene RJ,* Rooney MR,* O’Neal WT, Shah AM, Claggett BL, Solomon SD, Alonso A, Gottesman RF, Heckbert SR, Chen LY. Refining Prediction of Atrial Fibrillation-Related Stroke Using the P2-CHA2DS2-VASc Score: the Atherosclerosis Risk in Communities (ARIC) study and Multi-Ethnic Study of Atherosclerosis (MESA). Circulation 2019;139(2):180-191.
  • Koene RJ,* Alraies MC,* Norby FL,* Soliman EZ, Maheshwari A,* Lip GYH, Alonso A, Chen LY. Relation of the CHA2DS2-VASc Score to Risk of Thrombotic and Embolic Stroke in Community-Dwelling Individuals without Atrial Fibrillation (From The Atherosclerosis Risk in Communities [ARIC] Study). Am J Cardiol. 2019:123(3):402-408.
  • Chen LY, Norby FL, Chamberlain AM, MacLehose RF, Bengtson LGS, Lutsey PL, Alonso A. CHA2DS2-VASc Score and Stroke Prediction in Atrial Fibrillation in Whites, Blacks, and Hispanics. Stroke 2018 Nov. doi: 10.1161/STROKEAHA.118.021453
  • Chen LY, Zmora R, Duval S, Chow LS, Lloyd-Jones DM, Schreiner PJ. Cardiorespiratory Fitness, Adiposity and Heart Rate Variability: The CARDIA Study. Medicine & Science in Sports & Exercise 2018; 51(3): 509-514
  • Zhang MJ,* Roetker NS, Folsom AR, Alonso A, Heckbert SR, Chen LY. Feasibility of Using a Leadless Patch Monitor in Community Cohort Studies: The Multiethnic Study of Atherosclerosis. Pacing Clin Electrophysiol 2018; 41(11):1389-1390



University of Minnesota Medical Center;University of Minnesota Physicians Heart at Fairvie

Board Certifications

  • Internal Medicine
  • Cardiology
  • Cardiac Electrophysiology

Clinical Interests

Atrial fibrillation ablation (pulmonary vein isolation); Biventricular ICD implantation; ICD implantation; PVC ablation; Supraventricular tachycardia ablation; Ventricular tachycardia ablation

Hospital Privileges

Fairview Lakes Medical Center; University of Minnesota Health Maple Grove Clinics; Fairview Ridges Hospital; Fairview Southdale Hospital; University of Minnesota Medical Center