Lin Yee Chen, MD, MS

Professor of Medicine, Cardiovascular Division

Lin Yee Chen

Contact Info

Mailing Address:
420 Delaware Street SE
MMC 508 Mayo
8508A (Campus Delivery Code)
Minneapolis, MN 55455

Administrative Assistant Name
Jessica Velguth

Administrative Email
kennedy7@umn.edu

Additional Locations

M Health Fairview Clinics & Surgery Center

Professor of Medicine, Cardiovascular Division

Director, Lillehei Heart Institute

Fred C. and Katherine B. Andersen Chair in Adult Cardiology

Faculty, PhD Program in Epidemiology

Faculty, MS in Clinical Research


Cardiac Electrophysiologist, Cardiologist


Medical School, National University of Singapore, Singapore

Residency, Mayo Clinic, Rochester, MN

Fellowship, Mayo Clinic, Rochester, MN

Master's Degree, University of Minnesota, Minneapolis, MN

Summary

Dr. Lin Yee Chen is the Director of the Lillehei Heart Institute, and the Fred C. and Katherine B. Andersen Chair.

I am a tenured Professor of Medicine, an ABIM board-certified cardiac electrophysiologist, and an NIH-funded clinician-investigator. My patient-oriented research on atrial fibrillation (AF) and atrial myopathy is focused on 2 themes: (1) To identify novel risk factors for AF and atrial myopathy, and discover new strategies to prevent both conditions, (2) To characterize the relationship of AF and atrial myopathy to cardiovascular and neurocognitive outcomes such as stroke and dementia, and to elucidate the underlying mechanisms. As an Atherosclerosis Risk in Communities (ARIC) and Multi-Ethnic Study of Atherosclerosis (MESA) investigator, I have published and co-authored numerous papers on AF and atrial myopathy using ARIC and MESA data. Currently, I am the PI of 4 NIH R01-funded projects, which are all focused on AF and atrial myopathy. In addition, I am PI of a K24 grant, an NIH grant that expands my capacity in mentoring junior clinicians and scientists who are conducting patient-oriented research in cardiovascular science. As a clinician, I provide compassionate, evidence-based, and state-of-the-art care to patients with arrhythmias, which includes performing catheter ablation to maintain sinus rhythm in patients with AF.

Awards & Recognition

  • American Heart Association, 10SDG3420031, 2010-2015, Gene-Gene and Gene-Environment Interactions in Atrial Fibrillation
  • National Institute on Aging, R21AG042660, 2013-2016, Arterial Structure and Function and Atrial Fibrillation
  • National Heart, Lung, and Blood Institute, R01HL126637, 2016-2023, Significance of Atrial Fibrillation and Atrial Fibrillation Burden Detected by Novel ECG Monitoring in Community-Dwelling Elderly
  • AHC Faculty Research Development Award, 2017-2019, Moderate-Intensity Continuous Training and Sprint Interval Training in Reducing Atrial Fibrillation Burden
  • National Heart, Lung, and Blood Institute, R01HL141288, 2018-2023, Left Atrial Abnormality and Atrial Fibrillation-Related Cerebral Infarcts and Cognitive Decline
  • National Heart, Lung, and Blood Institute, K24HL155813, 2021-2026, Mentoring and Research to Classify Atrial Cardiomyopathy
  • National Institute of Neurological Disorders and Stroke, RF1NS127266, 2022-2027, Cognitive Aging, Brain Morphology, and Arrhythmias in Hispanics/Latinos: Implications for Prevention and Management of Alzheimer's Disease-Related Dementias
  • National Heart, Lung, and Blood Institute, R01HL158022, 2022-2026, Glucose patterns and cardiac arrhythmias in older adults with diabetes

Professional Associations

  • Fellow of American Heart Association
  • Fellow of Heart Rhythm Society
  • Chair - 2018 American Heart Association Scientific Statement Writing Group | Atrial Fibrillation Burden: Moving Beyond Atrial Fibrillation as a Binary Entity
  • Member - 2019 American College of Cardiology/American Heart Association/Heart Rhythm Society Guideline Focused Update on the Management of Patients With Atrial Fibrillation Writing Committee
  • Vice Chair - 2020 American Heart Association Scientific Statement Writing Group | Lifestyle and Risk Factor Modification for Reduction of Atrial Fibrillation
  • Chair – 2022 International Society of Electrocardiology and the International Society for Holter and Noninvasive Electrocardiology | P Wave Parameters and Indices: A Critical Appraisal of Clinical Utility, Challenges, and Future Research

Research

Research Summary/Interests

Care Philosophy
I believe in providing comprehensive and evidence-based cardiac electrophysiology care to my patients.

Research Funding Grants

Principal Investigator

  • NIH R01 HL126637 (2016-2023): Significance of Atrial Fibrillation and Atrial Fibrillation Burden Detected by Novel ECG Monitoring in Community-Dwelling Elderly
  • NIH R01 HL141288 (2018-2023): Left Atrial Abnormality and Atrial Fibrillation-Related Cerebral Infarcts and Cognitive Decline
  • NIH K24 HL155813 (2021-26): Mentoring and Research to Classify Atrial Cardiomyopathy
  • NIH RF1NS127266, (2022-27), Cognitive Aging, Brain Morphology, and Arrhythmias in Hispanics/Latinos: Implications for Prevention and Management of Alzheimer's Disease-Related Dementias
  • NIH R01HL158022, (2022-26), Glucose patterns and cardiac arrhythmias in older adults with diabetes

Co-Investigator

  • NIH R01HL142599 (2018-2023): Subclinical Atrial Fibrillation and Supraventricular Ectopy in the Jackson Heart Study
  • NIH RF1AG067924 (2020-25): Integrating Alzheimer's disease GWAS with proteomic and metabolomic QTL data

Publications

Selected Recent Publications

  • Wang W, Zhang MJ, Inciardi RM, Norby FL, Johansen MC, Parikh R, Van’t Hof JR, Alonso A, Soliman EZ, Mosley TH, Gottesman RF, Shah AM, Solomon SD, Chen LY. Association of Echocardiographic Measures of Left Atrial Function and Size With Incident Dementia JAMA 2022;327(12):1138-1148.
  • Chen LY, Ribeiro ALP, Platonov PG, Cygankiewicz I, Soliman EZ, Gorenek B, Ikeda T, Vassilikos VP, Steinberg JS, Varma N, Bayes-de-Luna A, Baranchuk A. P Wave Parameters and Indices: A Critical Appraisal of Clinical Utility, Challenges, and Future Research—A Consensus Document Endorsed by the International Society of Electrocardiology and the International Society for Holter and Noninvasive Electrocardiology. Circ Arrhythm Electrophysiol. 2022;15:e010435.
  • Johansen MC, Wang W, Zhang MJ, Alonso A, Wong DF, Gottesman RF, Chen LY. Associations between atrial arrhythmias and brain amyloid deposition: The ARIC-PET Study. J Alzheimers Dis. 2022;86(1):43-48
  • Rooney MR, Norby FL,Maheshwari A, Lutsey PL, Dudley SC, Soliman EZ, Loehr LR, Mosley TH, Coresh J, Alonso A, Chen LY. Frequent Premature Atrial Contractions are Associated with Poorer Cognitive Function: the Atherosclerosis Risk in Communities (ARIC) Study. Mayo Clin Proc. 2021;96(5):1147-1156.
  • Harding BN, Norby FL, Heckbert SR, McKnight B, Psaty BM, Floyd JS, Chen LY. Longitudinal measures of blood pressure and subclinical atrial arrhythmias: The Multi-Ethnic Study of Atherosclerosis and the Atherosclerosis Risk in Communities Study. J Am Heart Assoc 2021;10(11):e020260.
  • Wang W, Norby FL, Zhang MJ, Reyes, JL, Shah AM, Soliman EZ, Lutsey PL, Alonso A, Solomon SD, Inciardi RM, Chen LY. Differences in Left Atrial Size and Function and Supraventricular Ectopy between Black and White Participants in the Atherosclerosis Risk in Communities (ARIC) Study: Implications for Atrial Fibrillation Risk. J Am Heart Assoc 2021 10(21):e021723.
  • Maheshwari A, Norby FL, Soliman EZ, Alonso A, Sotoodehnia N, Chen LY. Association of P-Wave Abnormalities with Sudden Cardiac and Cardiovascular Death: The Atherosclerosis Risk (ARIC) in Communities Study. Circ Arrhythm Electrophysiol 2021;14(2):e009314.
  • Kim ED, Soliman EZ, Coresh J, Matsushita K, Chen LY. Two-week burden of arrhythmias across chronic kidney disease severity in a large community-based cohort: The ARIC Study. J of American Society of Nephrology 2021;32(3): 629-638.
  • Norby FL, Alonso A, Rooney MR, Maheshwari A, Koene RJ, Zhang MJ, Soliman EZ, Loehr LR, Mosley TH, Gottesman RF, Coresh J, Chen LY. Association of Ventricular Arrhythmias with Dementia: The Atherosclerosis Risk in Communities (ARIC) Study. Neurology 2021;96(6):e926-e936.
  • Wang W, Norby FL, Rooney MR, Zhang M, Bernal AG, Garg P, Soliman EZ, Alonso A, Dudley SC, Lutsey PL, Chen LY. Association of Life’s Simple 7 with Atrial Fibrillation Burden in the Atherosclerosis Risk in Communities (ARIC) Study. Am J Cardiol 2020;S0002-9149(20)31008-0.
  • Maheshwari A, Norby FL, Roetker NS, Soliman EZ, Koene RJ, Rooney MR, O’Neal WT, Shah AM, Claggett BL, Solomon SD, Alonso A, Gottesman RF, Heckbert SR, Chen LY. Refining Prediction of Atrial Fibrillation-Related Stroke Using the P2-CHA2DS2-VASc Score: the Atherosclerosis Risk in Communities (ARIC) study and Multi-Ethnic Study of Atherosclerosis (MESA). Circulation 2019;139(2):180-191.

Clinical

Clinics

University of Minnesota Medical Center;University of Minnesota Physicians Heart at Fairvie

Board Certifications

  • Internal Medicine
  • Cardiology
  • Cardiac Electrophysiology

Clinical Interests

Atrial fibrillation ablation (pulmonary vein isolation); Biventricular ICD implantation; ICD implantation; PVC ablation; Supraventricular tachycardia ablation; Ventricular tachycardia ablation

Hospital Privileges

Fairview Lakes Medical Center; University of Minnesota Health Maple Grove Clinics; Fairview Ridges Hospital; Fairview Southdale Hospital; University of Minnesota Medical Center