Demetri Yannopoulos, MD

Born in London, UK, Dr. Yannopoulos received his M.D. from the University of Athens in Greece. He completed his medicine residency and general-cardiology fellowship at the University of Minnesota. Following an interventional-cardiology fellowship at Johns Hopkins University in Baltimore, Maryland, Dr. Yannopoulos joined the University of Minnesota faculty in 2008. In March 2010, he became the research director for interventional cardiology.

Dr. Yannopoulos is board-certified in internal medicine, cardiology, and interventional cardiology. His clinical interests include emergent cardiac care, coronary-artery disease, and congenital and peripheral intervention.

Dr. Yannopoulos’s research involves cardiopulmonary resuscitation, hypothermia, and myocardial salvage during acute coronary syndromes. He is considered an authority in cardiorespiratory interactions and hypothermia during CPR. His work in the laboratories of Dr. Keith Lurie (at the University of Minnesota) and Dr. Henry Halperin (at Johns Hopkins University) has helped change current CPR practices.

Dr. Yannopoulos is a member of the American Heart Association’s CPR guidelines-writing committee, and of the basic life support and research working-group subcommittees. He also serves on the organization committee for the AHA’s Resuscitation Science Symposium (ReSS), the largest international conference addressing CPR and emergent cardiac/trauma care.

Dr. Yannopoulos is the recipient of two American Heart Association Young Investigator awards (2005 and 2008), and has received AHA and NIH grant support for his work in CPR devices designed to improve bloodflow and clinical outcomes.

• UMN Dean’s Distinguished Research Leadership Award, 2015
• AHA Heart Association Heart & Stroke Hero Award, 2015
• AHA Young Investigator Award in Resuscitation Science Symposium: “The Effect of Achieving Return of Spontaneous Circulation on Mitochondrial Respiration Following Prolonged Cardiac Arrest” w /Timothy Matsuura”, 2014
• AHA Young Investigator Award in Resuscitation Science Symposium: “Sodium Nitroprusside-enhanced Cardiopulmonary Resuscitation Facilitates Intra-arrest Therapeutic Hypothermia in a Porcine Model of Prolonged Ventricular Fibrillation” w/ Guillaume Debaty”, 2014
• Cardiovascular Division Innovator Award, 2014
• AHA Young Investigator Award in Resuscitation Science Symposium: “Anesthetic Postconditioning with Sevoflurane during Cardiology Resuscitation Improves Cardiac Mitochondrial Function in a Pig Model of Cardiac Arrest” w/Timothy Matsuura”, 2013
• Dr. Marvin & Hadassah Bacaner Research Award, 2011
• AHA Young Investigator Award in Resuscitation Science Symposium: “Mechanical Post Conditioning with Chest Compression Pauses at the Initiation of CPR Prevents Neurological Dysfunction at 24 Hours in Pigs after 15 Minutes Untreated Ventricular Fibrillation”, 2011
• AHA Young Investigator Award in Resuscitation Science Symposium: “Effects of Timing of Intra-CPR and Post Resuscitation Hypothermia on Myocardial Infarction Size in a Porcine Model of Ischemic Cardiac Arrest”, November 13, 2010
• Best Resuscitation Abstract Award 2009 AHA Scientific Sessions: “Ventilation Rate and Use of the Impedance Threshold Device are Correlated with Hemodynamics During CPR in Human”, 2009
• AHA Young Investigator Award Recipient in Resuscitation Science Symposium: “Mechanism of Pressure Transfer from the Thorax to the Cranium During Application of Negative Intrathoracic Pressure”, 2009
• AHA Young Investigator Award Recipient. “Intra-CPR Hypothermia with and Without Volume Loading in an Ischemic Model of Cardiac Arrest”. Resuscitation Science Symposium, 2008
• Member of the AHA/ECC BLS and Research Working Group Subcommittees, 2007
• LW Miller award of clinical excellence and dedication to cardiovascular research, 2007
• AHA Young Investigator Award Recipient. “Intrathoracic Pressure Regulator During Continuous-Chest-Compression Advanced Cardiac Resuscitation Improves Vital Organ Perfusion Pressures in a Porcine Model of Cardiac Arrest”, 2005

Notable Leadership Roles

• Member of the AHA/ECC 2010 CPR and emergent cardiac care guidelines writing committee
• Member of the organization committee of the AHA, Resuscitation Science Symposium Conference (ReSS)
• Member of the AHA/ECC BLS and Research Working Group Subcommittees

• Aufderheide, T. P., Ii, E., Saleh, H. O., Gutterman, D. D., Weston, B. W., Pepe, P. E., Baker, J. E., Labinski, J., Debaty, G., Tang, L., Szabo, A., Kalra, R., Yannopoulos, D., & Colella, M. R. Change in Out-of-Hospital 12-lead ECG Diagnostic Classification Following Resuscitation from Cardiac Arrest. Resuscitation 2021, 169: P45-52
• Abrams, D., MacLaren, G., Lorusso, R., Price, S., Yannopoulos, D., Vercaemst, L., Belohlavek, J., Taccone, F. S., Aissaoui, N., Shekar, K., Garan, A. R., Uriel, N., Tonna, J. E., Jung, J. S., Takeda, K., Chen, Y. S., Slutsky, A. S., Combes, A., & Brodie, D. Extracorporeal cardiopulmonary resuscitation in adults: evidence and implications. Intensive care medicine 2021; 48: 1-15 PMID: 34505911 PMCID: PMC8429884
• Tsangaris, A., Alexy, T., Kalra, R., Kosmopoulos, M., Elliott, A., Bartos, J. A., & Yannopoulos, D. Overview of Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) Support for the Management of Cardiogenic Shock. Frontiers in cardiovascular medicine 2021, 8, 686558. PMID: 34307500 PMCID: PMC8292640 
• Yannopoulos, D., Bartos, J., Raveendran, G., Walser, E., Connett, J., Murray, T. A., Collins, G., Zhang, L., Kalra, R., Kosmopoulos, M., John, R., Shaffer, A., Frascone, R. J., Wesley, K., Conterato, M., Biros, M., Tolar, J., & Aufderheide, T. P. Advanced reperfusion strategies for patients with out-of-hospital cardiac arrest and refractory ventricular fibrillation (ARREST): a phase 2, single centre, open-label, randomised controlled trial. Lancet (London, England) 2020; 396(10265): 1807-1816
• Yannopoulos, D., Bartos, J. A., Aufderheide, T. P., Callaway, C. W., Deo, R., Garcia, S., Halperin, H. R., Kern, K. B., Kudenchuk, P. J., Neumar, R. W., & Raveendran, G. The Evolving Role of the Cardiac Catheterization Laboratory in the Management of Patients With Out-of-Hospital Cardiac Arrest: A Scientific Statement From the American Heart Association. Circulation 2019, 139(12): e530-e552
• Voicu, S., Sideris, G., Dillinger, J. G., Yannopoulos, D., Deye, N., Kang, C., Bonneau, M., Bartos, J., Kedra, A., Bailliart, S., Pasteur-Rousseau, A., Amah, G., Bonnin, P., Callebert, J., Henry, P., & Megarbane, B. Synchronized Pulsatile Flow With Low Systolic Output From Veno-Arterial Extracorporeal Membrane Oxygenation Improves Myocardial Recovery After Experimental Cardiac Arrest in Pigs. Artificial organs 2018; 42(6): 597-604
• Yannopoulos, D., Bartos, J. A., Raveendran, G., Conterato, M., Frascone, R. J., Trembley, A., John, R., Connett, J., Benditt, D. G., Lurie, K. G., Wilson, R. F., & Aufderheide, T. P. Coronary Artery Disease in Patients With Out-of-Hospital Refractory Ventricular Fibrillation Cardiac Arrest. Journal of the American College of Cardiology 2017; 70(9): 1109-1117
• Yannopoulos, D., Bartos, J. A., Martin, C., Raveendran, G., Missov, E., Conterato, M., Frascone, R. J., Trembley, A., Sipprell, K., John, R., George, S., Carlson, K., Brunsvold, M. E., Garcia, S., & Aufderheide, T. P. Minnesota Resuscitation Consortium's Advanced Perfusion and Reperfusion Cardiac Life Support Strategy for Out-of-Hospital Refractory Ventricular Fibrillation. Journal of the American Heart Association 2016; 5(6)
• Yannopoulos, D., Aufderheide, T. P., Abella, B. S., Duval, S., Frascone, R. J., Goodloe, J. M., Mahoney, B. D., Nadkarni, V. M., Halperin, H. R., O'Connor, R., Idris, A. H., Becker, L. B., & Pepe, P. E. Quality of CPR: An important effect modifier in cardiac arrest clinical outcomes and intervention effectiveness trials. Resuscitation 2015; 94:106-13
• Bartos, J. A., Debaty, G., Matsuura, T., & Yannopoulos, D. Post-conditioning to improve cardiopulmonary resuscitation. Current opinion in critical care 2014; 20(3): 242-9
• Segal, N., Yannopoulos, D., Mahoney, B. D., Frascone, R. J., Matsuura, T., Cowles, C. G., McKnite, S. H., & Chase, D. G. Impairment of carotid artery blood flow by supraglottic airway use in a swine model of cardiac arrest. Resuscitation 2012; 83(8): 1025-30
• Yannopoulos, D., Matsuura, T., Schultz, J., Rudser, K., Halperin, H. R., & Lurie, K. G. Sodium nitroprusside enhanced cardiopulmonary resuscitation improves survival with good neurological function in a porcine model of prolonged cardiac arrest. Critical care medicine 2011; 39(6): 1269-74
• Yannopoulos, D., Kotsifas, K., & Lurie, K. G. Advances in cardiopulmonary resuscitation. Heart failure clinics 2011, 7(2): 251-68
• Benditt DG, Goldstein M, Sutton R, Yannopoulos D. Dispatcher-directed, bystander-initiated cardiopulmonary resuscitation: A safe step, but only a first step, in an integrated approach to improving sudden-cardiac-arrest survival.Circulation 2010;121:10-13
• Yannopoulos D, Matsuura T, McKnite S, Goodman N, Idris A, Tang W, Aufderheide TP, Lurie KG. No assisted ventilation cardiopulmonary resuscitation and 24-hour neurological outcomes in a porcine model of cardiac arrest.Crit Care Med 2010;38:254-260
• Yannopoulos D, Zviman M, Castro V, Kolandaivelu A, Ranjan R, Wilson RF, Halperin HR. Intra-cardiopulmonary resuscitation hypothermia with and without volume loading in an ischemic model of cardiac arrest. Circulation 2009;120:1426-1435
• Wolckel WG, Yanopoulos D, Zielinski T, McKnite S, Lurie KG. Inspiratory impedance-threshold device rapidly reverses central arterial hypotension in spontaneously-breathing pigs suffering from heat shock. Aviat Space Environ Med 2008;79:743-748
• Lurie KG, Yannopoulos D, McKnite SH, Herman ML, Idris AH, Nadkarni VM, Tang W, Gabrielli A, Barnes TA, Metzger AK. Comparison of a 10-breaths-per-minute vs. a 2-breaths-per-minute strategy during cardiopulmonary resuscitation in a porcine model of cardiac arrest. Respir Care 2008;53:862-970
• Yannopoulos D, Kolandaivelu A, Ranjan R. Flow or no flow: That is the question! Crit Care Med 2008;36:1677-1678
• Yannopoulos D, Lurie KG, Sakaguchi S, Laura VanHeel, Benditt DG. Reduced atrial tachyarrhythmia susceptibility following upgrade of conventional implanted pulse generator to cardiac resynchronization therapy in patients with heart failure. JACC 2007;50:1246-2351
• Yannopoulos D. Subacute gastric perforation by a left-ventricular assist device. World J Gastroenterol 2007;13:3253-3254
• Yannopoulos D, Aufderheide TP. Use of the impedance threshold device (ITD). Resuscitation 2007;75:192-193
• Yannopoulos D, Aufderheide T. Acute management of sudden cardiac death in adults based upon the new CPR guidelines. Europace 2007;9:2-9
• Yannopoulos D, Metzger A, Mcknite S, Lurie KG. Intrathoracic pressure regulation improves 24-hour survival in a porcine model of hypovolemic shock. Anesth Analg 2007;104:157-162
• Yannopoulos D, Halperin HR. Cardiopulmonary resuscitation. In: Adult Clinical Cardiology Self-Assessment Program. Seventh Edition. Washington, DC:American College of Cardiology;2009:Chapter 15
• Metzger A, Yannopoulos D, Lurie KG. Instrumental management of CPR. In: Mebazaa A, Gheorghiade M, Zannad FM, Parillo JE, eds. Acute Heart Failure. London, UK:Springer;2008:809-818
• Yannopoulos D, Lurie KG. Cardiopulmonary resuscitation: New treatment guidelines and advances for the treatment of sudden cardiac arrest. In: Lu F, Benditt DG, eds. Cardiac Pacing and Defibrillation: Principle and Practice. Beijing, China: People’s Medical Publishing House;2008