Demetri Yannopoulos, MD

Born in London, UK, Dr. Yannopoulos received his M.D. from the University of Athens in Greece. He completed his medicine residency and general-cardiology fellowship at the University of Minnesota. Following an interventional-cardiology fellowship at Johns Hopkins University in Baltimore, Maryland, Dr. Yannopoulos joined the University of Minnesota faculty in 2008. In March 2010, he became the research director for interventional cardiology.

Dr. Yannopoulos is board-certified in internal medicine, cardiology, and interventional cardiology. His clinical interests include emergent cardiac care, coronary-artery disease, and congenital and peripheral intervention.

Dr. Yannopoulos’s research involves cardiopulmonary resuscitation, hypothermia, and myocardial salvage during acute coronary syndromes. He is considered an authority in cardiorespiratory interactions and hypothermia during CPR. His work in the laboratories of Dr. Keith Lurie (at the University of Minnesota) and Dr. Henry Halperin (at Johns Hopkins University) has helped change current CPR practices.

Dr. Yannopoulos is a member of the American Heart Association’s CPR guidelines-writing committee, and of the basic life support and research working-group subcommittees. He also serves on the organization committee for the AHA’s Resuscitation Science Symposium (ReSS), the largest international conference addressing CPR and emergent cardiac/trauma care.

Dr. Yannopoulos is the recipient of two American Heart Association Young Investigator awards (2005 and 2008), and has received AHA and NIH grant support for his work in CPR devices designed to improve bloodflow and clinical outcomes.

• AHA Young Investigator Award in Resuscitation Science Symposium: “Effects of Timing of Intra-CPR and Post Resuscitation Hypothermia on Myocardial Infarction Size in a Porcine Model of Ischemic Cardiac Arrest”, November 13, 2010
• Best Resuscitation Abstract Award 2009 AHA Scientific Sessions: “Ventilation Rate and Use of the Impedance Threshold Device are Correlated with Hemodynamics During CPR in Human”, 2009
• AHA Young Investigator Award Recipient in Resuscitation Science Symposium: “Mechanism of Pressure Transfer from the Thorax to the Cranium During Application of Negative Intrathoracic Pressure”, 2009
• AHA Young Investigator Award Recipient. “Intra-CPR Hypothermia with and Without Volume Loading in an Ischemic Model of Cardiac Arrest”. Resuscitation Science Symposium, 2008
• Member of the AHA/ECC BLS and Research Working Group Subcommittees, 2007
• LW Miller award of clinical excellence and dedication to cardiovascular research, 2007
• AHA Young Investigator Award Recipient. “Intrathoracic Pressure Regulator During Continuous-Chest-Compression Advanced Cardiac Resuscitation Improves Vital Organ Perfusion Pressures in a Porcine Model of Cardiac Arrest”, 2005

Notable Leadership Roles

• Member of the AHA/ECC 2010 CPR and emergent cardiac care guidelines writing committee
• Member of the organization committee of the AHA, Resuscitation Science Symposium Conference (ReSS)
• Member of the AHA/ECC BLS and Research Working Group Subcommittees

• Benditt DG, Goldstein M, Sutton R, Yannopoulos D. Dispatcher-directed, bystander-initiated cardiopulmonary resuscitation: A safe step, but only a first step, in an integrated approach to improving sudden-cardiac-arrest survival.Circulation 2010;121:10-13
• Yannopoulos D, Matsuura T, McKnite S, Goodman N, Idris A, Tang W, Aufderheide TP, Lurie KG. No assisted ventilation cardiopulmonary resuscitation and 24-hour neurological outcomes in a porcine model of cardiac arrest.Crit Care Med 2010;38:254-260
• Yannopoulos D, Zviman M, Castro V, Kolandaivelu A, Ranjan R, Wilson RF, Halperin HR. Intra-cardiopulmonary resuscitation hypothermia with and without volume loading in an ischemic model of cardiac arrest. Circulation 2009;120:1426-1435
• Wolckel WG, Yanopoulos D, Zielinski T, McKnite S, Lurie KG. Inspiratory impedance-threshold device rapidly reverses central arterial hypotension in spontaneously-breathing pigs suffering from heat shock. Aviat Space Environ Med 2008;79:743-748
• Lurie KG, Yannopoulos D, McKnite SH, Herman ML, Idris AH, Nadkarni VM, Tang W, Gabrielli A, Barnes TA, Metzger AK. Comparison of a 10-breaths-per-minute vs. a 2-breaths-per-minute strategy during cardiopulmonary resuscitation in a porcine model of cardiac arrest. Respir Care 2008;53:862-970
• Yannopoulos D, Kolandaivelu A, Ranjan R. Flow or no flow: That is the question! Crit Care Med 2008;36:1677-1678
• Yannopoulos D, Lurie KG, Sakaguchi S, Laura VanHeel, Benditt DG. Reduced atrial tachyarrhythmia susceptibility following upgrade of conventional implanted pulse generator to cardiac resynchronization therapy in patients with heart failure. JACC 2007;50:1246-2351
• Yannopoulos D. Subacute gastric perforation by a left-ventricular assist device. World J Gastroenterol 2007;13:3253-3254
• Yannopoulos D, Aufderheide TP. Use of the impedance threshold device (ITD). Resuscitation 2007;75:192-193
• Yannopoulos D, Aufderheide T. Acute management of sudden cardiac death in adults based upon the new CPR guidelines. Europace 2007;9:2-9
• Yannopoulos D, Metzger A, Mcknite S, Lurie KG. Intrathoracic pressure regulation improves 24-hour survival in a porcine model of hypovolemic shock. Anesth Analg 2007;104:157-162
• Yannopoulos D, Halperin HR. Cardiopulmonary resuscitation. In: Adult Clinical Cardiology Self-Assessment Program. Seventh Edition. Washington, DC:American College of Cardiology;2009:Chapter 15
• Metzger A, Yannopoulos D, Lurie KG. Instrumental management of CPR. In: Mebazaa A, Gheorghiade M, Zannad FM, Parillo JE, eds. Acute Heart Failure. London, UK:Springer;2008:809-818
• Yannopoulos D, Lurie KG. Cardiopulmonary resuscitation: New treatment guidelines and advances for the treatment of sudden cardiac arrest. In: Lu F, Benditt DG, eds. Cardiac Pacing and Defibrillation: Principle and Practice. Beijing, China: People’s Medical Publishing House;2008