Jop van Berlo, MD, PhD

Associate Professor of Medicine, Cardiovascular Division

Jop van Berlo

Contact Info

Fax 612-301-8298

Office Address:
Cancer & Cardiovascular Research Building
2231 6th Street SE
Minneapolis, Minnesota 55455

Mailing Address:
Lillehei Heart Institute
2231 6th Street SE
1st-floor Mailroom CCRB
Minneapolis, Minnesota 55455

Lab Address:
Cancer & Cardiovascular Research Building
2231 6th Street SE
Minneapolis, Minnesota 55455

Administrative Assistant Name
Esther Almeida

Administrative Email

Medical School, University of Maastricht, Maastricht, Netherlands

Residency, University Hospital Maastricht, Maastricht, Netherlands

Fellowship, Howard Hughes Medical Institute, Cincinnati, OH

PhD, University Maastricht and University Hospital, Maastricht, Netherlands


After obtaining his M.D. and Ph.D. degrees from the University of Maastricht, the Netherlands, Dr. Jop van Berlo performed postdoctoral research with Dr.Jeffery Molkentin at the Howard Hughes Medical Institute, Cincinnati Children’s Hospital Medical Center. Upon joining the University of Minnesota he has built a research program focused on the cellular and molecular mechanisms of cardiac remodeling and regeneration. An active area of research is on the role of the immune system in orchestrating cardiac remodeling. Separately, the laboratory is interested in discovering regulators of cardiomyocyte proliferation.

Awards & Recognition

  • 2017 Richard and Lois King Professorhip, Department of Medicine
  • 2017 Dr. Marvin and Hadassah Bacaner Research Award
  • 2017 The Hartwell Foundation Biomedical Research Award
  • 2013 Finalist Melvin L. Marcus Young Investigator Award 
  • 2012 NIH Pathway to Independence Award (K99/R00) from National Heart Lung and Blood Institute

Professional Associations

  • American Heart Association
  • International Society for Heart Research
  • American Physiological Society


Research Summary/Interests

My laboratory studies the cellular and molecular mechanisms of cardiac remodeling and regeneration. The goal of this research is to develop innovative strategies to enhance the limited ability of the heart to regenerate and stimulate reverse remodeling. To identify these strategies, we study the underlying mechanisms of endogenous remodeling and regeneration in mice. We are currently interested in discovering novel regulators of cardiomyocyte proliferation. We have candidate regulators that we are verifying in cell culture and in genetic mouse models. Furthermore, we are interested in the role of the immune system in orchestrating remodeling and regeneration.


A complete list of publication can be found at: berlo.1/bibliography/45984132/public/?sort=date&direction=ascending
or at:

  • Yellamilli A, Ren Y, McElmurry RT, Lambert JP, Gross P, Mohsin S, Houser SR, Elrod JW, Tolar J, Garry DJ, van Berlo JH. Abcg2-expressing side population cells contribute to cardiomyocyte renewal through fusion. FASEB j. 2020 Apr;34(4):5642-57
  • Dorn LE, Lasman L, Chen J, Xu X, Hund TJ, Medvedovic M, Hanna JH, van Berlo JH, Accornero F. Circulation 2019 Jan 22;139(4):533-45
  • Neidig LE, Weinberger F, Palpant NJ, Mignone J, Sorensen D, Martinson AM, Bender I, Nemoto N, Reinicke H, Pabon L, Molkentin JD, Murry CE, van Berlo JH. Evidence for minimal cardiogenic potential of Sca-1 positive cells in the adult mouse heart. Circulation 2018 Dec 18;138(25):2960-2
  • Chen Z, Zhu W, Bender I, Yellamilli A, Hodges TJ, Zhang J, Garry DJ, van Berlo JH. Pathologic stimulus determines lineage commitment of c-kit+ cardiac progenitor cells. Circulation. 2017 Dec 12;136(24):2359-72
  • Van Berlo JH and Molkentin JD. An Emerging Consensus on Cardiac Regeneration. Nat Med. 2014 Dec;20(12):1386-93
  • Van Berlo JH, Kanisicak O, Maillet M, Vagnozzi RJ, Karch J, Lin SC, Middleton RC, Marbán E, Molkentin JD. C-kit+ Cells Minimally Contribute Cardiomyocytes in the Heart. Nature. 2014 May 15;509(7500):337-41
  • Van Berlo JH, Maillet M, Molkentin JD. Signaling Effectors Underlying Pathologic Growth and Remodeling of the Heart. J Clin Invest. 2013 Jan;123(1):37-45



Identification of novel regulators of heart regeneration

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