Charles Lewis, MD

Assistant Professor, Department of Psychiatry and Behavioral Sciences

Charles Lewis

Contact Info

lewi1538@umn.edu

Office Phone 612-273-9040

Fax 612-273-9774

Administrative Assistant Name
Molly Jokimaki

Administrative Email
jokim004@umn.edu

MD, University of Texas Health Science Center at Houston

Psychiatry, Mayo School of Graduate Medical Education

Child and Adolescent Psychiatry, Mayo School of Graduate Medical Education

Clinician-Investigator Training Program, Mayo School of Graduate Medical Education

BA, Rice University

Summary

Dr. Lewis received his medical degree from the University of Texas Health Science Center at Houston. He then completed clinical training in psychiatry and child and adolescent psychiatry at the Mayo School of Graduate Medical Education, followed by a two-year clinical research fellowship. Dr. Lewis previously held positions as Assistant Professor of Psychiatry and Research Associate at the Mayo Clinic College of Medicine and Science. He joined the University of Minnesota Medical School faculty in 2019.

Professional Associations

  • American Psychiatric Association
  • American Academy of Child and Adolescent Psychiatry

Research

Research Summary/Interests

Dr. Lewis’ research focuses on the neurobiological correlates of suicidal behavior in adolescents with mood disorders, with the aims of improving risk assessment and identifying novel treatment approaches. His previous work has found impaired cortical inhibition, measured by transcranial magnetic stimulation (TMS), and alterations in excitatory neurotransmitter levels, measured by magnetic resonance spectroscopy, in youth with suicidal behavior. Dr. Lewis is also involved in ongoing projects utilizing noninvasive brain stimulation, including repetitive TMS, theta burst stimulation, and transcranial direct current stimulation (tDCS), as treatment interventions for children and adolescents with depression. 

Research Funding Grants

Dr. Lewis is the Alan G. Ross Memorial Investigator and recipient of a NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation, which supports his ongoing research on state-dependent impairment in cortical inhibition and network connectivity in adolescents with suicidal behavior. 

Publications

Peer-Reviewed Articles:

Sonmez AI, Kucuker MU, Lewis CP, Kolla BP, Doruk Camsari D, Vande Voort JL, Schak KM, Kung S, Croarkin PE. (2020). Improvement in hypersomnia with high frequency repetitive transcranial magnetic stimulation in depressed adolescents: preliminary evidence from an open-label study. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 97: 109763. doi: 10.1016/j.pnpbp.2019.109763.

Doruk Camsari D, Lewis CP, Sonmez AI, Nandakumar AL, Gresbrink MA, Daskalakis, ZJ, Croarkin PE. (2019). Transcranial magnetic stimulation markers of antidepressant treatment in adolescents with major depressive disorder. International Journal of Neuropsychopharmacology, 22: 435-444. doi: 10.1093/ijnp/pyz021.

Sonmez AI, Doruk Camsari D, Nandakumar AL, Vande Voort JL, Kung S, Lewis CP, Croarkin PE. (2019). Accelerated TMS for depression: a systematic review and meta-analysis. Psychiatry Research, 273: 770-781. doi: 10.1016/j.psychres.2018.12.041.

Lewis CP, Doruk Camsari D, Sonmez AI, Nandakumar AL, Gresbrink MA, Daskalakis ZJ, Croarkin PE. (2019). Preliminary evidence of an association between increased cortical inhibition and reduced suicidal ideation in adolescents treated for major depression. Journal of Affective Disorders, 244: 21-24. doi: 10.1016/j.jad.2018.09.079.

Blacker CJ, Lewis CP, Swintak CC, Bostwick JM, Rackley SJ. (2019). Medical student suicide rates: a systematic review of the historical and international literature. Academic Medicine, 94: 274-280. doi: 10.1097/ACM.0000000000002430.

Croarkin PE, Deng ZD, Nakonezny PA, Romanowicz M, Vande Voort JL, Camsari DD, Schak KM, Port JD, Lewis CP. (2018). High-frequency repetitive TMS for suicidal ideation in adolescents with depression. Journal of Affective Disorders, 239: 282-290. doi: 10.1016/j.jad.2018.06.048.

Balzekas I, Lewis CP, Shekunov J, Port JD, Jo HJ, Croarkin PE. (2018). A pilot study of GABAB correlates with resting-state functional connectivity in five depressed female adolescents. Psychiatry Research: Neuroimaging, 279: 60-63. doi: 10.1016/j.pscychresns.2018.05.013.

Lewis CP, Nakonezny PA, Blacker CJ, Vande Voort JL, Port JD, Worrell GA, Jo HJ, Daskalakis ZJ, Croarkin PE. (2018). Cortical inhibitory markers of lifetime suicidal behavior in depressed adolescents. Neuropsychopharmacology, 43: 1822-1831. doi: 10.1038/s41386-018-0040-x.

Blacker CJ, Lewis CP, Frye MA, Veldic M. (2017). Metabotropic glutamate receptors as emerging research targets in bipolar disorder. Psychiatry Research, 257: 327-337. doi: 10.1016/j.psychres.2017.07.059.

Lee JC, Lewis CP, Daskalakis ZJ, Croarkin PE. (2017). Transcranial direct current stimulation: considerations for research in adolescent depression. Frontiers in Psychiatry, 8: 91. doi: 10.3389/ fpsyt.2017.00091.

Lewis CP, Port JD, Frye MA, Vande Voort JL, Ameis SH, Husain MM, Daskalakis ZJ, Croarkin PE. (2016). An exploratory study of spectroscopic glutamatergic correlates of cortical excitability in depressed adolescents. Frontiers in Neural Circuits, 10: 98. doi: 10.3389/fncir.2016.00098.

Lewis CP, Nakonezny PA, Ameis SH, Vande Voort JL, Husain MM, Emslie GJ, Daskalakis ZJ, Croarkin PE. (2016). Cortical inhibitory and excitatory correlates of depression severity in children and adolescents. Journal of Affective Disorders, 190: 566-575. doi: 10.1016/j.jad.2015.10.020.

Croarkin PE, Nakonezny PA, Lewis CP, Zaccariello MJ, Huxsahl JE, Husain MM, Kennard BD, Emslie GJ, Daskalakis ZJ. (2014). Developmental aspects of cortical excitability and inhibition in depressed and healthy youth: an exploratory study. Frontiers in Human Neuroscience, 8: 669. doi: 10.3389/fnhum.2014.00669.

Book Chapters and Invited Reviews:

Kenney-Jung DL, Blacker CJ, Doruk Camsari D, Lee JC, Lewis CP. (2019). Transcranial direct current stimulation: mechanisms and psychiatric applications. Child and Adolescent Psychiatric Clinics of North America, 28: 53-60. doi: 10.1016/j.chc.2018.07.008.

Lee JC, Kenney-Jung DL, Blacker CJ, Doruk Camsari D, Lewis CP. (2019). Transcranial direct current stimulation in child and adolescent psychiatric disorders. Child and Adolescent Psychiatric Clinics of North America, 28: 61-78. doi: 10.1016/j.chc.2018.07.009.

Lewis CP, Farzan F, Croarkin PE. (2018). TMS in child and adolescent major depression. In Oberman LM and Enticott PG (Eds.) Neurotechnology and Brain Stimulation in Pediatric Psychiatric and Neurodevelopmental Disorders, pp. 147-188. London: Academic Press. doi: 10.1016/B978-0-12-812777-3.00007-6.  

Clinical

Board Certifications

  • Psychiatry - American Board of Psychiatry and Neurology 
  • Child Adolescent Psychiatry - American Board of Psychiatry and Neurology