Aaron Kerlin, PhD

Assistant Professor, Department of Neuroscience

Aaron Kerlin

Contact Info

akerlin@umn.edu

Office Phone 612-301-2650

Fax 612-626-6460

Lab Phone 612-626-0543

Assistant Professor, Department of Neuroscience


PhD, Neurobiology, Harvard University

BA, Neuroscience, Oberlin College

Summary

Expertise

Dendritic computations critical to learning

Research

Research Summary/Interests

As we learn a new skill, how does our brain change to store information about the actions involved? Cortical neurons receive information from the thousands of synaptic inputs onto the dendritic tree. Learning occurs when the efficacy of these inputs change in response to patterns of activity. Within the dendrite, location-dependent learning rules and interactions between inputs sculpt these changes.

The Kerlin Lab uses advanced two-photon microscopy techniques to understand how dendritic compartments and individual synapses within the motor cortex are modified as mice learn to perform new tasks. Recent work has identified a distinct loop between cortex and thalamus that maintains motor plans in the absence of overt action. By tracking and manipulating dendritic activity while monitoring the kinematics of action, we are determining the critical subcellular loci for the learning of new motor plans. Clarifying the biophysical events that drive normal plasticity will help us identify ways to shift cortical plasticity into regimes that favor the improvement of cognitive motor disorders or rehabilitation after damage to motor systems. 

Publications

Lu, R, Sun, W, Liang, Y, Kerlin, AM, Bierfeld, J, Seelig, JD, Wilson, DE, Scholl, B, Mohar, B, Tanimoto, M, Koyama, M, Fitzpatrick, D, Orger, MB & Ji, N 2017, 'Video-rate volumetric functional imaging of the brain at synaptic resolution' Nature Neuroscience, vol. 20, no. 4, pp. 620-628. https://doi.org/10.1038/nn.4516

Goldey, GJ, Roumis, DK, Glickfeld, LL, Kerlin, AM, Reid, RC, Bonin, V, Schafer, DP & Andermann, ML 2014, 'Removable cranial windows for long-term imaging in awake mice' Nature Protocols, vol. 9, no. 11, pp. 2515-2538. https://doi.org/10.1038/nprot.2014.165

Liu, R, Milkie, DE, Kerlin, AM, MacLennan, B & Ji, N 2014, 'Direct phase measurement in zonal wavefront reconstruction using multidither coherent optical adaptive technique' Optics Express, vol. 22, no. 2, pp. 1619-1628. https://doi.org/10.1364/OE.22.001619

Wang, C, Liu, R, Milkie, DE, Sun, W, Tan, Z, Kerlin, AM, Chen, TW, Kim, DS & Ji, N 2014, 'Multiplexed aberration measurement for deep tissue imaging in vivo' Nature Methods, vol. 11, no. 10, pp. 1037-1040. https://doi.org/10.1038/nmeth.3068

Andermann, ML, Kerlin, AM, Roumis, DK, Glickfeld, LL & Reid, RC 2011, 'Functional specialization of mouse higher visual cortical areas' Neuron, vol. 72, no. 6, pp. 1025-1039. https://doi.org/10.1016/j.neuron.2011.11.013

Bock, DD, Lee, WCA, Kerlin, AM, Andermann, ML, Hood, G, Wetzel, AW, Yurgenson, S, Soucy, ER, Kim, HS & Reid, RC 2011, 'Network anatomy and in vivo physiology of visual cortical neurons' Nature, vol. 471, no. 7337, pp. 177-184. https://doi.org/10.1038/nature09802

Kerlin, AM, Andermann, ML, Berezovskii, VK & Reid, RC 2010, 'Broadly Tuned Response Properties of Diverse Inhibitory Neuron Subtypes in Mouse Visual Cortex' Neuron, vol. 67, no. 5, pp. 858-871. https://doi.org/10.1016/j.neuron.2010.08.002

Andermann, ML, Kerlin, AM & Reid, RC 2010, 'Chronic cellular imaging of mouse visual cortex during operant behavior and passive viewing' Frontiers in Cellular Neuroscience, vol. 4, no. MAR, 3. https://doi.org/10.3389/fncel.2010.00003

Kerlin, AM & Lindsley, TA 2008, 'NeuroRhythmics: Software for analyzing time-series measurements of saltatory movements in neuronal processes' Journal of Neuroscience Methods, vol. 173, no. 1, pp. 147-152. https://doi.org/10.1016/j.jneumeth.2008.05.006

Lindsley, TA, Kerlin, AM & Rising, LJ 2003, 'Time-lapse analysis of ethanol's effects on axon growth in vitro.' Brain research. Developmental brain research, vol. 147, no. 1-2, pp. 191-199. https://doi.org/10.1016/j.devbrainres.2003.10.015