Effie Tsilibary, PhD

Associate Professor, Department of Neuroscience

Effie Tsilibary

Contact Info

tsili001@umn.edu

Office Phone 612-467-1466

Office Address:
321 Church St SE
6-145 Jackson Hall
Minneapolis, MN 55455-0250

Mailing Address:
Neuroscience
Room 6-145 JacH
1216A (Campus Delivery Code)
321 Church St SE
Minneapolis, MN 55455

Associate Professor, Department of Neuroscience


PhD, Cell Biology & Anatomy, University of California, San Francisco

MD, Medical School, National University of Athens, Greece

Summary

Research

Research Summary/Interests

My main research focuses on mechanisms leading to neuronal cell insult and loss in neurodegenerative conditions. I have worked with neuronal cell cultures and mouse models of Alzheimer’s disease (AD) and have developed new transgenic mice overexpressing in the brain a protein/enzyme (metalloproteinase-9) which protects against cognitive deficits by rescuing survival signaling pathways in cortical cells isolated from the AD mice.

To investigate in depth different mechanisms involved in neuronal cell dysfunction and loss in neurodegenerative conditions, I have developed a cell culture system using neuroblastoma and primary neuronal cells which are exposed to serum from patients with neurocognitive symptoms (patients with Gulf War Illness/GWI, multiple sclerosis/MS, subjects with cognitive decline, etc.), in order to examine serum-mediated adverse effects. These studies include the examination of signaling pathways important for cytoskeletal (Rho, -Rock, -LIM kinase signaling) and mitochondrial integrity (mitochondrial membrane potential), cell membrane integrity, etc. Main survival pathways mediated by growth factor receptors (TrkA, TrkB, IR, etc.) are also examined. The goal is: a) to identify potential pathogens in the serum of patients with neurocognitive symptoms; b) to eventually develop means to interfere with neuronal cell dysfunction and neuronal cell loss by preventing compromise of vital survival pathways for brain cells.

Research Methods/Techniques

Molecular mechanisms of cell-matrix interactions Cell signaling and survival in pathological conditions and neurodegenrative diseases

Publications

Kapodistria, K, Tsilibary, E-PC, Kotsopoulou, E, Moustardas, P & Kitsiou, P 2018, 'Liraglutide, a human glucagon-like peptide-1 analogue, stimulates AKT-dependent survival signalling and inhibits pancreatic ?-cell apoptosis' Journal of Cellular and Molecular Medicine, vol. 22, no. 6, pp. 2970-2980. https://doi.org/10.1111/jcmm.13259

Pijet, B, Stefaniuk, M, Kostrzewska-Ksiezyk, A, Tsilibary, E-PC, Tzinia, A & Kaczmarek, L 2018, 'Elevation of MMP-9 Levels Promotes Epileptogenesis After Traumatic Brain Injury' Molecular Neurobiology, vol. 55, no. 12, pp. 9294-9306. https://doi.org/10.1007/s12035-018-1061-5

Xidaki, D, Agrafioti, P, Diomatari, D, Kaminari, A, Tsalavoutas-Psarras, E, Alexiou, P, Psycharis, V, Tsilibary, EC, Silvestros, S & Sagnou, M 2018, 'Synthesis of hydroxyapatite, ?-Tricalcium phosphate and biphasic calcium phosphate particles to act as local delivery carriers of curcumin: Loading, release and in vitro studies' Materials, vol. 11, no. 4, 595. https://doi.org/10.3390/ma11040595

Kaminari, A, Tsilibary, E-PC & Tzinia, A 2018, 'A New Perspective in Utilizing MMP-9 as a Therapeutic Target for Alzheimer's Disease and Type 2 Diabetes Mellitus' Journal of Alzheimer's Disease, vol. 64, no. 1, pp. 1-16. https://doi.org/10.3233/JAD-180035

Kaminari, A, Giannakas, N, Tzinia, A & Tsilibary, E-PC 2017, 'Overexpression of matrix metalloproteinase-9 (MMP-9) rescues insulin-mediated impairment in the 5XFAD model of Alzheimer's disease' Scientific Reports, vol. 7, no. 1, 794. https://doi.org/10.1038/s41598-017-00794-5

Trohatou, O, Tsilibary, EF, Charonis, A, Iatrou, C & Drossopoulou, G 2017, 'Vitamin D3 ameliorates podocyte injury through the nephrin signalling pathway' Journal of Cellular and Molecular Medicine, vol. 21, no. 10, pp. 2599-2609. https://doi.org/10.1111/jcmm.13180

Papakonstantinou, VD, Lagopati, N, Tsilibary, EC, Demopoulos, CA & Philippopoulos, AI 2017, 'A Review on Platelet Activating Factor Inhibitors: Could a New Class of Potent Metal-Based Anti-Inflammatory Drugs Induce Anticancer Properties?' Bioinorganic Chemistry and Applications, vol. 2017, 6947034. https://doi.org/10.1155/2017/6947034

Katsoulieris, EN, Drossopoulou, GI, Kotsopoulou, ES, Vlahakos, DV, Lianos, EA & Tsilibary, E-PC 2016, 'High glucose impairs insulin signaling in the glomerulus: An in vitro and ex vivo approach' PLoS One, vol. 11, no. 7, e0158873. https://doi.org/10.1371/journal.pone.0158873

Dafnis, I, Argyri, L, Sagnou, M, Tzinia, A, Tsilibary, EC, Stratikos, E & Chroni, A 2016, 'The ability of apolipoprotein e fragments to promote intraneuronal accumulation of amyloid beta peptide 42 is both isoform and size-specific' Scientific Reports, vol. 6, 30654. https://doi.org/10.1038/srep30654

Kapodistria, K, Tsilibary, EP, Politis, P, Moustardas, P, Charonis, A & Kitsiou, P 2015, 'Nephrin, a transmembrane protein, is involved in pancreatic beta-cell survival signaling' Molecular and Cellular Endocrinology, vol. 400, pp. 112-128. https://doi.org/10.1016/j.mce.2014.11.003