Alessandro Magli, PhD

Assistant Professor of Medicine, Cardiovascular Division

Alessandro Magli

Contact Info

Mailing Address:
Cancer and Cardiovascular Research Building
2231 6th St SE
4-130
Minneapolis, MN

Lab Address:
Cancer and Cardiovascular Research Building
2231 6th St SE
4-240
Minneapolis, MN

Administrative Assistant Name
Jessica Wilde

Administrative Email
jabehm@umn.edu

Assistant Professor of Medicine, Cardiovascular Division

Faculty, Masters Program in Stem Cell Biology


PhD, University of Modena and Reggio Emilia, Italy

Master's Degree, University of Modena and Reggio Emilia, Italy

Bacherlor's Degree, University of Modena and Reggio Emilia, Italy

Summary

My research aims at understanding the molecular mechanisms at the basis of cell differentiation and stem cell maintenance, which play important roles during development and in tissue homeostasis. During both my graduate and post-graduate career, I tackled these questions by mainly focusing on the regulation of skeletal myogenic program. Using a combination of in vitro systems, animal models and primary biopsies, my work aims to identify 1) how gene expression is controlled at the epigenetic level, particularly through chromatin remodeling and looping; 2) the transcriptional and molecular networks contributing to diaphragm development and muscle stem cell homeostasis. Understanding the molecular regulation of embryonic and adult muscle stem/progenitor cells will be instrumental for the generation of improved cell-based therapies for muscle diseases, and for the development of novel animal models to study muscle regeneration and function.

Awards & Recognition

  • 2021 Invited for oral presentation at the Frontiers in Myogenesis Conference
  • 2019 Selected for oral presentation at the Gordon Research Conferences – Myogenesis
  • 2017 Selected for presentation at the online event “24 Hours of Stem Cells”
  • 2015 Awardee. Minnesota Regenerative Medicine Educational Grant
  • 2010 Travel Award. FASEB Summer Research Conferences
  • 2010 Finalist Visscher Symposium – University of Minnesota

Research

Publications

A complete list of publications can be found at:

https://www.ncbi.nlm.nih.gov/myncbi/1dCSctginiCAx/bibliography/public/

or at:

http://orcid.org/0000-0003-3874-2838

Selected publications:

  • Chow LS, Bosnakovski D, Mashek DG, Kyba M, Perlingeiro RCR, Magli A. Chromatin accessibility profiling identifies evolutionary conserved loci in activated human satellite cells. Stem Cell Res. 2021 Aug 11;55:102496. doi: 10.1016/j.scr.2021.102496. PubMed PMID: 34411972.
  • Zhang N, Mendieta-Esteban J, Magli A, Lilja KC, Perlingeiro RCR, Marti-Renom MA, Tsirigos A, Dynlacht BD. Muscle progenitor specification and myogenic differentiation are associated with changes in chromatin topology. Nat Commun. 2020 Dec 4;11(1):6222. doi: 10.1038/s41467-020-19999-w. PubMed PMID: 33277476
  • Magli A, Baik J, Pota P, Ortiz Cordero C, Kwak IY, Garry DJ, Love PE, Dynlacht BD, Perlingeiro RCR. Pax3 cooperates with Ldb1 to direct local chromosome architecture during myogenic lineage specification. Nat Commun. 2019 May 24;10(1):2316. doi: 10.1038/s41467-019-10318-6. PubMed PMID: 31127120.
  • Magli A, Baik J, Mills LJ, Kwak IY, Dillon BS, Mondragon Gonzalez R, Stafford DA, Swanson SA, Stewart R, Thomson JA, Garry DJ, Dynlacht BD, Perlingeiro RCR. Time-dependent Pax3-mediated chromatin remodeling and cooperation with Six4 and Tead2 specify the skeletal myogenic lineage in developing mesoderm. PLoS Biology. 2019 Feb 26;17(2):e3000153. doi: 10.1371/journal.pbio.3000153. eCollection 2019 Feb. PubMed PMID: 30807574.
  • Magli A, Incitti T, Kiley J, Swanson SA, Darabi R, Rinaldi F, Selvaraj S, Yamamoto A, Tolar J, Yuan C, Stewart R, Thomson JA, Perlingeiro RCR. PAX7 Targets, CD54, Integrin ?9?1 and SDC2, Allow Isolation of Human ES/iPS Cell-Derived Myogenic Progenitors. Cell Reports. 2017 Jun 27;19(13):2867-2877. doi: 10.1016/j.celrep.2017.06.005.