Lin Yee Chen, MD, MS

Professor of Medicine, Cardiovascular Division

Lin Yee Chen

Contact Info

Mailing Address:
420 Delaware Street SE
MMC 508 Mayo
8508A (Campus Delivery Code)
Minneapolis, MN 55455

Administrative Assistant Name
Wendy Markuson

Administrative Email
marku002@umn.edu

Additional Locations

M Health Fairview Clinics & Surgery Center

Professor of Medicine, Cardiovascular Division

Director, Cardiac Electrophysiology Section

Faculty, PhD Program in Epidemiology

Faculty, MS in Clinical Research


Cardiac Electrophysiologist, Cardiologist


Medical School, National University of Singapore, Singapore

Residency, Mayo Clinic, Rochester, MN

Fellowship, Mayo Clinic, Rochester, MN

Master's Degree, University of Minnesota, Minneapolis, MN

Summary

I am a tenured Professor of Medicine, an ABIM board-certified cardiac electrophysiologist, and an NIH-funded clinician-investigator. My patient-oriented research on atrial fibrillation (AF) and atrial cardiomyopathy is focused on 2 themes: (1) To identify novel risk factors for AF and atrial cardiomyopathy, and discover new strategies to prevent both conditions, (2) To characterize the relationship of AF and atrial cardiomyopathy to cardiovascular and neurocognitive outcomes such as stroke and dementia, and to elucidate the underlying mechanisms. As an Atherosclerosis Risk in Communities (ARIC) and Multi-Ethnic Study of Atherosclerosis (MESA) investigator, I have published and co-authored numerous papers on AF and atrial cardiomyopathy using ARIC and MESA data. Currently, I am the PI of 2 NIH R01-funded projects: (1) a large multi-center project (R01HL126637) that uses the Zio XT Patch—an ambulatory heart rhythm monitor—to define the prevalence of subclinical AF in older adults and clarify the prognostic significance of subclinical AF and AF burden, (2) R01HL141288 which aims to clarify the role of underlying left atrial abnormality in determining AF-related related stroke and cognitive decline. As a mentor, I am PI of K24HL155813, an NIH grant that expands my effort in mentoring junior clinicians and scientists who are conducting patient-oriented research in cardiovascular science. As a clinician, I provide compassionate, evidence-based, and state-of-the-art care to patients with arrhythmias, which includes performing catheter ablation to maintain sinus rhythm in patients with AF.

Awards & Recognition

  • American Heart Association, 10SDG3420031, 2010-2015, Gene-Gene and Gene-Environment Interactions in Atrial Fibrillation
  • National Institute on Aging, R21AG042660, 2013-2016, Arterial Structure and Function and Atrial Fibrillation
  • National Heart, Lung, and Blood Institute, R01HL126637, 2016-2022, Significance of Atrial Fibrillation and Atrial Fibrillation Burden Detected by Novel ECG Monitoring in Community-Dwelling Elderly
  • AHC Faculty Research Development Award, 2017-2019, Moderate-Intensity Continuous Training and Sprint Interval Training in Reducing Atrial Fibrillation Burden
  • National Heart, Lung, and Blood Institute, R01HL141288, 2018-2022, Left Atrial Abnormality and Atrial Fibrillation-Related Cerebral Infarcts and Cognitive Decline
  • National Heart, Lung, and Blood Institute, K24HL155813, 2021-26, Mentoring and Research to Classify Atrial Cardiomyopathy

Professional Associations

  • Fellow of American Heart Association
  • Fellow of Heart Rhythm Society
  • Chair - 2018 American Heart Association Scientific Statement Writing Group Atrial Fibrillation Burden: Moving Beyond Atrial Fibrillation as a Binary Entity
  • Member - 2019 American College of Cardiology/American Heart Association/Heart Rhythm Society Guideline Focused Update on the Management of Patients With Atrial Fibrillation Writing Committee
  • Vice Chair - 2020 American Heart Association Scientific Statement Writing Group Lifestyle and Risk Factor Modification for Reduction of Atrial Fibrillation

Research

Research Summary/Interests

Care Philosophy
I believe in providing comprehensive and evidence-based cardiac electrophysiology care to my patients.

Research Funding Grants

Principal Investigator

  • NIH R01 HL126637 (2016-2022): Significance of Atrial Fibrillation and Atrial Fibrillation Burden Detected by Novel ECG Monitoring in Community-Dwelling Elderly
  • NIH R01 HL141288 (2018-2022): Left Atrial Abnormality and Atrial Fibrillation-Related Cerebral Infarcts and Cognitive Decline
  • NIH K24 HL155813 (2021-26): Mentoring and Research to Classify Atrial Cardiomyopathy

Co-Investigator

  • NIH R01HL142599 (2018-2023): Subclinical Atrial Fibrillation and Supraventricular Ectopy in the Jackson Heart Study
  • NIH RF1AG067924 (2020-25): Integrating Alzheimer's disease GWAS with proteomic and metabolomic QTL data

Publications

Selected Recent Publications

  • Rooney MR, Norby FL, Maheshwari A, Lutsey PL, Dudley SC, Soliman EZ, Loehr LR, Mosley TH, Coresh J, Alonso A, Chen LY. Frequent Premature Atrial Contractions are Associated with Poorer Cognitive Function: the Atherosclerosis Risk in Communities (ARIC) Study. Mayo Clin Proc. 2021;96(5):1147-1156.
  • Norby FL, Alonso A, Rooney MR, Maheshwari A, Koene RJ, Zhang MJ, Soliman EZ, Loehr LR, Mosley TH, Gottesman RF, Coresh J, Chen LY. Association of Ventricular Arrhythmias with Dementia: The Atherosclerosis Risk in Communities (ARIC) Study. Neurology 2021;96(6):e926-e936. PMID: 33106393.
  • Rooney MR, Soliman EZ, Lutsey PL, Norby FL, Loehr LR, Mosley TH, Zhang M, Gottesman RF, Coresh J, Folsom AF, Alonso A, Chen LY. Prevalence and Characteristics of Subclinical Atrial Fibrillation in a Community-Dwelling Elderly Population: the Atherosclerosis Risk in Communities (ARIC) Study. Circ Arrhythm Electrophysiol 2019;12(10):e007390. PMID: 31607148PMCID: PMC6814387.
  • Maheshwari A, Norby FL, Roetker NS, Soliman EZ, Koene RJ, Rooney MR, O’Neal WT, Shah AM, Claggett BL, Solomon SD, Alonso A, Gottesman RF, Heckbert SR, Chen LY. Refining Prediction of Atrial Fibrillation-Related Stroke Using the P2-CHA2DS2-VASc Score: the Atherosclerosis Risk in Communities (ARIC) study and Multi-Ethnic Study of Atherosclerosis (MESA). Circulation 2019;139(2):180-191.
  • Chen LY, Chung MK, Allen LA, Ezekowitz M, Furie KL, McCabe P, Noseworthy PA, Perez MV, Turakhia MP. Atrial Fibrillation Burden: Moving Beyond Atrial Fibrillation as a Binary Entity. Circulation 2018; 137(20):e623-e644. 

Clinical

Clinics

University of Minnesota Medical Center;University of Minnesota Physicians Heart at Fairvie

Board Certifications

  • Internal Medicine
  • Cardiology
  • Cardiac Electrophysiology

Clinical Interests

Atrial fibrillation ablation (pulmonary vein isolation); Biventricular ICD implantation; ICD implantation; PVC ablation; Supraventricular tachycardia ablation; Ventricular tachycardia ablation

Hospital Privileges

Fairview Lakes Medical Center; University of Minnesota Health Maple Grove Clinics; Fairview Ridges Hospital; Fairview Southdale Hospital; University of Minnesota Medical Center