Mandy Liu, PhD

Assistant Professor of Medicine, Cardiovascular Division

Mandy Liu

Contact Info

Mailing Address:
CCRB
2231 6th Street SE
MMC 2812
Minneapolis, MN 55455

Administrative Assistant Name
Jane Hutchins-Peterson

Administrative Email
jhutchin@umn.edu

Assistant Professor of Medicine, Cardiovascular Division


PhD, Johann Wolfgang Goethe Universitaet, Frankfurt am Main, Germany

Master's Degree, Nankai University, Tianjin, China

Bachelor's Degree, Nankai University, Tianjin, China

Summary

I have a broad background in physiology, with specific training and expertise in research areas such as ion channel mechanisms, patch clamp electrophysiology, Mg homeostasis, mitochondria, and ER stress. I have carried out electrophysiological experiments to study nicotinic acetylcholine receptors at neuromuscular junctions, voltage-gated cardiac sodium channel and other cardiac ion channels. I have been working on different cardiac disease mouse models (hypertension, MI, HFpEF) and cell models (acutely isolated/cultured cardiomyocytes and human iPSC-derived cardiomyocytes). Recently, I am focusing on studying Mg deficiency-induced cardiac diastolic dysfunction (DD) and Mg supplementation on improvement of DD and HFpEF.

Expertise

  • Electrophysiology
  • Metabolic regulation of cardiac ion channels
  • Mg deficiency-induced DD, Mg homeostasis and Mg transporters
  • The UPR in ER stress and cardiac ion channel changes

Research

Research Summary/Interests

  • Mg deficiency-induced cardiac diastolic dysfunction and HFpEF

Research Funding Grants

Active Grants
  • UL1TR002494, University of Minnesota’s NIH Clinical and Translational Science Award on “Treatment of cardiac diastolic dysfunction with a mitoTEMPO analog”

Publications

  • Liu M., Liu H., Feng F., Xie A., Kang G-J, Zhao Y., Hou C.R., Zhou X., Dudley S.C., Jr. Magnesium deficiency causes a reversible metabolic diastolic cardiomyopathy. Accepted by J Am Heart Assoc on April 19 2021, JAHA/2020/020205R2.
  • Liu M, Liu H, Parthiban P, Kang GJ, Shi G, Feng F, Zhou A, Gu L, Karnopp C, Tolkacheva EC, Dudley SC Jr. Inhibition of the unfolded protein response reduces arrhythmic risk after myocardial infarction. J Clin Invest., 2021 published online https://doi.org/10.1172/JCI147836.
  • Liu M and Dudley SC Jr. Magnesium, oxidative stress, inflammation, and cardiovascular disease. Antioxidants, 2020, 9(10):907.
  • Liu M, Jeong E-M, Xie A, So EY, Shi G, Jeong JE, Zhou A, Dudley SC Jr. Magnesium supplementation improves diabetic mitochondrial and cardiac diastolic function, JCI Insight, 2019, 4(1):e123182. PMID: 30626750.
  • Liu M., Yang K-C., Dudley S.C., Jr. Cardiac sodium channel mutations: Why so many phenotypes? Nat Rev Cardiol., 2014, 11: 607-615. PMID: 24958080.

Teaching

Academic Interests and Focus

Physiology; Medical Biophysics

Clinical

Clinical Interests

Arrhythmia, Cardiac arrhythmia, Cardiac electrophysiology, Heart failure, Heart failure with preserved ejection fraction