Shernan Holtan, MD

Associate Professor of Medicine, Division of Hematology, Oncology and Transplantation

Shernan Holtan

Contact Info

Mailing Address:
420 Delaware Street SE
MMC 480
Minneapolis, MN 55455

Administrative Assistant Name
Kristin Blomquist

Administrative Phone

Administrative Email

Administrative Fax Number

Associate Professor of Medicine, Division of Hematology, Oncology and Transplantation

Medical Director, Clinical Trials Office Masonic Cancer Center Clinical Trials Office - Cell, Gene and Immunotherapy

Member, Masonic Cancer Center Executive Committee

Co-Chair, GVHD Cancer Center Translational Working Group

Director, Blood and Marrow Transplant Survivorship Clinic

Medical School, University of Nebraska, Omaha, NE

Residency, Mayo Clinic, Rochester, MN

Fellowship, Mayo Clinic, Rochester, MN


Dr. Holtan is an Associate Professor of Medicine in the Division of Hematology, Oncology, and Transplantation, where she serves as a hematologist focusing on allogeneic hematopoietic cell transplantation for malignant and non-malignant diseases, and long-term survivorship. Dr. Holtan brings a clinical/translational investigator focus on personalized immune monitoring, inflammation resolution, and the role of wound healing-associated growth factors in graft-versus-host disease. Her most recent research focuses on strength training and late effects related to transplantation. Dr. Holtan brings a strong track record of multidisciplinary research to the University of Minnesota.


  • Immunotherapy
  • Allogeneic hematopoietic cell transplantation
  • Graft versus host disease
  • Long-term survivorship
  • Strength Training

Awards & Recognition

  • Fellowship Academic Mentor of the Year (2016)
  • CIBMTR, member of Late Effects, Immunobiology, and GVHD working committees
  • OHSU Red Rose Award, 2013
  • Edward T. Creagan Award for Outstanding Contribution to Melanoma Research, 2011

Professional Associations

  • Co-Chair, BMT CTN 1703 Protocol Committee 2017-present
  • Member, BMT CTN Biomarkers Committee 2016-present
  • Member, BMT CTN 1501 Protocol Committee 2015-present
  • Member, American Society for Blood and Marrow Transplantation 2008-present
  • Member, American Society for Hematology 2008-present
  • Member, American Society for Clinical Oncology 2007-present
  • Member, Minnesota Medical Association 2003-present


Research Summary/Interests

  • Personalized immune monitoring
  • Inflammation resolution in GVHD
  • Immunology of pregnancy
  • Immunology of Cancer
  • Strength Training


Clinical Interests

BMT; cell therapy; GVHD; late effects