Wen Sheng, PhD

Assistant Professor of Medicine, Division of Infectious Diseases and International Medicine

Wen Sheng

Contact Info

Mailing Address:
689 SE 23rd Avenue
MC2821 Room 1-137
Microbiology Research Facility
Minneapolis, MN 55455

Lab Address:
689 SE 23rd Avenue
MC2821 Room 1-137
Microbiology Research Facility
Minneapolis, MN 55455

Administrative Assistant Name
IDIM Admin

Administrative Phone
612-624-9996

Administrative Email
idimadmin@umn.edu

Administrative Fax Number
612-625-4410

Assistant Professor of Medicine, Division of Infectious Diseases and International Medicine


Neurovirology


PhD, Virginia Polytechnic Institute and State University, Blacksburg, VA (1992)

Master's Degree, National Chung-Hsing University, Taiwan

Bachelor's Degree, National Chung-Hsing University, Taiwan

Summary

Wen Sheng obtained a PhD degree from the Virginia Polytechnic Institute and State University, Virginia and received post-doctoral training at the Minneapolis Medical Research Foundation. Dr. Sheng currently is involved in a program to investigate immune mechanisms that drive chronic retroviral infection-induced neuropathic pain in a model of distal symmetrical polyneuropathy (DSP) developed in animals with murine acquired immunodeficiency syndrome (MAIDS) and the effects of inflammatory modulation through cannabinoid receptor 2 (CB2R) in the context of peripheral neuropathy due to chronic retroviral infection.

Professional Associations

International Society for NeuroVirology (ISNV)

Research

Research Summary/Interests

Effects of inflammatory modulation through cannabinoid receptor 2 (CB2R) in the context of peripheral neuropathy due to chronic retroviral infection.

Research Funding Grants

Neuroimmune Approaches to Retrovirus Infection-induced Neuropathy via CB2Rs -- Dr. James Lokensgard.

Publications

  • Programmed death ligand-1 induction restrains the cytotoxic T lymphocyte response against microglia. Chauhan P, Hu S, Prasad S, Sheng WS, Lokensgard JR. Glia. 2021 Apr;69(4):858-871. 
  • Antiallodynic Effects of Cannabinoid Receptor 2 (CB2R) Agonists on Retrovirus Infection-Induced Neuropathic Pain. Sheng WS, Chauhan P, Hu S, Prasad S, Lokensgard JR. Pain Res Manag. 2019 Jul 4;2019:1260353.
  • Recall Responses from Brain-Resident Memory CD8+ T Cells (bTRM) Induce Reactive Gliosis. Prasad S, Hu S, Sheng WS, Chauhan P, Lokensgard JR. iScience. 2019 Oct 25;20:512-526.
  • Nitrosative damage during retrovirus infection-induced neuropathic pain. Chauhan P, Sheng WS, Hu S, Prasad S, Lokensgard JR. J Neuroinflammation. 2018 Mar 5;15(1):66.