Wen Sheng, PhD
Assistant Professor of Medicine, Division of Infectious Diseases and International Medicine
Contact Info
Assistant Professor of Medicine, Division of Infectious Diseases and International Medicine
Neurovirology
PhD, Virginia Polytechnic Institute and State University, Blacksburg, VA (1992)
Master's Degree, National Chung-Hsing University, Taiwan
Bachelor's Degree, National Chung-Hsing University, Taiwan
Summary
Wen Sheng obtained a PhD degree from the Virginia Polytechnic Institute and State University, Virginia and received post-doctoral training at the Minneapolis Medical Research Foundation. Dr. Sheng currently is involved in a program to investigate immune mechanisms that drive chronic retroviral infection-induced neuropathic pain in a model of distal symmetrical polyneuropathy (DSP) developed in animals with murine acquired immunodeficiency syndrome (MAIDS) and the effects of inflammatory modulation through cannabinoid receptor 2 (CB2R) in the context of peripheral neuropathy due to chronic retroviral infection.
Professional Associations
International Society for NeuroVirology (ISNV)
Research
Research Summary/Interests
Effects of inflammatory modulation through cannabinoid receptor 2 (CB2R) in the context of peripheral neuropathy due to chronic retroviral infection.
Research Funding Grants
Neuroimmune Approaches to Retrovirus Infection-induced Neuropathy via CB2Rs -- Dr. James Lokensgard.
Publications
- Programmed death ligand-1 induction restrains the cytotoxic T lymphocyte response against microglia. Chauhan P, Hu S, Prasad S, Sheng WS, Lokensgard JR. Glia. 2021 Apr;69(4):858-871.
- Antiallodynic Effects of Cannabinoid Receptor 2 (CB2R) Agonists on Retrovirus Infection-Induced Neuropathic Pain. Sheng WS, Chauhan P, Hu S, Prasad S, Lokensgard JR. Pain Res Manag. 2019 Jul 4;2019:1260353.
- Recall Responses from Brain-Resident Memory CD8+ T Cells (bTRM) Induce Reactive Gliosis. Prasad S, Hu S, Sheng WS, Chauhan P, Lokensgard JR. iScience. 2019 Oct 25;20:512-526.
- Nitrosative damage during retrovirus infection-induced neuropathic pain. Chauhan P, Sheng WS, Hu S, Prasad S, Lokensgard JR. J Neuroinflammation. 2018 Mar 5;15(1):66.