Wen Sheng, PhD
Assistant Professor of Medicine, Division of Infectious Diseases and International Medicine
Contact Info
Assistant Professor of Medicine, Division of Infectious Diseases and International Medicine
Neurovirology
PhD, Virginia Polytechnic Institute and State University, Blacksburg, VA (1992)
Master's Degree, National Chung-Hsing University, Taiwan
Bachelor's Degree, National Chung-Hsing University, Taiwan
Summary
Wen Sheng obtained a PhD degree from the Virginia Polytechnic Institute and State University, Virginia and received post-doctoral training at the Minneapolis Medical Research Foundation. Dr. Sheng currently is involved in a program to investigate immune mechanisms that drive chronic retroviral infection-induced neuropathic pain in a model of distal symmetrical polyneuropathy (DSP) developed in animals with murine acquired immunodeficiency syndrome (MAIDS) and the effects of inflammatory modulation through cannabinoid receptor 2 (CB2R) in the context of peripheral neuropathy due to chronic retroviral infection.
Professional Associations
International Society for NeuroVirology (ISNV)
Research
Research Summary/Interests
Effects of inflammatory modulation through cannabinoid receptor 2 (CB2R) in the context of peripheral neuropathy due to chronic retroviral infection.
Research Funding Grants
Neuroimmune Approaches to Retrovirus Infection-induced Neuropathy via CB2Rs -- Dr. James Lokensgard.
Publications
- The PD-1: PD-L1 pathway promotes development of brain-resident memory T cells following acute viral encephalitis. Prasad S, Hu S,Sheng WS, Chauhan P, Singh A, Lokensgard JR. J Neuroinflammation. 2017 Apr 13;14(1):82.
- Modulation of Microglial Cell Fc? Receptor Expression Following Viral Brain Infection. Chauhan P, Hu S,Sheng WS, Prasad S, Lokensgard JR. Sci Rep. 2017 Feb 6;7:41889.
- Glial cell activation, recruitment, and survival of B-lineage cells following MCMV brain infection. Lokensgard JR, Mutnal MB, Prasad S, Sheng WS, Hu S. J Neuroinflammation. 2016 May 20;13(1):114.
- Sheng WS, Hu S, Feng A, Rock RB. Reactive oxygen species from human astrocytes induced functional impairment and oxidative damage. Neurochem Res. 2013;38(10):2148-59.
- Sheng WS, Hu S, Min X, Cabral GA, Lokensgard JR, Peterson PK. The synthetic cannabinoid WIN55,212-2 inhibits generation of inflammatory mediators by IL-1?-stimulated human astrocytes. Glia 2005; 49: 211-219.