Julia Davydova
,
Credentials
MD, PhD

Associate Professor, Basic & Translational Research
Biography

Bio

Dr. Davydova is an Associate Professor at the Department of Surgery at the University of Minnesota (UMN). She is also a faculty member at the UMN Institute for Molecular Virology, Masonic Cancer Center, Center for Genome Engineering, and MD/PhD Medical Scientist Training Program. 

Dr. Davydova has over 20 years of experience in the field of gene therapy and cancer research. As a member of the Gene Therapy Center at the University of Alabama at Birmingham (UAB), she was directly involved in the development of first generations of adenoviral vectors for malignant diseases and establishment of standardized procedures for virus manufacturing. Her scientific contribution has resulted in developing critical elements to improve infectivity and specificity of adenovirus-based vectors which extended their utility for human gene therapy. 

Since joining the Department of Surgery and the Masonic Cancer Center at the UMN in 2006, Dr. Davydova’s research is focused on the clinical translation of adenovirus-based technologies for cancer patients. Her work with a focus on oncolytic adenovirus-mediated therapies for pancreatic cancer was funded by multiple awards including two NIH R01 grants.  

Dr. Davydova is a member of several professional societies, including American Society of Gene and Cell Therapy, American Association of Cancer Research, American Pancreatic Association and serves as an Academic and/or Guest editor in professional journals. She is also actively participating as a reviewer at multiple NIH study sections (e.g., Translational Immuno-Oncology (TIO), Radiation Therapeutics and Biology (RTB), Clinical and Translational Exploratory/Developmental Studies) and many international grant review panels. 

Dr. Davydova is a productive mentor to numerous laboratory trainees at different levels including undergrad and graduate students, medical scholars, postdoctoral fellows, surgical residents, and junior faculty.

Education

Dr. Davydova received her M.D. and Ph.D. in Pathophysiology and Molecular Biology from the Siberian State Medical University in Tomsk, Russia. In 2000, she was invited to join the Gene Therapy Center at the University of Alabama at Birmingham (UAB), where she obtained extensive training in virus-based gene therapy and cancer research.

Research Summary

Dr. Davydova’s current goals are focused on the clinical translation of oncolytic adenovirus for cancer patients, including patients with pancreatic, breast, melanoma, and sarcoma malignances. 

Her research focus includes but is not limited to:

  • Development of oncolytic adenovirus as a platform for cancer therapy and imaging. 
  • Development of novel virus-based immunotherapies for cancer patients.
  • Clinical translation of oncolytic adenovirus from “bench to bed”. 
  • Development of immunocompetent preclinical models for oncolytic virus therapy and cancer research. 

Selected Publications

  • Osipov, I. D., Vaskihovskaia, V. A., Zabelina, D. S., Kutseikin, S. S., Grazhdantseva, A. A., Kochneva, G. V., Davydova, J., Netesov, S. V., Romanenko, M. V. (2023). Development of Oncolytic Vectors Based on Human Adenovirus Type 6 for Cancer Treatment. Viruses 2023, 15 (1), 182.  doi: 10.3390/v1510182
  • Romanenko, M., Osipov, I., Netesov, S. V., Davydova, J. (2021). Adenovirus Type 6: Subtle Structural Distinctions from Adenovirus Type 5 Result in Essential Differences in Properties and Perspectives for Gene Therapy. Pharmaceutics, 13(10). PMID: 34683934 PMCID: PMC8540711 doi: 10.3390/pharmaceutics13101641
  • Robertson, M. G., Eidenschink, B. B., Iguchi, E., Zakharkin, S. O., LaRocca, C. J., Tolosa, E. J., Truty, M. J., Jacobsen, K., Fernandez-Zapico E., Davydova, J. (2021). Cancer imaging and therapy utilizing a novel NIS-expressing adenovirus: The role of adenovirus death protein deletion. Mol Ther Oncolytics(5;20), 659-668. PMID: 33816784 PMCID: PMC7985464 doi: 10.1016/j.omto.2021.03.002
  • Koodie, L., Robertson, M. G., Chandrashekar, M., Ruth, G., Dunning, M., Bianco, R. W., Davydova, J. (2019). Rodents Versus Pig Model for Assessing the Performance of Serotype Chimeric Ad5/3 Oncolytic Adenoviruses. Cancers, 11(2). PMID: 30744019 PMCID: PMC6406826 doi: 10.3390/cancers11020198
  • Shapovalova, M., Davydova, J., Henzler, C., Daniel, M., Dehm, S. M., Warlick, C. A., LeBeau, A. M. (2018). Exploiting the transcriptional specificity of the alpha-methylacyl-CoA racemase AMACR promoter for the molecular imaging of prostate cancer. Oncotarget, 9(94), 36693-36704. PMID: 30613352 PMCID: PMC6291171 doi: 10.18632/oncotarget.26401
  • Salzwedel, A. O., Han, J., LaRocca, C. J., Shanley, R., Yamamoto, M., Davydova, J. (2018). Combination of interferon-expressing oncolytic adenovirus with chemotherapy and radiation is highly synergistic in hamster model of pancreatic cancer. Oncotarget, 9(26), 18041-18052. PMID: 29719589 PMCID: PMC5915056 doi: 10.18632/oncotarget.24710
  • LaRocca, C. J., Davydova, J. (2016). Oncolytic Virotherapy Increases the Detection of Microscopic Metastatic Disease at Time of Staging Laparoscopy for Pancreatic Adenocarcinoma. EBioMedicine, 7, 15-6. PMID: 27322450 PMCID: PMC4909609 doi: 10.1016/j.ebiom.2016.05.019
  • Tasca, A., Stemig, M., Broege, A., Huang, B., Davydova, J., Zwijsen, A., Umans, L., Jensen, E. D., Gopalakrishnan, R., Mansky, K. C. (2015). Smad1/5 and Smad4 expression are important for osteoclast differentiation. Journal of cellular biochemistry, 116(7), 1350-60. PMID: 25711193 PMCID: PMC4431909 doi: 10.1002/jcb.25092
  • LaRocca, C. J., Han, J., Gavrikova, T., Armstrong, L., Oliveira, A. R., Shanley, R., Vickers, S. M., Yamamoto, M., Davydova, J. (2015). Oncolytic adenovirus expressing interferon alpha in a syngeneic Syrian hamster model for the treatment of pancreatic cancer. Surgery, 157(5), 888-98. PMID: 25731784 PMCID: PMC4417428 doi: 10.1016/j.surg.2015.01.006
  • Davydova, J., Yamamoto, M. (2013). Oncolytic adenoviruses: design, generation, and experimental procedures. Current protocols in human genetics, Chapter 12, Unit 12.14. PMID: 23853080  doi: 10.1002/0471142905.hg1214s78
  • Mansky, K. C., Jensen, E. D., Davydova, J., Yamamoto, M., Gopalakrishnan, R. (2013). Protein Kinase D Promotes In Vitro Osteoclast Differentiation and Fusion. J Biol Chem, 288(14), 9826-9834.  
  • Oneal, M. J., Trujillo, M. A., Davydova, J., McDonough, S., Yamamoto, M., Morris, 3rd, J. C. (2013). Effect of increased viral replication and infectivity enhancement on radioiodide uptake and oncolytic activity of adenovirus vectors expressing the sodium iodide symporter. Cancer gene therapy, 20(3), 195-200. PMID: 23412431  doi: 10.1038/cgt.2013.4
  • Miura, Y., Yamasaki, S., Davydova, J., Brown, E., Aoki, K., Vickers, S., Yamamoto, M. (2013). Infectivity-selective oncolytic adenovirus developed by high-throughput screening of adenovirus-formatted library. Molecular therapy : the journal of the American Society of Gene Therapy, 21(1), 139-48. PMID: 23032977 PMCID: PMC3538312 doi: 10.1038/mt.2012.205
  • Armstrong, L., Arrington, A., Han, J., Gavrikova, T., Brown, E., Yamamoto, M., Vickers, S. M., Davydova, J. (2012). Generation of a novel, cyclooxygenase-2-targeted, interferon-expressing, conditionally replicative adenovirus for pancreatic cancer therapy. American journal of surgery, 204(5), 741-50. PMID: 22748294 PMCID: PMC3467355 doi: 10.1016/j.amjsurg.2012.02.016
  • Oneal, M. J., Trujillo, M. A., Davydova, J., McDonough, S., Yamamoto, M., Morris, 3rd, J. C. (2012). Characterization of infectivity-enhanced conditionally replicating adenovectors for prostate cancer radiovirotherapy. Human gene therapy, 23(9), 951-9. PMID: 22694073 PMCID: PMC3440023 doi: 10.1089/hum.2012.047
  • Pham, L., Beyer, K., Jensen, E. D., Rodriguez, J. S., Davydova, J., Yamamoto, M., Petryk, A., Gopalakrishnan, R., Mansky, K. C. (2011). Bone morphogenetic protein 2 signaling in osteoclasts is negatively regulated by the BMP antagonist, twisted gastrulation. Journal of cellular biochemistry, 112(3), 793-803. PMID: 21328453 PMCID: PMC3335346 doi: 10.1002/jcb.23003
  • Davydova, J., Gavrikova, T., Brown, E. J., Luo, X., Curiel, D. T., Vickers, S. M., Yamamoto, M. (2010). In vivo bioimaging tracks conditionally replicative adenoviral replication and provides an early indication of viral antitumor efficacy. Cancer science, 101(2), 474-81. PMID: 19900190 PMCID: PMC4584507 doi: 10.1111/j.1349-7006.2009.01407.x
  • RamĂ­rez, P. J., Vickers, S. M., Ono, H. A., Davydova, J., Takayama, K., Thompson, T. C., Curiel, D. T., Bland, K. I., Yamamoto, M. (2008). Optimization of conditionally replicative adenovirus for pancreatic cancer and its evaluation in an orthotopic murine xenograft model. American journal of surgery, 195(4), 481-90. PMID: 18361926  doi: 10.1016/j.amjsurg.2007.04.014
  • Le, L. P., Le, H. N., Dmitriev, I. P., Davydova, J. G., Gavrikova, T., Yamamoto, S., Curiel, D. T., Yamamoto, M. (2006). Dynamic monitoring of oncolytic adenovirus in vivo by genetic capsid labeling. Journal of the National Cancer Institute, 98(3), 203-14. PMID: 16449680  doi: 10.1093/jnci/djj022
  • Davydova, J., Le, L. P., Gavrikova, T., Wang, M., Krasnykh, V., Yamamoto, M. (2004). Infectivity-enhanced cyclooxygenase-2-based conditionally replicative adenoviruses for esophageal adenocarcinoma treatment. Cancer research, 64(12), 4319-27. PMID: 15205347  doi: 10.1158/0008-5472.CAN-04-0064
  • Le, L. P., Everts, M., Dmitriev, I. P., Davydova, J. G., Yamamoto, M., Curiel, D. T. (2004). Fluorescently labeled adenovirus with pIX-EGFP for vector detection. Molecular imaging, 3(2), 105-16. PMID: 15296675  doi: 10.1162/1535350041464874
  • Yamamoto, M., Davydova, J., Wang, M., Siegal, G. P., Krasnykh, V., Vickers, S. M., Curiel, D. T. (2003). Infectivity enhanced, cyclooxygenase-2 promoter-based conditionally replicative adenovirus for pancreatic cancer. Gastroenterology, 125(4), 1203-1218.  doi: 10.1016/S0016-5085(03)01196-X
Selected Presentations

Selected Presentations

Chandrashekar, M., Koodie, L., Dunning, M., Ruth, G., Hajeri, P., Sato-Dahlman, M., Schappa-Faustich, J., Bianco, R., Davydova, J. "The porcine model for oncolytic adenovirus-based therapy", American Society of Gene and Cell Therapy. 21st Annual meeting, Chicago, Illinois, United States. May 16, 2018.
Koodie, L., Kawakami, E., Eidenschink, B., Sell, J., LaRocca, C., Jacobsen, K., Ryvlin, J., Tolosa, E., Morris, J. C., Fernandez-Zapico, M., Davydova, J. "Effect of Adenoviral Death Protein on Sodium Iodide Symporter (NIS)-Based Iodine Therapy and Imaging for Pancreatic Cancer", 20th Joint (IAP, JPS, AOPA) International Association of Pancreatology Meeting, Sendai, August 04, 2016.
Salzwedel, A., LaRocca, C., Huang, J., Davydova, J., Yamamoto, M. "Oncolytic Adenovirus Expressing IFN Alpha Works Synergistically with Chemoradiation", American Society for Gene and Cell Therapy (ASGCT). 18th Annual Meeting, Washington, D.C., United States. May 04, 2016.
Koodie, L., Kawakami, E., Eidenschink, B., Sell, J., LaRocca, C., Jacobsen, K., Ryvlin, J., Tolosa, E., Morris, J. C., Fernandez-Zapico, M., Davydova, J. "Effect of Adenoviral Death Protein on Sodium Iodide Symporter (NIS)-Based Iodine Therapy and Imaging for Pancreatic Cancer", American Society of Gene and Cell Therapy. 19th Annual meeting, Washington, D.C., May 03, 2016.
Sell, J., Oliveira, A., Jensen, E., Greeno, E., Yamamoto, M., Davydova, J. "Combination Cancer Treatment: Interferon-Expressing Adenovirus and 5FU Chemotherapy", Academic Surgical Congress (ASC). 11th Annual Meeting, Jacksonville, Florida, United States. February 02, 2016.
Salzwedel, A., LaRocca, C., Ryvlin, J., Han, J., Davydova, J., Yamamoto, M. "Oncolytic Adenovirus Expressing IFN-α Synergistically Potentiates Chemoradiation in PDAC Cells", IMV symposium, Wisconsin, Minnesota, United States. January 01, 2016.
Sell, J., Oliveira, A., Jensen, E., Greeno, E., Yamamoto, M., Davydova, J. "Combination Cancer Treatment: Interferon-Expressing Adenovirus and 5FU Chemotherapy", Masonic Cancer Center Symposium, University of Minnesota, Minneapolis, Minnesota, United States. November 10, 2015.
LaRocca, C., Oliveira, A., Han, J., Davydova, J., Alemany, R., Balague, C., Herzberg, M., Gopalakrishnan, R., Yamamoto, M. "Oncolytic adenovirus Targeted to the HPV E6 and E7 Oncoproteins as a Novel Treatment for Head &Neck Squamous Cell Carcinoma", The American Society of Gene and Cell Therapy 18th Annual Meeting, New Orleans, Louisiana, United States. May 13, 2015.
Eidenschink, B., Sell, J., Jacobsen, K., Trujillo, M., Morris, J., Yamamoto, M., Davydova, J. "Adenovirus Expansion of Radioiodine Therapy to Non-Thyroid Cancer Treatment and Diagnostics", The American Society of Gene and Cell Therapy 18th Annual Meeting, New Orleans, Louisiana, United States. May 13, 2015.
Sell, J., Oliveira, A., Yamamoto, M., Davydova, J. "Impact of 5FU and Radiation on the Replication of an Interferon-Expressing Adenovirus", Institute for Molecular Virology Symposium, University of Minnesota, Minneapolis, Minnesota, United States. May 11, 2015.
Sell, J., Oliveira, A., Yamamoto, M., Davydova, J. "Impact of 5FU and radiation on replication of interferon-expressing adenovirus", American Association for Cancer Research (AACR) 2015 Annual Meeting, Philadelphia, Pennsylvania, United States. April 18, 2015.
Eidenschink, B., Trujillo, M., Morris, J., Sato, M., Yamamoto, M., Davydova, J. "Oncolytic Adenovirus for Iodine Radiotherapy and Imaging of Pancreatic Cancer", The 45th Annual Meeting of American Pancreatic Association (APA), Big Island, Hawaii, United States. November 05, 2014.
LaRocca, C., Oliveira, A., Davydova, J., Herzberg, M., Gopalakrishnan, R., Yamamoto, M. "Multiple Injections of Oncolytic Adenoviruses Suppressed the Growth of Human Papilloma Virus (HPV)-Positive Head and Neck Squamous Cell Carcinomas in an In Vivo Model", Surgical Forum of the 2014 ACS Clinical Congress, Journal of the American College of Surgeons, San Francisco, California, United States. October 27, 2014.
Eidenschink, B., Sell, J., Jacobsen, K., Trujillo, M., Morris, J., Yamamoto, M., Davydova, J. "NIS-Adenovirus mediated Radioiodine Uptake in Pancreatic Cancer", The 5th Annual Masonic Cancer Center Research Symposium, Minneapolis, Minnesota, United States. October 20, 2014.
Sell, J., Oliveira, A., Shanley, R., Yamamoto, M., Davydova, J. "Impact of 5FU and Radiation on Replication of Interferon-Expressing Adenovirus", Masonic Cancer Center Symposium, University of Minnesota, Minneapolis, Minnesota, United States. October 20, 2014.
LaRocca, C., Emery, A., Han, J., Oliveira, A., Davydova, J., Herzberg, M. C., Gopalakrishnan, R., Yamamoto, M. "In Vivo Anti-tumor Effect of Oncolytic Adenoviruses Targeted to HPV-positive Head & Neck Squamous Cell Carcinomas", The Minnesota Surgical Society Fall Meeting, Rochester, Minnesota, United States. October 11, 2014.
Eidenschink, B., Sell, J., Jacobsen, K., Trujillo, M., Morris, J., Yamamoto, M., Davydova, J. "New Pancreatic Cancer Therapy and Diagnostics: NIS-Adenoviral vector Radioactive Uptake", The 3rd Annual CTSI Poster Session, Minneapolis, Minnesota, United States. September 15, 2014.
Oliveira, A., LaRocca, C., Han, J., Shanley, R., Davydova, J., Yamamoto, M. "Oncolytic Adenovirus as a Potential Tool for Pancreatic Cancer Combination Therapy", Japan Society of Gene Therapy (JSGT) 2014 20th Annual Meeting, Tokyo, Japan. August 06, 2014.
LaRocca, C., Emery, A., Han, J., Oliveira, A., Davydova, J., Herzberg, M. C., Gopalakrishnan, R., Yamamoto, M. "Conditionally Replicative Oncolytic Adenoviruses as a Novel Treatment for HPV-Positive head and Neck Squamous Cell Carcinomas", Japan Society of Gene Therapy (JSGT) 2014 20th Annual Meeting, Tokyo, Japan. August 06, 2014.
LaRocca, C., Oliveira, A., Davydova, J., Yamamoto, M. "Oncolytic Adenovirus Expressing IFN Sensitizes Pancreatic Cancer to Chemoradiotherapy", The American Society of Gene and Cell therapy meeting(ASGCT) 17th Annual Meeting, Washington, D.C., United States. May 21, 2014.
LaRocca, C., Oliveira, A., Davydova, J., Yamamoto, M. "Esopageal Cancer Treatment Using an INF-Expressing Oncolytic Adenovirus in Combination with Chemotherapy and radiation", The American Society of Gene and Cell therapy meeting(ASGCT) 17th Annual Meeting, Washington, D.C., United States. May 21, 2014.
Eidenschink, B., Trujillo, M., Oneal, M., Morris, J., Yamamoto, M., Davydova, J. "Systemic treatment with Fiber-redesigned Oncolytic Adenovirus Eliminates tumors in Pancreatic Cancer In Vivo Models", The American Society of Gene and Cell therapy meeting (ASGCT) 17th Annual Meeting, Washington, D.C., United States. May 21, 2014.
Eidenschink, B., Trujillo, M., Oneal, M., Morris, J., Yamamoto, M., Davydova, J. "NIS-mediated Radioiodine Therapy and Imaging for Pancreatic Cancer with Oncolytic Adenovirus", The American Society of Gene and Cell therapy meeting (ASGCT) 17th Annual Meeting, Washington, D.C., United States. May 21, 2014.
Oliveira, A., LaRocca, C., Han, J., Shanley, R., Yamamoto, M., Davydova, J. "Oncolytic Adenovirus Expressing IFN Sensitizes Pancreatic Cancer to Chemoradiotherapy.", he American Society of Gene and Cell therapy meeting (ASGCT) 17th Annual Meeting, Washington, D.C., United States. May 21, 2014.
Sato, M., Miura, Y., Davydova, J., Yamamoto, M. "The isolation of CD133-Targeted Adenovirus by Screening with a Fiver-Modified Adenovirus Library", The American Society of Gene and Cell therapy meeting (ASGCT) 17th Annual Meeting, Washington, D.C., United States. May 21, 2014.
LaRocca, C., Oliveira, A., Davydova, J., Yamamoto, M. "Interferon Expressing Oncolytic Adenovirus for Esophageal Cancer", Digestive Diseases Week, Chicago, Illinois, United States. May 05, 2014.
LaRocca, C., Oliveira, A., Davydova, J., Yamamoto, M. "Interferon-Expressing Oncolytic Adenovirus-based Chemoradiotherapy for Esophageal Cancer", Minnesota Surgical Society Spring Meeting, Minneapolis, Minnesota, United States. April 14, 2014.
LaRocca, C., Emery, A., Han, J., Davydova, J., Herzberg, M. C., Gopalakrishnan, R., Yamamoto, M. "Oncolytic Adenoviruses Targeting HPV Positive Head & Neck Squamous Cell Carcinomas", Society of Surgical Oncology Cancer Symposium, Phoenix, Arizona, United States. March 12, 2014.
Han, J., Miura, Y., Shanley, R., Luo, X., Aoki, K., Greeno, E., Vickers, S., Yamamoto, M., Davydova, J. "Adenovirus-Delivered Interferon Sensitized Chemo- and Radiotherapy for Pancreatic Cancer", The Annual Meeting of American Pancreatic Association (APA)., Miami, Florida, United States. October 30, 2013.
Davydova, J., Trujillo, M., Oneal, M., Miura, Y., Han, J., Morris, J., Yamamoto, M. "NIS-Mediated Radioiodine Therapy and Imaging for Pancreatic Cancer", The Annual Meeting of American Pancreatic Association (APA), Miami, Florida, United States. October 30, 2013.
Miura, Y., Davydova, J., Han, J., Yamamoto, M. "Successful Systemic Cancer Targeting by Adenovirus Vector with AB-Loop Redesigned Fiber Via Reducing Liver Sequestration", apanese Society of Gene Therapy (JSGT) 2013 19th Annual Meeting, Okayama, Japan. July 04, 2013.
Han, J., Miura, Y., Shanley, R., Luo, X., Aoki, K., Vickers, S., Yamamoto, M., Davydova, J. "Interferon Expressing Oncolytic Adenovirus Sensitized Chemotherapy and radiation for Pancreatic cancer in Vitro and in Vivo Models", Japanese Society of Gene Therapy (JSGT) 2013 19th Annual Meeting, Okayama, Japan. July 04, 2013.
Miura, Y., Davydova, J., Han, J., Yamamoto, M. "Systemic Administration of Fiber-Redesigned Infectivity-selective Oncolytic Adenovirus for Cancer Treatment", Japan Society of Gene Therapy (JSGT) 2013 19th Annual Meeting, Okayama, Japan. July 04, 2013.
Miura, Y., Davydova, J., Han, J., Yamamoto, M. "Systemic Administration of Fiber-Redesigned Infectivity-selective Oncolytic Adenovirus for Cancer Treatment", The 7th Oncolytic Viruses Meeting, Quebec City, QC, Canada. June 15, 2013.
Davydova, J., Trujillo, M., Oneal, M., McDonough, S., Miura, Y., Han, J., Morris, J., Yamamoto, M. "Oncolytic Adenovirus for Iodine Radiotherapy and Imaging of Pancreatic Cancer", 2013 Department of Surgery Research Day, University of Minnesota, Minneapolis, Minnesota, United States. June 10, 2013.
Han, J., Miura, Y., Shanley, R., Luo, X., Aoki, K., Vickers, S., Yamamoto, M., Davydova, J. "Oncolytic Adenovirus-Mediated Interferon Expression Augments Chemoradiation Therapy in Immunocompetent Pancreatic Cancer Model", 2013 Department of Surgery Research Day, University of Minnesota, Minneapolis, Minnesota, United States. June 10, 2013.
Han, J., Armstrong, L., Miura, Y., Shanley, R., Luo, X., Jensen, E., Greeno, E., Vickers, S., Yamamoto, M., Davydova, J. "Adenovirus-Mediated Interferon Therapy Sensitized Chemotherapy and Radiation for Pancreatic Cancer in Vitro and in Vivo Models", The 54th Annual Julia Davydova, MD, PhD, Updated 12/21/201722Digestive Disease Week (DDW) Meeting at the Orange County Convention Center, Orlando, Florida, United States. May 18, 2013.
Miura, Y., Davydova, J., Han, J., Yamamoto, M. "Successful Systemic Cancer Targeting by Adenovirus Vector with AB-Loop Redesigned Fiber Via Reducing Liver Sequestration", The American Society of Gene and Cell therapy meeting (ASGCT) 16th Annual Meeting, Salt Lake City, Utah, United States. May 15, 2013.
Miura, Y., Davydova, J., Han, J., Yamamoto, M. "Systemic Administration of Fiber-Redesigned Infectivity-selective Oncolytic Adenovirus for Cancer Treatment", The American Society of Gene and Cell therapy meeting (ASGCT) 16th Annual Meeting, Salt Lake City, Utah, United States. May 15, 2013.
Han, J., Miura, Y., Shanley, R., Luo, X., Aoki, K., Vickers, S., Yamamoto, M., Davydova, J. "Oncolytic Adenovirus-Mediated Interferon Expression Augments Chemoradiation Therapy in Immunocompetent Pancreatic Cancer Model", The American Society of Gene and Cell therapy meeting (ASGCT) 16th Annual Meeting, Salt Lake City, Utah, United States. May 15, 2013.
Miura, Y., Davydova, J., Yamamoto, M. "Infectivity selective oncolytic adenovirus for pancreatic cancer by redesigning the AB-loop via adenovirus library screening", The Annual Meeting of American Pancreatic Association (APA) and the International Association of Pancreatology (IAP), Miami, Florida, United States. October 31, 2012.
Davydova, J., Trujillo, M., Oneal, M., McDonough, S., Han, J., Vickers, S., Morris, J., Yamamoto, M. "Oncolytic adenovirus for imaging and treatment of pancreatic cancer", The Annual Meeting of American Pancreatic Association (APA) and the International Association of Pancreatology (IAP), Miami, Florida, United States. October 31, 2012.
Han, J., Miura, Y., Shanley, R., Luo, X., Aoki, K., Vickers, S., Yamamoto, M., Davydova, J. "Improved effect of chemoradiotherapy in combination with adenoirus-medicated interferon therapy in an immunocompetent model", The Annual Meeting of American Pancreatic Association (APA) and the International Association of Pancreatology (IAP), Miami, Florida, United States. October 31, 2012.
Han, J., Miura, Y., Shanley, R., Luo, X., Aoki, K., Vickers, S., Yamamoto, M., Davydova, J. "Improved Effect of Chemoradiotherapy in Combination with Adenovirus-Mediated Interferon Therapy", International Symposium on Pancreas Cancer 2012, Kyoto, Japan. October 04, 2012.
Han, J., Trujillo, M., Oneal, M., McDonough, S., Vickers, S., Morris, J., Davydova, J. "Novel Theranostic for Imaging and Treatment of Pancreatic Cancer", International Symposium on Pancreas Cancer 2012, Kyoto, Japan. October 04, 2012.
Miura, Y., Yamasaki, S., Davydova, J., Yamamoto, M. "Infectivity-selective oncolytic adenovirus developed by screening of high diversity targeting ligand library in the format of adenovirus capsid", Japanese Society of Gene Therapy (JSGT) 18th Annual Meeting, Kumamoto, Japan. July 28, 2012.
Yamasaki, S., Miura, Y., Davydova, J., Vickers, S., Yamamoto, M. "Intravenous human Adenovirus 40 vaccine inhibits growth and metastasis for pancreatic cancer", Japanese Society of Gene Therapy (JSGT) 18th Annual Meeting, Kumamoto, Japan. July 28, 2012.
Yamasaki, S., Miura, Y., Davydova, J., Vickers, S., Yamamoto, M. " A single oral administration of human adenovirus 40 vaccine against allergy and anaphylaxis", Japanese Society of Gene Therapy (JSGT) 18th Annual Meeting, Kumamoto, Japan. July 28, 2012.
Han, J., Nelson, S., Dos Santos, T., Shanley, R., Luo, X., Aoki, K., Vickers, S., Yamamoto, M., Davydova, J. "Antitumor Effect of Oncolytic Adenovirus-Based Interferon Therapy in Combination with Chemoradiotherapy in an Immunocompetent Hamster Model", Japanese Society of Gene Therapy (JSGT) 18th Annual Meeting, Kumamoto, Japan. July 28, 2012.
Davydova, J., Trujillo, M., Oneal, M., McDonough, S., Nelson, S., Han, J., Vickers, S., Morris, J., Yamamoto, M. "Oncolytic Adenovirus Expressing a Dual-Function Gene for Imaging and Treatment of Pancreatic Cancer", Digestive Disease Week (DDW) Meeting, San Diego, California, United States. May 19, 2012.
Miura, Y., Davydova, J., Yamamoto, M. "Transductionally-Retargeted Infectivity Selected Oncolytic Adenovirus with Redesigned AB-Loop Targeting Cell Surface Mesothelin", American Society of Gene and Cell therapy meeting (ASGCT), Philadelphia, Pennsylvania, United States. May 16, 2012.
Yamasaki, S., Miura, Y., Davydova, J., Vickers, S., Yamamoto, M. "A Single Oral Administration of Human Adenovirus 40 Vaccine Against Allergy and Anaphylaxis", American Society of Gene and Cell therapy meeting (ASGCT), Philadelphia, Pennsylvania, United States. May 16, 2012.
Han, J., Nelson, S., Armstrong, L., Dos Santos, T., Shanley, R., Luo, X., Aoki, K., Vickers, S., Yamamoto, M., Davydova, J. "Improved Antitumor Effect of Adenovirus-Mediated Interferon Therapy in Combination with Chemoradiotherapy in a Syngeneic Immunocompetent Hamster Model", American Society of Gene and Cell therapy meeting (ASGCT), Philadelphia, Pennsylvania, United States. May 16, 2012.
Han, J., Armstrong, L., Brown, E., Aoki, K., Vickers, S., Yamamoto, M., Davydova, J. "Improved Effect of Chemoradiotherapy in Combination with Oncolytic Adenovirus Expressing Interferon-α for Pancreatic Cancer", The 42nd Annual Meeting of American Pancreatic Association (APA), Chicago, Illinois, United States. November 02, 2011.
Davydova, J., Trujillo, M., McDonough, S., Oneal, M., Brown, E., Han, J., Vickers, S., Morris, J., Yamamoto, M. "Oncolytic Adenovirus expressing a Dual-Function gene for Imaging and Treatment of Pancreatic Cancer", Japanese Society of Gene Therapy (JSGT) 17th Annual Meeting, Fukuoka, Japan. July 15, 2011.
Davydova, J., Armstrong, L., Han, J., Brown, E., Aoki, K., Vickers, S., Yamamoto, M. "Adenovirus-Mediated Interferon-α Gene Therapy for Pancreatic Cancer", Japanese Society of Gene Therapy (JSGT) 17th Annual Meeting, Fukuoka, July 15, 2011.
Han, J., Armstrong, L., Brown, E., Aoki, K., Vickers, S., Yamamoto, M., Davydova, J. "Chemotherapy Sensitization of Pancreatic cancer with Oncolytic Adenovirus expressing Interferon-α", Japanese Society of Gene Therapy (JSGT) 17th Annual Meeting, Fukuoka, July 15, 2011.
Han, J., Armstrong, L., Brown, E., Aoki, K., Vickers, S., Yamamoto, M., Davydova, J. "A Novel Gene Therapy in Combination with Chemotherapeutic to Treat Pancreatic Cancer", Department of Surgery Research Day, University of Minnesota, Minneapolis, Minnesota, United States. June 13, 2011.
Davydova, J., Armstrong, L., Brown, E., Han, J., Vickers, S., Yamamoto, M. "Adenoviral-Mediated Interferon-α Gene Therapy for Pancreatic Cancer", American Society of Gene and Cell Therapy (ASGCT) 14th Annual Meeting, Seattle, Washington, United States. May 18, 2011.
Armstrong, L., Davydova, J., Brown, E., Yamamoto, M., Vickers, S. "Generation of a Novel, Cox2-Targeted, Interferon-Expressing, Conditionally-Replicative Adenovirus for Pancreatic Cancer Therapy", 21st Annual Scientific Assembly of the Society of Black Academic Surgeons, Boston, Massachusetts, United States. April 28, 2011.
Han, J., Armstrong, L., Brown, E., Aoki, K., Vickers, S., Yamamoto, M., Davydova, J. "A Novel Gene Therapy in Combination with Chemotherapeutic to Treat Pancreatic Cancer", “Accelerating the Future: The Changing Face of Health in America” Symposium, Minneapolis, Minnesota, United States. April 19, 2011.
Han, J., Armstrong, L., Brown, E., Aoki, K., Vickers, S., Yamamoto, M., Davydova, J. "A Novel Gene Therapy in Combination with Chemotherapeutic to Treat Pancreatic Cancer", The 76thAnnual Meeting & 23rd Winchell Undergraduate Symposium, Brooklyn Park, Minnesota, United States. April 16, 2011.
Han, J., Armstrong, L., Brown, E., Aoki, K., Vickers, S., Yamamoto, M., Davydova, J. "A Novel Gene Therapy in Combination with Chemotherapeutic to Treat Pancreatic Cancer", University of Minnesota Undergraduate Research Symposium, University of Minnesota, Minneapolis, Minnesota, United States. April 13, 2011.
Armstrong, L., Davydova, J., Brown, E., Han, J., Yamamoto, M., Vickers, S. "Delivery of Interferon Alpha Using a Novel Cox2-Controlled Adenovirus for Pancreatic Cancer Therapy", The 6th Annual Academic Surgical Congress, Huntington Beach, California, United States. February 01, 2011.
Davydova, J., Trujillo, M., McDonough, S., Oneal, M., Brown, E., Han, J., Armstrong, L., Vickers, S., Morris, J., Yamamoto, M. "NIS-CRAD as a Novel Theranostic for Pancreatic Cancer", American pancreatic Association (APA), Chicago, Illinois, United States. November 03, 2010.
Davydova, J., Brown, E., Vickers, S., Yamamoto, M. "Infectivity-Enhanced Oncolytic Adenoviral Vectors Expressing Syngeneic IFN-alpha for Pancreatic Cancer", Japanese Society of Gene Therapy, 15th Annual Meeting, Japan. June 01, 2009.
Arrington, A., Davydova, J., Vickers, S., Yamamoto, M. "Anti-ERBB2 si- and sh-RNAs Suppress Cell Growth in ERRB2-Overexpressing Upper Gastrointestinal Adenocarcinomas", DDW, Chicago, Illinois, United States. May 30, 2009.
Arrington, A., Davydova, J., Brown, E., Humar, A., Jensen, E., Vickers, S., Yamamoto, M. "Human Tissue Slice Model for evaluating Conditionally Replicative Oncolytic Adenovirus Specificity to Pancreatic Cancer", DDW, Chicago, Illinois, United States. May 30, 2009.
Davydova, J., Brown, E., Vickers, S., Yamamoto, M. "Infectivity-Enhanced Oncolytic Adenoviral Vectors Expressing Syngeneic IFN-alpha for Pancreatic Cancer", ASGT 12th Annual Meeting, San Diego, California, United States. May 27, 2009.
Arrington, A., Dahlberg, P., Davydova, J., Vickers, S., Yamamoto, M. "ERBB2 suppression decreases cell growth via apoptosis in gastrointestinal adenocarcinomas", Academic Surgical Congress, Sanibel, Florida, United States. February 03, 2009.
Arrington, A., Dahlberg, P., Davydova, J., Vickers, S., Yamamoto, M. "siRNA based ERBB2 suppression decreases cell growth in ERBB2-overexpressing gastrointestinal adenocarcinomas", Minnesota Surgical Society Fall Conference, Alexandria, Minnesota, United States. October 25, 2008.
Arrington, A., Dahlberg, P., Davydova, J., Vickers, S., Yamamoto, M. "siRNA based ERBB2 suppression decreases cell growth in ERBB2-overexpressing gastrointestinal adenocarcinomas", Association of Women Surgeons, San Francisco, California, United States. October 12, 2008.
Davydova, J., Brown, E., Yamasaki, S., Miura, Y., Arlington, A., Vickers, S., Yamamoto, M. "Development of the Models for Assessing the Behavior of Tropism-Modified Replication Competent Human Adenoviruses", Japanese Society of Gene Therapy, 14th Annual Meeting, Sapporo, Hokkaido, June 12, 2008.
Davydova, J., Brown, E., Vickers, S., Yamamoto, M. "Porcine as an in vivo model to assess toxicity of tropism-modified replication competent adenoviruses", American Society of Gene and Cell Therapy. 11th Annual meeting, Boston, Massachusetts, United States. May 28, 2008.
Davydova, J., Brown, E., Vickers, S., Yamamoto, M. "New Model for Testing Safety of Oncolytic Fiber-Modified Conditionally Replicative Adenovirus Designed for Pancreatic Cancer", Digestive Disease Week, San Diego, California, United States. May 17, 2008.
Davydova, J., Brown, E., Yamamoto, M. "Conditionally-replicative Adenoviral Vectors with Bioluminescence-based Replication Monitoring Capability for Lung Cancer", Japanese Society of Gene Therapy (JSGT) 13th Annual Meeting, Nagoya, Japan. June 28, 2007.
Davydova, J., Brown, E., Yamamoto, M. "Conditionally-replicative Adenovaral Vectors with Bioluminescence-based Replication Monitoring Capability for Lung Cancer", American Society of Gene Therapy, 10th Annual Meeting, Seattle, Washington, United States. May 30, 2007.
Nelson, A., Davydova, J., Gavrikova, T., Yamamoto, M. "Gemcitabine significantly potentiates the anti-tumor effect of conditionally replicative adenovirus in pancreatic cancer model", Digestive Disease Week, Washington, D.C., United States. May 19, 2007.
Davydova, J., Nelson, A., Gavrikova, T., Ono, H., Yamamoto, M. "Promoter-controlled Conditionally-replicative Adenoviruses with Imaging capability for lung cancer", American Association of Cancer Research, Los Angeles, California, United States. April 14, 2007.
Davydova, J., Yamamoto, M. "Promoter-controlled Conditionally-Replicative Adenoviruses with Imaging Capability for Lung Cancer", Oncolytic Viruses as Cancer Therapeutics, The 4th International Conference, Carefree Resort, Arizona, United States. March 14, 2007.
Davydova, J., Ono, H., Le, L., Yamamoto, M. "Non-invasive in vivo Monitoring of Adenovirus Replication and its Application for Tumor Detection", The Japan Society of Gene Therapy, 12th Annual Meeting, Tokyo, Japan. August 21, 2006.
Davydova, J., Nelson, A., Gavrikova, T., Le, L., Ono, H., Curiel, D., Yamamoto, M. "Monitoring of Promoter-controlled Adenoviral Replication with Noninvasive Imaging in Lung Cancer", American Society of Gene Therapy 9th Annual Meeting, Baltimore, Maryland, United States. May 31, 2006.
Davydova, J., Gavrikova, T., Yamamoto, S., Nelson, A., Yamamoto, M. "Non-invasive in vivo Visualization of Pancreatic Cancer Signature with Conditionally Replicative Adenovirus System", Digestive Disease Week, Los Angeles, California, United States. May 20, 2006.
Ramirez, P., Davydova, J., Vickers, S., Curiel, D., Yamamoto, M. "Fiber Modification Augments Antitumor Effect of Conditionally Replicative Adenovirus upon Systemic Administration in Orthotopic Pancreatic Cancer Model", American Society of Cancer Research (AACR), Washington, D.C., United States. April 01, 2006.
Davydova, J., Ono, H., Le, L., Yamamoto, M. "Non-invasive in vivo Visualization of Adenovirus Replication and its Application for Monitoring and Tumor Detection", Cold Spring Harbor Meeting: “Target Definition & Vector design for Molecular Medicine”, New York, United States. November 10, 2005.
Davydova, J., Ono, H., Le, L., Gavrikova, T., Yamamoto, S., Nelson, A., Curiel, D., Yamamoto, M. "Noninvasive Optical Monitoring of Conditionally Replivative Adenovirus Replication", American Society of Gene Therapy 8th Annual Meeting, St. Louis, Missouri, United States. June 01, 2005.
Ramirez, P., Davydova, J., Vickers, S., Curiel, D., Yamamoto, M. "Intravenous Administration of Infectivity Enhanced Conditionally Replicative Adenovirus Shows Augmented Antitumor Effect in Orthotopic Pancreatic Cancer Model", Digestive Disease Week, Chicago, Illinois, United States. May 01, 2005.
Ono, H., Le, L., Davydova, J., Gavrikova, T., Ramirez, P., Curiel, D., Yamamoto, M. "Non-invasive in vivo Visualization of Adenovirus Replication with Fluorescent Protein Gene Placed in E3 Region", American Association of Cancer Research, Anaheim, California, United States. April 16, 2005.
Ramirez, P., Ono, H., Davydova, J., Curiel, D., Vickers, S., Yamamoto, M. "Systemic administration of conditionally replicative adenoviruses in an orthotopic nude mouse pancreatic cancer model", Alabama Chapter of American College of Surgeons, Point Clear, Alabama, United States. June 12, 2004.
Gavrikova, T., Davydova, J., Le, L., Ono, H., Ramirez, P., Krasnykh, V., Curiel, D., Yamamoto, M. "New Generation Conditionally Replicative Adenovirus for Hormone-Refractory Prostate Cancer", American Society of Gene Therapy 7th Annual Meeting, Minneapolis, Minnesota, United States. June 02, 2004.
Contact

Contact

Address

Division of Basic & Translational Research, Department of Surgery, University of Minnesota
420 Delaware St. SE - MMC 195
Minneapolis, MN 55455

Administrative Contact

Kelli Tourand |  612-624-4581 | toura018@umn.edu