Denis Clohisy, MD

Professor and Chair, Department of Orthopedic Surgery

Denis Clohisy

Contact Info

Office Phone 612-672-7100

Fax 612-273-7959

Office Address:
M Health Clinics and Surgery Center
909 Fulton St SE
4th Floor
Minneapolis, MN 55455

Mailing Address:
University of Minnesota
Department of Orthopedic Surgery
2450 Riverside Avenue South
Suite R200
Minneapolis, MN 55454

Administrative Assistant Name
Connie Butterfuss

Administrative Phone

Administrative Email

Administrative Fax Number

Additional Locations


  • Orthopedic Clinic

Professor and Chair, Department of Orthopedic Surgery

Professor, Department of Orthopedic Surgery

Orthopedic Surgeon

Medical School, Northwestern University Medical School, IL

Orthopaedic Surgery Residency, University of Minnesota, MN

Pathology Fellowship, Washington University,School of Medicine, MO

Pathology Fellowship, Massachusetts General Hospital, MA

Musculoskeletal Oncology Fellowship, Harvard Medical School, MA

My passion is bringing cutting-edge techniques, compassion, and hope to orthopedic oncology patients and their families. I listen to my patient’s needs and work with them to create a care plan tailored to their unique situation. I enjoy getting to know my patients and improving their quality of life.


Dr. Clohisy is a professor and chair of the Department of Orthopedic Surgery at the University of Minnesota and a member of the University of Minnesota Cancer Center. He specializes in musculoskeletal oncology with a focus on both primary and metastatic cancers of bone and the management of musculoskeletal problems in hemophilia. His clinical research focuses on the effect of surgical treatment of skeletal metastasis on health status, and he has also researched the cellular mechanisms of tumor osteolysis and mechanisms of bone cancer pain. He is committed to advancing all levels of musculoskeletal education and has interest and experience in developing both outstanding community orthopedic surgeons and orthopedic clinician scientists. His research program has had NIH funding for 23 consecutive years and he currently leads an Academic Health Center NIH training grant for graduate and past doctoral students.


  • Orthopedics
  • Cancer

Awards & Recognition

  • Best Doctors in America®: 2007-2010, 2011-2012, 2013
  • Mpls.St. Paul Magazine "Top Doctors:" 2009-2010, 2012-2015, 2020
  • U.S. News & World Report Top Doctor: 2012
  • Minnesota Monthly "Top Doctors:" 2014, 2018, 2020

Professional Associations

  • Chair of the Department of Orthopedic Surgery
  • Elected member of the University of Minnesota Physicians (UMP) Board of Directors, serves on the UMP Executive committee and Chairs the UMP Clinical Strategies Committee
  • Member, American Board of Orthopaedic Surgery Board Exam Committee
  • Member, American Orthopaedic Association Critical Issues Committee
  • Member, American Academy of Orthopaedic Surgeons Communicative Cabinet and Council on Education.


Research Summary/Interests

  • Bone and Soft Tissue Neoplasms
  • Osteolysis
  • Osteoclasts
  • Mouse Genetic Engineering
  • Bone Cancer Pain
  • Experimental Sarcoma Models


  • Publications on PubMed
  • Clohisy DR, Yaszemski MJ, Lipman J. “Leadership, Communication, and Negotiation Across a Diverse Workforce.” An AOA Critical Issues Symposium. J Bone Joint Surg Am 2017 Jun 21;99A(12):1065.
  • Takahashi, T, MacCormick L, Ellermann J, Clohisy D, Marrette S. “Giant cell tumor within the proximal tibia after ACL reconstruction”. Case Rep Radiology. Volume 2016.
  • Jones DA, Shideman C, Yuan J, Dusenbery K, Manivel CJ, Clohisy DR, Cheng EY, Shanley R, Cho CL. “Management of unplanned excision for soft-tissue sarcoma with preoperative radiotherapy followed by definitive resection”. Am J Clin Oncol May 29 (Epub ahead of print), 2016.



  • Musculoskeletal oncology with focus on both primary and metastatic cancers of the bone
  • Management of musculoskeletal problems in hemophilia

Board Certifications

American Board of Orthopaedic Surgery

Clinical Interests

Musculoskeletal oncology with focus on both primary and metastatic cancers of the bone; Management of musculoskeletal problems in hemophilia

Hospital Privileges

University of Minnesota Masonic Children's Hospital; University of Minnesota Medical Center