Kadambari Chandra Shekar

Ph.D. Candidate,

Kadambari Chandra Shekar

Contact Info

Ph.D. Candidate


Ph.D., Physiology, University of Minnesota, Department of Integrative Biology and Physiology, exp Nov. 2019

M.S., Molecular Medicine, University of Maryland at Baltimore, 2012

BTech, Biotechnology, Sri Venkateswara College of Engineering, India, 2010


Kadambari is a Study Director at Wuxi Apptec, a contract research organization in St.Paul, Minnesota.

Summary

Dissertation Title: Poloxamer 188 in pre-clinical models of acute myocardial infarction- old problem, new perspectives

Advisor: Demetris Yannopoulos, M.D.

Date of Final Defense: October 25, 2019

Awards & Recognition

Dr. Marvin and Hadassah Bacaner award in Physiology, University of Minnesota (Apr 2019)

ReSS AHA young investigator award for best abstract, American Heart Association Scientific sessions, New Orleans, LA (Nov 2016)

Research

Publications

1. ShekarKC, Sebastian P, Ripeckyj A, Olocco M, Kosmopoulos M, McKnite SH, Matsuura TR, Bartos JA, Metzger JM and Yannopoulos D; “Poloxamer 188 treatment benefit on the myocardium does not extend to the cardiac mitochondrial subpopulations in a porcine model of acute myocardial infarction”; (Submission in progress to J Mol Cell Cardiol, Oct 2019)

2. ShekarKC, BartosJA, Ripeckyj A, Sebastian P, MatsuuraTR, MetzgerJM and Yannopoulos D; “Membrane stabilizing copolymer poloxamer 188 increases survival despite minimal changes in infarct size in a porcine model of ST-elevation myocardial infarction”;(Manuscript in preparation for submission to JACC Basic Transl Sci.)

3. Ribeiro Jr RF, Dabkowski ER, Shekar KC, O’Connell KA, Hecker PA, Murphy MP; “MitoQ improves mitochondrial dysfunction in heart failure induced by pressure overload; (Free Radic Biol Med.2018 Mar; PMID:29421236)

4. Bartos JA, Voicu S, Matsuura TR, Tsangaris A, Sideris G, Oestreich BA, George SA, Olson M, Shekar KC, Rees JN, Carlson K, Sebastian P, McKnite SH, Raveendran G, Aufderheide TP, Yannopoulos D; “Role of epinephrine and extracorporeal membrane oxygenation in the management of ischemic refractory ventricular fibrillation: a randomized trial in pigs”;(JACC Basic Transl Sci.2017 Jun; PMID:29152600)

5. Matsuura TR, Bartos JA, Tsangaris A, Shekar KC, Olson MD, Riess ML, Bienengraeber M, Aufderheide TP, Neumar RW, Rees JN, McKnite SH, Dikalova AE, Dikalov SI, Douglas HF, Yannopoulos D; “Early effects of prolonged cardiac arrest and ischemic postconditioning during cardiopulmonary resuscitation on cardiac and brain mitochondrial function in pigs”; (Resuscitation 2017 Jul 116; PMID: 28408349)

6. Bartos JA, Matsuura TR, Tsangaris A, Olson M, McKnite SH, Rees JN, Haman K, Shekar KC, Riess ML, Bates FS, Metzger JM, Yannopoulos D; “Intracoronary poloxamer 188 prevents reperfusion injury in a porcine model of ST-segment elevation myocardial infarction” (JACC Basic Transl Sci.Jun 1, 2015; PMID:27695713)

7. Adhikari N, Shekar KC, Staggs R, Win Z, Steucke K, Lin YW, Wei LN, Alford P, Hall JL; “Guidelines for the isolation and characterization of murine vascular smooth muscle cells”;(Intl Society of Cardiovascular Translational Research, Apr 2015, PMID: 25788147)

8. Shekar KC, Li L, Dabkowski ER, Xu W, Ribeiro RF Jr, Hecker PA, Recchia FA, Sadygov RG, Willard B, Kasumov T, Stanley WC; “Cardiac mitochondrial proteome dynamics with heavy water reveals stable rate of mitochondrial protein synthesis in heart failure despite decline in mitochondrial oxidative capacity” (J Mol Cell Cardiol, Jul 1 2014, PMID: 24995939)