Megan Beetch, PhD

Post Doctoral Fellow, Department of Integrative Biology and Physiology (IBP)

Postdoctoral Fellow, University of Minnesota, Integrative Biology and Physiology, 2020 - present

PhD, Human Nutrition Program, University of British Columbia, 2020

BS, Biology, University of St Thomas, 2015

Summary

Research

Research Summary/Interests

Fetal programming of obesity and insulin resistance; murine models of placental insufficiency via genetic manipulation of nutrient sensor proteins (mTOR) and anabolic signaling (IGF1R) in the placenta; investigation of placental nutrient transport and fetal growth restriction in murine models; molecular dissection of offspring islets and peripheral tissues to understand programming and health trajectory.

Research Funding Grants

  • Minnesota Obesity Prevention Training Program (T32) National Institute of Health, NIDDK, UMN (10/2022-)
  • Training Program in Diabetes, Endocrinology and Metabolism (2nd year; NIH 5T32DK007203-42) National Institute of Health, NIDDK, University of Minnesota (Funded 10/2021 - present)
  • NIH F32 Postdoctoral Fellowship (A0 submission)
    National Institute of Health, NICHD (submitted 4/4022)
  • NIH F32 Postdoctoral Fellowship (A1 resubmission)
    National Institute of Health, NIDDK (submitted 4/4021)
  • Training Program in Diabetes, Endocrinology and Metabolism (1st year; NIH 5T32DK007203-41) National Institute of Health, NIDDK, University of Minnesota (Funded 10/2020-9/2021)
  • NIH F32 Postdoctoral Fellowship (A0 submission)
    National Institute of Health, NIDDK (submitted 8/2020)

Publications

  • Chung G, Mohan R, Beetch M, Jo S, Alejandro EU. Placental insulin receptor transiently regulates glucose homeostasis in the adult mouse offspring of multiparous dams. Biomedicines. 2022 Mar 1;10(3):575. PMCID: PMC8945682
  • Moore M, Avula N, Wong A, Beetch M, Jo S, Alejandro EU. Reduction in O-GlcNAcylation mitigates the severity of inflammatory response in cerulein-induced acute pancreatitis in a mouse model. Biology. 2022 Feb 22;11(3):347. PMCID: PMC8945657
  • Akhaphong B, Baumann DC, Beetch M, Lockridge AD, Jo S, Wong A, Zemanovic T, Mohan R, Fondevilla DL, Sia M, Pineda-Cortel MRB, Alejandro EU. Placental mTOR complex 1 regulates fetal programming of obesity and insulin resistance in mice. JCI Insight. 2021 Jul 8. doi: 10.1172/jci.insight.149271.
  • Moore M, Avula N, Jo S, Beetch M, Alejandro EU. Disruption of O-linked N-acetylglucosamine signaling in placenta induces insulin sensitivity in female offspring. Int J Mol Sci. 2021 Jun 28;22(13):6918. PMCID: PMC8267851
  • Essawy A, Jo S, Beetch M, Lockridge A, Gustafson E, Alejandro EU. O-linked N-acetylglucosamine transferase (OGT) regulates pancreatic a-cell function in mice. J Biol Chem. 2021 Jan-Jun. doi: 10.1016/j.jbc.2021.100297.

Primary Research Articles – Graduate

  • Beetch M*, Boycott C*, Yang T, Lubecka K, Ma Y, Zhang J, Kurzava Kendall L, Ullmer M, Ramsey BS, Torregrosa-Allen S, Elzey BD, Cox A, Atallah Lanman N, Hui A, Villanueva N, de Conti A, Huan T, Pogribny I, Stefanska B. Epigenetic aberrations of gene expression in a rat model of hepatocellular carcinoma. Epigenetics. 2022 May 3; 1-22. PMID: 35502615
  • Beetch M*, Boycott C*, Harandi-Zadeh S, Yang T, Martin BJE, Dixon-McDougall T, Ren K, Gacad A, Dupuis JH, Ullmer M, Lubecka K, Yada RY, Brown CJ, Howe LJ, Stefanska B. Pterostilbene leads to DNMT3B-mediated DNA methylation and silencing of OCT1-targeted oncogenes in breast cancer cells. J Nutr Biochem. 2021 Dec;98:108815. PMCID: PMC8819711

  • Harandi-Zadeh S, Boycott C, Beetch M, Yang T, Martin BJE, Ren K, Kwasniak A, Dupuis JH, Lubecka K, Yada RY, Howe LJ, Stefanska B. Pterostilbene changes epigenetic marks at enhancer regions of oncogenes in breast cancer cells. Antioxidants (Basel). 2021 Jul 30;10(8):1232. PMCID: PMC8388921

  • Beetch M,Harandi-Zadeh S, Yang T, Boycott C, Chen Y, Stefanska B, Mohammed SI. DNA methylation landscape of triple-negative ductal carcinoma in situ (DCIS) progressing to the invasive stage in canine breast cancer. Sci Rep. 2020 Feb 12. 12:1, p. 2415.

  • Beetch M, Lubecka K, Shen K, Flower K, Harandi-Zadeh S, Suderman M, Flanagan JM, Stefanska B. Stilbenoid-mediated epigenetic activation of Semaphorin 3A in breast cancer cells involves changes in dynamic interactions of DNA with DNMT3A and NF1C transcription factor. Mol Nutr Food Res. 2019 Jul 20:e1801386. doi: 10.1002/mnfr.201801386.

  • Beetch M*, Lubecka K*, Kristofzski H, Suderman M, Stefanska B. Subtle alterations in DNA methylation patterns in normal cells in response to dietary stilbenoids. Mol Nutr Food Res. 2018 May 24 ePub. Featured on cover.
  • Lubecka K, Flower K, Beetch M, Qiu J, Kurzava L, Buvala H, Ruhayel A, Gawrieh S, Liangpunsakul S, Gonzalez T, McCabe G, Chalasani N, Flanagan JM, Stefanska B. Loci-specific differences in blood DNA methylation in HBV-negative populations at risk for hepatocellular carcinoma development. Epigenetics. 2018 July 30. 13:6, pp. 605-626.