David G. Levitt, MD, PhD
Professor, Department of Integrative Biology and Physiology (IBP)
Contact Info
PhD, University of Minnesota (Physiology), 1968
Masters Degree, University of Minnesota (Medicine, MD), 1968
BS, University of Minnesota (Medicine), 1966
Research
Research Summary/Interests
I have been involved in research in large number of areas of physiology and biophysics, including: capillary exchange, small intestinal circulation and absorption, blood-tissue exchange kinetics, membrane and ion channel biophysics, ethanol pharmacokinetics, and X-ray crystallography. My current area of research interest is in pharmacokinetics, which makes use of my background in these varied fields. I recently developed PKQuest (www.pkquest.com), a new pharmacokinetic software program. I am now focused on the further development of this program and its application to a number of pharmacokinetic research areas.
Publications
Pharmacokinetic Publications:
- Levitt DG. PKQUEST: Capillary Permeability Limitation and Plasma Protein Binding - Application to Human Inulin, Dicloxacillin and Ceftriaxone Pharmacokinetics. BMC Clin Pharmacol. 2002 Sep 26
- Levitt DG. PKQuest: volatile solutes - application to enflurane, nitrous oxide, halothane, methoxyflurane and toluene pharmacokinetics.BMC Anesthesiol. 2002 Aug 15;2(1):5.
- Levitt DG. PKQuest: measurement of intestinal absorption and first pass metabolism - application to human ethanol pharmacokinetics.BMC Clin Pharmacol. 2002 Aug 15;2(1):4.
- Levitt DG. PKQuest: a general physiologically based pharmacokinetic model. Introduction and application to propranolol. BMC Clin Pharmacol. 2002 Aug 15;2(1):5.
- Levitt, DG. The Use of a Physiologically Based Pharmacokinetic Model to Evaluate Deconvolution Measurements of Systemic Absorption. BMC Clin Pharmacol. 2003, 3:1 (19 Mar 2003).
- Levitt, DG. The Pharmacokinetics of the Interstitial Space in Humans. BMC Clin Pharmacol. Submitted.