O. Douglas Wangensteen, PhD

Professor of Physiology, Pediatrics and Medicine, Department of Integrative Biology and Physiology (IBP)

O. Douglas Wangensteen

Contact Info


Mailing Address:
321 Church Street SE
6-125 Jackson Hall
Minneapolis MN 55455

Professor of Physiology, Pediatrics and Medicine, Department of Integrative Biology and Physiology (IBP)

PhD, University of Minnesota, (Physiology), 1968

BS, University of Minnesota (Chemical Engineering), 1964


Research Summary/Interests

I maintain a scholarly interest in the general area of solute and water transport across epithelial membranes in the lung. I continue to collaborate with colleagues in the Department of Medicine on studies of how the reabsorption of alveolar fluid (pulmonary edema) can be stimulated in patients with acute lung injury.


PUBMED Link to Publications

  • Bhargava, M., M.R. Runyon, D. Smirnov, J. Lei, T.J.Groppoli, C.N. Mariash, O.D. Wangensteen & D.I. Ingbar. Triiodo-l-thyronine rapidly stimulates alveolar fluid clearance in normal and hyperoxia injured lungs. Am. J. Resp. & Crit. Care Med. 178: 506-512, 2008.
  • Phillips, J.R., T. Tripp, W.E. Regelmann, P.M. Schlievert & O.D. Wangensteen. Staphylococcal ?-toxin causes increased tracheal epithelial permeability. Pediatr. Pulmon. 41: 1146-1152, 2006.
  • Panoskaltsis-Mortari, A., J.R. Hermanson, E. Taras, O.D. Wangensteen, I.F. Charo, B.J. Rollins & B.R. Blazar. (2004) Post-BMT lung injury occurs independently of the expression of CCL2 or its receptor, CCR2 on host cells. Am. J. Physiol., Lung Cell Mol. Physiol. 286: L284-L292.
  • Hotchkiss, J.R., L. Blanch, G. Murias, A.B. Adams, D.A. Olson, O.D. Wangensteen, P.H. Leo & J.J. Marini. (2000) Effects of decreased respiratory frequency on ventilator-induced lung injury. Am. J. Resp. Crit. Care Med. 161: 463-468.
  • Carter, E.P., O.D. Wangensteen, J. Dunitz and D.H. Ingbar. (1997) Hyperoxic effects on alveolar sodium resorption and lung Na,K-ATPase. Am. J. Physiol. 273: L1191-L1202.
  • Regelmann, W.R., L.A. Schneider, S.C. Fahrenkrug, B.H. Gray, S. Johnson, J.M. Herron, C.C. Clawson, D.J. Clawson and O.D. Wangensteen. (1997) Proteinase-free myeloperoxidase increases airway epithelial permeability in a whole trachea model. Pediatr. Pulmonology 24: 29-34.
  • Wangensteen, O.D., M.M. Bartlett, J.K. James, Z.-F. Yang and P.S. Low. (1996) Riboflavin-enhanced transport of serum albumin across the distal pulmonary epithelium. Pharm. Res. 13: 1861-1864.
  • Lasnier, J.M., O.D. Wangensteen, L.S. Schmitz, C.R. Gross and D.H. Ingbar. (1996) Terbutaline stimulates alveolar fluid resorption in hyperoxic lung injury. J. Appl. Physiol. 81: 1723-1729.