Jin O-Uchi, MD, PhD, FAHA, FCVS
Assistant Professor of Medicine, Cardiology

Contact Info
Assistant Professor of Medicine, Cardiology
Faculty, PhD Program in Integrative Biology and Physiology
Medical School, Jikei University School of Medicine Tokyo, Japan
Residency, Jikei University School of Medicine Tokyo, Japan
Fellowship, University of Rochester, Rochester, NY
PhD, Physiology, Jikei University School of Medicine Tokyo, Japan
Summary
Jin O-Uchi MD, PhD is Assistant Professor of Medicine at the Lillehei Heart Institute, Department of Medicine, Cardiology Division at the University of Minnesota.
Dr. O-Uchi received the MD and PhD degree from Jikei University School of Medicine in Japan. He did a postdoctoral fellowship at University of Rochester and worked as an Instructor and a Research Assistant Professor at Thomas Jefferson University. Prior to his position with the U of MN, , he was at Cardiovascular Research Center at Brown University and Rhode island Hospital as an Assistant Professor of Medicine. His research potential has been recognized at a national level by grant awards from NIH/NHLBI, NIH/NIGMS, American Heart Association (AHA) and American Physiological Society (APS). He serves on several editorial boards for publications including Frontiers in Physiology; Frontiers in Cardiovascular Medicine; Frontiers in Genetics; Frontiers in Cell and Developmental Biology; World Journal of Cardiology; Journal of Biochemistry and Molecular Biology Research; and JSM Biochemistry and Molecular Biology. Dr. O-Uchi is a Fellow of Cardiovascular Section of American Physiological Society (FCVS), and a Trustee (elected) of Japanese Physiological Society (JPS). He is a member of the and the American Heart Association (AHA), International Society for Heart Research (ISHR), American Physiological Society (APS), Biophysical Society (BPS), and Cardiac Muscle Society, among others. His research interests include cardiac excitation-contarction/metabolism coupling, heart failure, sudden cardiac death, cardiac channelopathies, and cardiac mitochondrial biology.
Come work with us! Visit https://med.umn.edu/lhi/about/jobs to see open positions in the O-Uchi lab.
Expertise
- Cardiac Electrophysiology
- Excitation-contarction/metabolism coupling
- Heart Failure
- Sudden Cardiac DeathChannelopathies
- Mitochondrial Biology.
Awards & Recognition
Professional Associations
Research
Research Summary/Interests
- Arrhythmia
- Heart Failure
- Adrenergic Signaling
- Ion Channels
- Mitochondria
Research Funding Grants
Publications
A complete list of publication can be found at NCBI
- O-Uchi J*#, Jhun BS*#, Adaniya SM, Mancini TJ, Landi AK, Cao JL, Xu X, Yoon Y, Choudhary G, Clements RT, Mende U, Sheu SS. Protein kinase D activation induces mitochondrial fragmentation and dysfunction in cardiomyocytes. J Physiol. 596(5):827-855, 2018. PMID: 29313986 (#Equal contribution) *Corresponding authors. [Cover Image]
- O-Uchi J*, Ryu SY, Jhun BS, Hurst S, Sheu SS. Mitochondrial Ion Channels/Transporters as Sensors and Regulators of Cellular Redox Signaling. Antioxid Redox Signal. 21(6):987-1006, 2014. PMID: 24180309. *Corresponding author.
- O-Uchi, J*, Jons, C*, Moss, AJ, Reumann, M, Rice, JJ., Goldenberg, I, Zareba, W, Wilde, AA, Shimizu, W, Kanters, JK, McNitt, S, Hofman, N, Robinson, JL, Lopes, CMB. (*Equal contribution).Use of Mutant-Specific Ion Channel Characteristics for Risk Stratification of Long QT Syndrome Patients. Science Translational Medicine. (2011)3(76):76ra28, 2011. [Cover Image] PMID: 21451124
- O-Uchi J*, Sasaki H, Morimoto S, Kusakari Y, Shinji H, Obata T, Hongo K, Komukai K, Kurihara S. Interaction of ?1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel. Circ Res. 102:1378-1388, 2008.PMID: 18467629 *Corresponding author.
- O-Uchi J*, Komukai K, Kusakari Y, Obata T, Hongo K, Sasaki H, Kurihara S. ?1-Adrenoceptor stimulation potentiates L-type Ca2+ current through Ca2+/calmodulin-dependent PK II (CaMKII) activation in rat ventricular myocytes. Proc Natl Acad Sci U S A. 102(26):9400-9405, 2005. PMID: 15964981 *Corresponding author
Teaching
Teaching Areas
- Cardiac Muscle Physiology
- Cardiac Electrophysiology
- Mitochondrial Biology
Clinical
Board Certifications
- National Medical Board in Japan
Clinical Interests
Arrhythmia; Heart Failure