Jin O-Uchi, MD, PhD, FAHA, FCVS

Assistant Professor of Medicine, Cardiology

Jin O-Uchi

Contact Info

Mailing Address:
2231 6th Street SE
4-132
Minneapolis, MN 55455

Lab Address:
2231 6th Street SE
B51-52
Minneapolis, MN 55455

Administrative Assistant Name
Jane Hutchins-Peterson

Administrative Email
jhutchin@umn.edu

Assistant Professor of Medicine, Cardiology

Faculty, PhD Program in Integrative Biology and Physiology


Medical School, Jikei University School of Medicine Tokyo, Japan

Residency, Jikei University School of Medicine Tokyo, Japan

Fellowship, University of Rochester, Rochester, NY

PhD, Physiology, Jikei University School of Medicine Tokyo, Japan

Summary

Jin O-Uchi MD, PhD is Assistant Professor of Medicine at the Lillehei Heart Institute, Department of Medicine, Cardiology Division at the University of Minnesota.

Dr. O-Uchi received the MD and PhD degree from Jikei University School of Medicine in Japan. He did a postdoctoral fellowship at University of Rochester and worked as an Instructor and a Research Assistant Professor at Thomas Jefferson University. Prior to his position with the U of MN, , he was at Cardiovascular Research Center at Brown University and Rhode island Hospital as an Assistant Professor of Medicine. His research potential has been recognized at a national level by grant awards from NIH/NHLBI, NIH/NIGMS, American Heart Association (AHA) and American Physiological Society (APS). He serves on several editorial boards for publications including Frontiers in Physiology; Frontiers in Cardiovascular Medicine; Frontiers in Genetics; Frontiers in Cell and Developmental Biology; World Journal of Cardiology; Journal of Biochemistry and Molecular Biology Research; and JSM Biochemistry and Molecular Biology. Dr. O-Uchi is a Fellow of Cardiovascular Section of American Physiological Society (FCVS), and a Trustee (elected) of Japanese Physiological Society (JPS). He is a member of the and the American Heart Association (AHA), International Society for Heart Research (ISHR), American Physiological Society (APS), Biophysical Society (BPS), and Cardiac Muscle Society, among others. His research interests include cardiac excitation-contarction/metabolism coupling, heart failure, sudden cardiac death, cardiac channelopathies, and cardiac mitochondrial biology.

Expertise

  • Cardiac Electrophysiology
  • Excitation-contarction/metabolism coupling
  • Heart Failure
  • Sudden Cardiac DeathChannelopathies
  • Mitochondrial Biology.

Awards & Recognition

  • Selected Speaker for “Featured Topic Session” at Experimental Biology Meeting (2019)
  • Fellow of American Heart Association, American Heart Association Basic Cardiovascular Sciences (2018)
  • Finalist, Neonatal Cardiopulmonary Biology Young Investigator Award (2018)
  • Fellow of Cardiovascular Section of American Physiological Society (2018)
  • Shih-Chun Wang Young Investigator Award, American Physiological Society (2017)
  • Oral Abstract Award, Central Society for Clinical and Translational Research (2017)
  • Finalist, Gary Lopaschuk Young Faculty Award, International Academy of Cardiovascular Sciences (2016)
  • New investigator Award, American Physiological Society, Cell and Molecular Physiology Section (2015)
  • Early Career Investigator Travel Awards, International Society for Heart Research (2013)
  • Research Career Enhancement Award, American Physiological Society (2013)
  • Finalist, Outstanding Early Career Investigator Award AHA, Basic Cardiovascular Sciences (2012)
  • Hiroshi and Aya Irisawa Memorial Promotion Award Physiological Society of Japan for Young Scientists (2011)
  • Richard J. Bing Award, International Society for Heart Research, (2012)
  • Postdoctoral Fellowship Award, American Heart Association (2009)
  • Promotion Award, Physiological Society of Japan (2009)
  • Foreign study Award, Kanae Foundation, Tokyo Japan (2008)
  • Graduate Student Best Paper Award, Jikei University School of Medicine (2007)
  • Research Grant Award, Jikei University School of Medicine (2007)
  • Medical Science Research Award, Kato Memorial Bioscience Foundation (2007)
  • Trustee (elected) of Physiological Society of Japan (2006)
  • Young Investigator Award, International Academy of Cardiovascular Sciences, Japan Section (2006)
  • Young Investigator's Research Award, Japan Heart Foundation (2006)
  • Fellowship Award, Japan Foundation of Cardiovascular Research (2006)
  • Travel Grant Award, Inoue Foundation for Science (2006)
  • Travel Grant Award, Kato Memorial Bioscience Foundation (2006)
  • Best Oral Presentation Award, International Society for Heart Research, Japanese Section (2005)
  • Travel Grant Award, The Naito Foundation (2005)
  • Young Investigator's Travel Grant Award, Jikei Alumni Association (2005)
  • Graduate Student's Research Award, Jikei University School of Medicine (2005)

Professional Associations

  • Member of Career Opportunities in Physiology Committee, American Physiological Society, Cardiovascular Section (2020-present)
  • Ad-hoc Peer Grant Reviewer, Medical Research Council UK Research and Innovation (2019-present)
  • Member of Awards Selection Committee, American Physiological Society, Cardiovascular Section (2018-present)
  • Member of Peer Grant Review Committee, American Heart Association (2018-present)
  • Heart Rhythm Society
  • Central Society for Clinical and Translational Research (CSCTR)
  • American Heart Association (AHA)
  • International Society for Heart Research (ISHR)
  • Society of Cardiovascular Anesthesiologists (SCA)
  • International Academy of Cardiovascular Sciences (IACS)
  • Cardiac Muscle Society
  • American Physiological Society (APS)
  • Society of General Physiologist (SGP)
  • Biophysical Society (BPS)
  • Japanese Circulation Society
  • Japanese So

Research

Research Summary/Interests

  • Arrhythmia
  • Heart Failure
  • Adrenergic Signaling
  • Ion Channels
  • Mitochondria

Research Funding Grants

  • Office of Academic Clinical Affairs (OACA) COVID-19 Response Grant
    "Magnesium supplementation for preventing sudden cardiac death by COVID-19 viroporins in patients with pre-existing hypertension"
    The goal of this pilot project is to test the efficacy of clinically approved magnesium (Mg) supplementation for preventing sudden cardiac death in COVID-19 with pre-existing hypertension.
  • NIH/NHLBI R01HL148727 Choudhary (PI), O-uchi (Subaward PI)
    “Role of Endothelial Anoctamin-1 in Pulmonary Arterial Hypertension”
    The major goal of this project is to clarify the role of novel mitochondrial Cl -channel Anoctamin-1 in the development of pulmonary arterial hypertension.
  • VA BLR&D ULM-004-18S MERIT REVIEW Choudhary (PI), O-Uchi (Co-I)
    Please revise the grant number to "CX001892"
  • NIH/NHLBI R01HL135236 Clements (PI), O-Uchi (Subaward PI)
    “Surgical Cardioprotection Through BKCa-Dependent Modulation of Mitochondrial Supercomplexes”
    The major goal of this project is to clarify the molecular mechanism underlying mitochondrial BK channel-mediated regulation of supercomplex formation in mitochondrial electron transport chain and its contribution for the surgical cardioprotection in vivo.
  • NIH/NHLBI R01HL142588 Terentyev (PI), O-Uchi (Subaward PI)
    “Novel Mechanisms of Regulation of SK channels: Implications for Cardiac Arrhythmia”
    The major goal of this project is to clarify the regulatory mechanism for mitochondrial SK and its contribution for the cardiac arrhythmia in heart failure.
  • IEM Group Program Grant Talkachova, O-Uchi, Dudley (M-PIs)
    “Cardiac working Group targeting multi-scale mechanisms of arrhythmia”
    This project is to establish a strong multidisciplinary research team within our institution, that will be able to investigate the novel mechanisms of cardiac arrhythmias in the heart at all levels including  molecular, cellular, tissue/organ, and in vivo scale.
  • APS Hearst Undergraduate Summer Research Fellows Tsobze (PI), O-Uchi (sponsor)
    “Role of Mitochondrial Proline rich Tyrosine Kinase 2 (PyK2) inhibitory peptide in modulating Mitochondrial Ca2+ overload”
    This project is to test the effect of mitochondrial matrix targeted Pyk2 inhibitory peptide on mitochondrial Ca2+ handing and ROS generation using cell culture system.
  • VA BLR&D ULM-004-18S MERIT REVIEW Choudhary (PI), O-Uchi (Co-I)
    “Role of Skeletal Muscle Mitochondrial Supercomplexes in Exercise Intolerance”
    The major goal of this project is to clarify the molecular mechanism underlying supercomplex formation in mitochondrial electron transport chain in skeletal muscles and its contribution for the generation of the exercise Intolerance in pulmonary hypertension patients.
  • R01HL136757 O-Uchi (PI) “Regulation of mitochondrial calcium uniporter in the heart” This project is to elucidate the role of a newly identified short transcript variant of the mitochondrial Ca2+ uniporter (MCU-S) in the regulation of cellular metabolism, mitochondrial Ca2+ handling, ROS production and apoptotic death in the heart. No scientific overlap with proposed project. Role: PI
  • 16SDG27260248 AHA Scientist Development Grant (SDG) O-Uchi (PI) “Role of mitochondrial RyR1 in cardiac arrhythmia and sudden cardiac death” This project investigates the detailed mechanism underlying the generation of cardiac arrhythmias and sudden cardiac death in malignant hyperthermia (MH) using knock-in mice carrying a RyR1 mutation Y522S (YS mice) found in the human MH family. No scientific overlap with proposed project. Role: PI
  •  2017 APS Shih-Chun Wang Young Investigator Award O-Uchi (PI) This Award is given annually to an individual demonstrating outstanding promise based on their research program in the physiological sciences. The award is designated for use in the Awardee's research program. No scientific overlap with proposed project. Role: PI

Publications

A complete list of publication can be found at NCBI

  • O-Uchi J*#, Jhun BS*#, Adaniya SM, Mancini TJ, Landi AK, Cao JL, Xu X, Yoon Y, Choudhary G, Clements RT, Mende U, Sheu SS. Protein kinase D activation induces mitochondrial fragmentation and dysfunction in cardiomyocytes. J Physiol. 596(5):827-855, 2018. PMID: 29313986 (#Equal contribution) *Corresponding authors. [Cover Image]
  • O-Uchi J*, Ryu SY, Jhun BS, Hurst S, Sheu SS. Mitochondrial Ion Channels/Transporters as Sensors and Regulators of Cellular Redox Signaling. Antioxid Redox Signal. 21(6):987-1006, 2014. PMID: 24180309. *Corresponding author.
  • O-Uchi, J*, Jons, C*, Moss, AJ, Reumann, M, Rice, JJ., Goldenberg, I, Zareba, W, Wilde, AA, Shimizu, W, Kanters, JK, McNitt, S, Hofman, N, Robinson, JL, Lopes, CMB. (*Equal contribution).Use of Mutant-Specific Ion Channel Characteristics for Risk Stratification of Long QT Syndrome Patients. Science Translational Medicine. (2011)3(76):76ra28, 2011. [Cover Image] PMID: 21451124
  •  O-Uchi J*, Sasaki H, Morimoto S, Kusakari Y, Shinji H, Obata T, Hongo K, Komukai K, Kurihara S. Interaction of ?1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel. Circ Res. 102:1378-1388, 2008.PMID: 18467629 *Corresponding author.
  • O-Uchi J*, Komukai K, Kusakari Y, Obata T, Hongo K, Sasaki H, Kurihara S. ?1-Adrenoceptor stimulation potentiates L-type Ca2+ current through Ca2+/calmodulin-dependent PK II (CaMKII) activation in rat ventricular myocytes. Proc Natl Acad Sci U S A. 102(26):9400-9405, 2005. PMID: 15964981 *Corresponding author

Teaching

Teaching Areas

  • Cardiac Muscle Physiology
  • Cardiac Electrophysiology
  • Mitochondrial Biology

Clinical

Board Certifications

  • National Medical Board in Japan

Clinical Interests

Arrhythmia; Heart Failure