Robert P. Hebbel, MD
Regents Professor Emeritus, Division of Hematology, Oncology and Transplantation

Contact Info
Regents Professor Emeritus, Division of Hematology, Oncology and Transplantation
Faculty, PhD Program in Integrative Biology and Physiology
Medical School, University of Minnesota, Minneapolis, MN
Residency, University of Washington, Seattle, WA
Fellowship, University of Minnesota, Minneapolis, MN
Summary
Expertise
- Hematology
- Red cell disorders
- Sickle cell anemia
- Endothelial and vascular biology
Awards & Recognition
Professional Associations
Scholarly Activities
Research
Research Summary/Interests
Dr. Hebbel's research interests include: the vascular pathobiology of sickle disease; use of blood outgrowth endothelial cells (BOEC) for biomedical applications; and the role of genetically determined differences in endothelial biology as a determinant of clinical phenotypic heterogeneity of vascular disease. Dr. Hebbel's lab is currently emphasizing, respectively, the molecular physiology of tissue factor expression by endothelial cells, utility of BOEC for gene therapy and device coating, and role of inherited endothelial cell differences underlying stroke risk.
Research Interest
Vascular pathobiology of sickle cell anemia; Genetic determinants of inter-individual differences in endothelial biology; Endothelial-based gene therapy
Research Funding Grants
Continuously funded by National Institutes of Health since 1979
- NIH “Heme toxicity and vaso-occlusion in sickle cell disease” (Co-Investigator)
Publications
- Solovey A, Lin Y, Browne P, Choong S, Wayner E, Hebbel RP: Circulating activated endothelial cells in sickle cell anemia. New Engl J Med 337:1584-1590, 1997.
- Lin Y, Weisdorf DJ, Solovey A, Hebbel RP: Origins of circulating endothelial cells and endothelial outgrowth from blood. J Clin Invest 105:71-77, 2000.
- Milbauer L, Wei P, Enenstein J, Jiang A, Hillery CA, Scott JP, Nelson SC, Bodempudi V, Topper JN, Yang RB, Hirsch B, Pan W, Hebbel RP. Genetic endothelial systems biology of sickle stroke risk. Blood 111:3872-3879, 2008.
- Hebbel RP, Wei P, Milbauer L, Corban MT, Solovey A, Kiley J, Patee J, Lerman LO, Pan W, Lerman A. Abnormal endothelial gene expression associated with early coronary atherosclerosis. J American Heart Assoc. 2020;9(14):016134"
- Hebbel RP, Vercellotti GM: Pathobiology of Sickle Cell Disease. In: Hematology: Basic Principles and Practice, 7th Edition. Eds, Hoffman R, Benz EJ, Silberstein LE, Weitz JI, Heslop H, Anastasi J, Salama ME. Elsevier, Philadelphia. pp 571-583, 2018
Teaching
Academic Interests and Focus
Clinical
Clinical Interests
Sickle cell anemia