Stephanie Groman, PhD
Assistant Professor, Department of Neuroscience
Dr. Groman's research is aimed at understanding the neurobiology and neurodevelopmental mechanisms of decision making to identify biological targets that could be manipulated to prevent and treat mental illness. She received her Ph.D. in 2013 from the Department of Psychology at the University of California, Los Angeles where she trained under Dr. J. David Jentsch and Dr. Edythe London. Her work integrated neuroimaging, behavioral, pharmacological andex vivoapproaches to provide the first evidence that chronic exposure to methamphetamine resulted in the neural and behavioral alterations that had been previously observed in substance-dependent individuals. Her work was recognized by several awards, including a predoctoral NIH NRSA fellowship, the UCLA Brain Research Institute Award and the Joseph A. Gengerelli Distinguished Dissertation Award. She accepted a post-doctoral position in the Department of Psychiatry at Yale University where she trained under Dr. Jane Taylor in studies investigating the biobehavioral mechanisms of addiction. In 2016 Dr. Groman was promoted to Associate Research Scientists at Yale University where her work has focused on understanding the neural circuits of decision-making and addiction. She integrates computational approaches with neuroimaging, proteomics, and drug self-administration in rodents to provide a translational platform for understanding the biological and neurodevelopmental mechanisms of addiction vulnerability. The Groman Lab in the Department of Neuroscience at the University of Minnesota will be a part of the Medical Discovery Team on Addiction and focused on identifying the neural and developmental mechanisms of addiction susceptibility.
Villiamma P, Casby J, Groman SM. Adolescent reinforcement-learning trajectories predict cocaine-taking behaviors in adult male and female rats. Psychopharmacology (Berl). 2022 Sep;239(9):2885-2901. doi: 10.1007/s00213-022-06174-w. Epub 2022 Jun 16.
Young JW, Barback CV, Stolz LA, Groman SM, Vera DR, Hoh C, Kotta KK, Minassian A, Powell SB, Brody AL. MicroPET evidence for a hypersensitive neuroinflammatory profile of gp120 mouse model of HIV. Psychiatry Res Neuroimaging. 2022 Apr;321:111445. doi: 10.1016/j.pscychresns.2022.111445
Rossano S, Toyonaga T, Berg E, Lorence I, Fowles K, Nabulsi N, Ropchan J, Li S, Ye Y, Felchner Z, Kukis D, Huang Y, Benveniste H, Tarantal AF, Groman SM, Carson RE. Imaging the fetal nonhuman primate brain with SV2A positron emission tomography (PET). Eur J Nucl Med Mol Imaging. 2022 Sep;49(11):3679-3691. doi: 10.1007/s00259-022-05825-6.
Groman SM, Thompson SL, Lee D, Taylor JR. Reinforcement learning detuned in addiction: integrative and translational approaches. Trends Neurosci. 2022 Feb;45(2):96-105. doi: 10.1016/j.tins.2021.11.007.
Groman SM, Lee D, Taylor JR. Unlocking the reinforcement-learning circuits of the orbitofrontal cortex. Behav Neurosci. 2021 Apr;135(2):120-128. doi: 10.1037/bne0000414.
Suthaharan P, Reed EJ, Leptourgos P, Kenney JG, Uddenberg S, Mathys CD, Litman L, Robinson J, Moss AJ, Taylor JR, Groman SM, Corlett PR. Paranoia and belief updating during the COVID-19 crisis. Nat Hum Behav. 2021 Sep;5(9):1190-1202. doi: 10.1038/s41562-021-01176-8.
Gianessi CA, Groman SM, Taylor JR. The effects of fatty acid amide hydrolase inhibition and monoacylglycerol lipase inhibition on habit formation in mice. Eur J Neurosci. 2022 Feb;55(4):922-938. doi: 10.1111/ejn.15129.
Groman SM. Astrocytic Activation to Restore Goal-Directed Behaviors. Biol Psychiatry. 2020 Nov 15;88(10):744-745. doi: 10.1016/j.biopsych.2020.07.024
Moin Afshar M.A.*, Keip A.J.*, Taylor J.R., Lee D., and Groman S.M. (2020) Adolescent-related changes in reinforcement learning and decision making in the rat. Journal of Neuroscience. 40(30):5857-5870. * indicates equal author contribution.
Groman S.M., Hillmer A., Liu H., Fowles K., Holden D., Morris E.D., Lee D., and Taylor J.R. (2020) Dysregulation of decision-making related to mGluR5, but not D 3 receptor, availability following cocaine self-administration in rats. In press at Biological Psychiatry.
Bond C.W., Foscue E., Groman S.M., Trinko J.R., Taylor J.R., and DiLeone R.J. (2020) Medial nucleus accumbens projections to the ventral tegmental area control food consumption. Journal of Neuroscience. 40(24): 4727-4738.
Groman S.M., Hillmer A., Liu H., Fowles K., Holden D., Morris E.D., Lee D., and Taylor J.R. (2020) Midbrain D3 receptor availability predicts escalation in cocaine self-administration. In press at Biological Psychiatry.
Reed E.J., Uddenberg S., Mathys C.D., Taylor J.R., Groman S.M., and Corlett P.R. (2020) Expecting the unexpected: the paranoid style of belief updating across species. In press at eLIFE.
Groman S.M., Keistler, C., Keip A., Hammarlund E., DiLeone R.J., Piitenger C., Lee D., and Taylor J.R. (2019) Orbitofrontal circuits make distinct contributions to flexible decision-making. Neuron. 103(4):734-746.
Gianessi C., Groman S.M., Thompson S.L., Jiang M., van der Stelt M., and Taylor J.R (2019) Endocannabinoid contributions to alcohol habits and motivation: relevance to treatment. Addiction Biology. 25(3).
Groman S.M., Massi B., Mathias S.R., Lee D., and Taylor J.R. (2019) Model free and model-based influences in addiction. Biological Psychiatry. 85(11): 936-945.
Groman S.M., Massi B., Mathias S., Curry D., Lee D., and Taylor J.R. (2019) Neurochemical and behavioral dissections of decision-making in a rodent multi-stage task. Journal of Neuroscience. 39(2): 295-306.
Gianessi C., Groman S.M., and Taylor J.R. (2018) Bidirectional modulation of food habit expression by the endocannabinoid system. European Journal of Neuroscience. 49(12):1610-1622.