Jesse Williams, PhD

Assistant Professor, Integrative Biology & Physiology,

Jesse Williams

Contact Info

jww@umn.edu

Office Phone 612-625-3109

Office Address:
3-144 Wmbb
2101 6th St SE
Minneapolis, MN 55455-3008

Mailing Address:
3-144 Wmbb
2101 6th St SE
Minneapolis, MN 55455-3008

Lab Address:
Wallin Medical Biosciences Building
2101 6th St SE
Minneapolis, MN 55414

Postdoctoral Fellowship, Division of Pathology and Immunology, Washington University in St. Louis, 2019

PhD, Molecular Pathology and Molecular Medicine/Immunology, University of Chicago, 2013

BA, DePauw University, 2007

Summary

Awards & Recognition

International Conference on Lipid and Atherosclerosis (ICoLA), Best Oral Presentation, 2018

American Heart Association, Postdoctoral Fellowship, 2016

Robert E. Priest Fellowship, University of Chicago, Department of Pathology, 2012

Research

Research Summary/Interests

My lab is interested in understanding the contribution of myeloid cells in the pathogenesis of metabolic and cardiovascular diseases, like atherosclerosis. We aim to determine mechanisms regulating the development and function of tissue-resident macrophages, as well as fate-decisions of circulating monocytes upon entry into inflamed tissues.

Research Funding Grants

NIH, National Heart, Lung, and Blood Institute K99/R00 HL138163 “Atherosclerotic Lesion Initiation by Resident Aortic Macrophage Proliferation and Lipid Uptake

Publications

Williams, J. W., Zaitzev, K., Kim, K.-w., Ivanov, S., Saunders, B., Kim, K., Elvington, A., Schrank, P. R., Wohltmann, M., Epelman, S., Artyomov, M., Lavine, K., Zinselmeyer, B., Choi, J.-H., & Randolph, G. J. (2020). Limited Proliferation Capacity of Aorta Intima Resident Macrophages Requires Monocyte Recruitment for Atherosclerotic Plaque Progression. Nature Immunology, 21(10), 1194-1204.

Williams, J. W., Huang, L.-h., & Randolph, G. J. (2019). Cytokine Circuits in Cardiovascular Disease. Immunity, 50(4), 941--954.

Williams, J. W., Martel, C., Potteaux, S., Esaulova, E., Ingersoll, M. A., Elvington, A., Saunders, B. T., Huang, L.-H., Habenicht, A. J., Zinselmeyer, B. H., & others (2018). Limited Macrophage Positional Dynamics in Progressing or Regressing Murine Atherosclerotic Plaques—brief report. Arteriosclerosis, thrombosis, and vascular biology (ATVB), 38(8), 1702—1710

Williams, J. W., Giannarelli, C., Rahman, A., Randolph, G. J., & Kovacic, J. C. (2018). Macrophage Biology, Classification, and Phenotype in Cardiovascular Disease: JACC Macrophage in CVD Series (part 1). Journal of the American College of Cardiology, 72(18), 2166--2180

Williams, J. W., Elvington, A., Ivanov, S., Kessler, S., Luehmann, H., Baba, O., Saunders, B. T., Kim, K.-W., Johnson, M. W., Craft, C. S., & others (2017). Thermoneutrality but Not UCP1 Deficiency Suppresses Monocyte Mobilization Into Blood. Circulation Research, 121(6), 662--676.