Anudeep Yekula, MBBS

Resident PGY1, Department of Neurosurgery

Anudeep Yekula

Contact Info

MD, MBBS, Guntur Medical College, India

Sub-internship, neurological surgery, Massachusetts General Hospital, Boston

Sub-internship, vascular surgery, Massachusetts General Hospital, Boston

Sub-internship, surgical oncology, Massachusetts General Hospital, Boston

Internship, general surgery, Yale-New Haven Hospital, Connecticut

Summary

Dr. Yekula graduated from Guntur Medical College, India, as a valedictorian with several gold medals and scholarships. He then completed sub-internships in neurological surgery, vascular surgery, and surgical oncology, all at Massachusetts General Hospital in Boston. Dr. Yekula also completed a general surgery internship at the Yale-New Haven Hospital, which is affiliated with the Yale School of Medicine in Connecticut.

To build his research skills, Dr. Yekula worked as a post-doctoral research fellow with Bob Carter, MD, PhD; and Leonora Balaj, PhD, at the Center of Excellence for Research in Exosome Sciences laboratory of Massachusetts General Hospital/Harvard Medical School, developing blood-based tests for the diagnosis and monitoring of brain tumors. He has developed novel diagnostic assays that are currently undergoing clinical translation and is also a co-inventor of two innovation patents. During his time at Yale, Dr. Yekula worked with Dr. Naiem Nassiri studying vascular malformations and endovascular stent-graft devices. Dr. Yekula has more than 28 peer-reviewed articles published in medical journals (he is first author on 12) and has made numerous poster and oral presentations during medical meetings throughout the world.

He also spent time volunteering organizing health camps while in school and was an active member of the Recruitment and Diversity Committee for Yale.

When he has free time, Dr. Yekula enjoys cooking Indian and Middle Eastern foods, writing poetry and short fiction, travelling and taking long drives, and playing billiards.

Awards & Recognition

  • CNS Journal of Neuro-oncology Award, 2021
  • CNS Best Basic Science Award, 2020
  • Honors in General/GI Surgery Sub-I, Massachusetts General Hospital (MGH), 2018
  • High Honors with Distinction in Neurosurgery Sub-I, MGH, 2017
  • 21 gold medals

Professional Associations

  • Congress of Neurological Surgeons
  • International Society for Extracellular Vesicles
  • American Society of Clinical Oncology
  • Society of Neuro-Oncology

Languages

  • Hindi

Research

Publications

Peer Reviewed Journal Articles/Abstracts

  1. Yekula, A., Inturu, S., Jain, S., Yekula, A., Kotha, A., Pasula, A., Yekula KK. Benign Sacrococcygeal Teratoma in Adults: A Systematic Review of the Literature. Acta Scientific Neurology. (2021); 4(6): 96-101. Pub Status: Published.
  2. Yekula, A., Kitchen, R., Chakrabortty, S., Carter, B., Breakefield, Xandra., Skog, J., Balaj, L. Liquid Biopsy for Patient Stratification and Monitoring of Dacomitinib Clinical Trial in Patients with EGFR Amplified Recurrent Glioblastoma. Cancer Research. (2021); 81(13): 456. Pub Status: Published.
  3. Yekula, A., Kitchen, R., Chakrabortty, S., Carter, B., Breakefield, Xandra., Skog, J., Balaj, L. Liquid Biopsy for Patient Stratification and Monitoring of Dacomitinib Clinical Trial in Patients with EGFR Amplified Recurrent Glioblastoma. Neuro-Oncology Advances. (2021); 3(2): 7. Cited in PubMed; PMID: 8255422. Pub Status: Published.
  4. Muralidharan, K., Yekula, A., Kang, K.M., Small, J.L., Rosh, Z.S., Wang, L., Lau, S., Zhang, H., Lee, H., Bettegowda, C., Chicoine, M.R., Kalkanis, S.N., Shankar, G.M., Nahed, B.V., Curry, W.T., Jones, P.S., Cahill, D.P., Balaj, L., Carter, B.S. TERT Promoter Mutation for Blood-based Diagnosis and Monitoring of Gliomas. Clinical Cancer Research. (2021); 27(1): 169-178. Cited in PubMed; PMID: 33051308. Pub Status: Published.
  5. Kang, K.M., Muralidharan, K., Yekula, A., Small, J.L., Rosh, Z.S., Jones, P.S., Carter, B.S., Balaj, L. Blood-based Detection of BRAF V600E in Gliomas and Brain Tumor Metastasis. Cancers. (2021); 13(6): 1227-1232. Cited in PubMed; PMID: 33799709. Pub Status: Published.
  6. Gupta, M., Yekula, A., Barba, D., Pannell, J.S., Tomalin, J. Traumatic Ischemic Injury in a Top of the Basilar Distribution. BMC Neurology. (2021); 21(1): 178-180. Cited in PubMed; PMID: 33902491. Pub Status: Published.
  7. Gupta, M., Sagi, V., Mittal, A., Yekula, A., Hawkins, D., Shimizu, J., Duddleston, P.J., Thomas, K., Goetsch, S.J., Alksne, J.F., Ott, K., Shimizu, K.T., Duma, C., Ben-Haim, S. Results of Three or More Gamma Knife Radiosurgery Procedures for Recurrent Trigeminal Neuralgia. Journal of Neurosurgery. (2021); 10(2): 31-34. Pub Status: Published.
  8. Yekula, A., Mittal, A., Sagi, V., Gupta, M. External Ventricular Drains: An Overview of Indications, Technique, and Complications. Acta Scientific Neurology. (2020); 3(7): 16-22. Pub Status: Published.
  9. Yekula, A., Muralidharan, K., Kang, K.M., Carter, B.S., Balaj, L. Extracellular Vesicles in Glioblastoma Tumor Microenvironment. Frontiers in Immunology. (2020); 10(-): 3137. Cited in PubMed; PMID: 32038644. Pub Status: Published.
  10. Yekula, A., Muralidharan, K., Kang, K.M., Wang, L., Carter, B.S., Balaj, L. From Laboratory to Clinic: Translation of Extracellular Vesicle Based Cancer Biomarkers. Methods, Elsevier. (2020); 177(-): 58-66. Cited in PubMed; PMID: 32061674. Pub Status: Published.
  11. Mass, S.L.N., Solinge, T.V., Schnoor, R., Yekula, A., De Vrij, J., Robe, P., Balaj, L., Arkestein, G.J.A., Nolte-‘t Hoen, E.N.M. Broekman, M. Orally Administered 5-Aminolevulinic Acid for Isolation and Characterization of Circulating Tumor Derived Extracellular Vesicles in Glioblastoma Patients. Cancers. (2020); 12(11): 3297-3302. Cited in PubMed; PMID: 33171819. Pub Status: Published.
  12. Gupta, M., Chan, T.M., Santiago-Dieppa, D.R., Yekula, A., Sanchez, C., Crawford, J.R., Levy, M.L., Gonda, D.D. Robot-Assisted Stereotactic Biopsy of Paediatric Brainstem and Thalamic Lesions. Journal of Neurosurgery: Pediatrics. (2020); 25(1): 1-8. Cited in PubMed; PMID: 33361479. Pub Status: Published.
  13. Gupta, M., Sagi, V., Mittal, A., Yekula, A., Hawkins, D., Shimizu, J., Duddleston, P.J., Thomas, K., Goetsch, S.J., Alksne, J.F., Ott, K., Shimizu, K.T., Duma, C., Ben-Haim, S. Results of Multiple Gamma Knife Radiosurgery Treatments for Recurrent Trigeminal Neuralgia. Neurosurgery. (2020); 67(1): 530. Pub Status: Published.
  14. Sadegh, Cameron., Talati, Pratik., Yekula, A., Schleicher, R., Koch, M.J., Stapleton, C.J., Patel, A.B., Carter, B.S., Balaj, L.B, Kimberly, Taylor., Lehtinen, M.K., Altered CSF Ionic Homeostasis Predicts Persistent Hydrocephalus After Aneurysmal Subarachnoid Hemorrhage. Neurosurgery. (2020); 67(1): 312. Pub Status: Published.
  15. Wang, L*., Yekula, A*., Muralidharan, K., Small, J., Rosh, Z., Carter, B.S., Balaj, L. (*co-first authors). Novel Gene Fusions in Glioblastoma Tumor Tissue and Matched Patient Plasma. Cancers. (2020); 12(5): 1219. Cited in PubMed; PMID: 32414213. Pub Status: Published.
  16. Yekula, A., & Gupta, M. Primary Central Nervous System Lymphoma: ‘The Great Imitator’. Acta Scientific Neurology. (2020); 3(6): 1-2. Pub Status: Published.
  17. Kang, K.M., Muralidharan, K., Knowlton, H.T., Hassan, K., Yekula, A., Swearingen, B., Jones, P.S. The Utility of Bilateral Inferior Petrosal Sinus Sampling for Diagnosis and Lateralization of Cushing’s Disease in the Pediatric Population. Journal of Neurosurgery: Pediatrics. (2020); 67(1): 199. Pub Status: Published.
  18. Yekula, A., Muralidharan, K., Rosh, Z., Youngkin, A.E., Carter, B.S., Balaj, L. Liquid Biopsy Strategies to Distinguish Progression from Pseudoprogression and Radiation Necrosis in Glioblastomas. Advanced Biosystems. (2020); 4(12): 29-31. Cited in PubMed; PMID: 32484293. Pub Status: Published.
  19. Yekula, A., Taylor, A., Beecroft, A., Kang, K.M., Small, J.S., Muralidharan, K., Rosh, Z., Carter, B.S., Balaj, L. The Role of Extracellular Vesicles in Acquisition of Resistance to Therapy in Glioblastoma. Cancer Drug Resistance. (2020); 3(-): 61-65. Pub Status: Published.
  20. Yekula, A., Grant, C., Gupta, M., Santiago-Dieppa, D.R., Duddleston, P.J., Gonda, D., Levy, M. Clinical and Genetic Characterization of Patients with Pierre Robin Sequence and Spinal Disease: Review of the literature and Novel Terminal 10q Deletion. Childs Nervous System. (2020); 36(7): 1367-1377. Cited in PubMed; PMID: 32399800. Pub Status: Published.
  21. Yekula, A., Gupta, M., Coley, N., U, H.S. Adult H3K27M-Mutant Diffuse Midline Glioma with Gliomatosis Cerebri Growth Pattern. International Journal of Surgery Case Reports. (2020); 68(-): 124-128. Cited in PubMed; PMID: 32145563. Pub Status: Published.
  22. Gupta, M., Sagi, V., Yekula, A., Golts, E., Lane, J.S., Pannell, J.S. Vertebral Artery Stump Syndrome due to Chronic Complicated Aortic Dissection: A Case Report. World Neurosurgery. (2020); 145(1): 295-297. Cited in PubMed; PMID: 33011356. Pub Status: Published.
  23. Gupta, M., Yekula, A., Sagi, V., Mittal, A., Schwartz, M.S. Squamous Cell Carcinoma of the Scalp Causing Cortical Venous Thrombosis and Intraparenchymal Hematoma. eNeurologicalSci. (2020); 20(1): 51-53. Cited in PubMed; PMID: 32613095. Pub Status: Published.
  24. Gupta, M., Yekula, A., Duddleston, P.J., Sagi, V., Powers, M.P., U, H.S. Null Cell Pituitary Adenoma of the Clivus and Sphenoid Sinus: Case Report and Systematic Review of the Literature. Acta Scientific Neurology. (2019); 2(9): 66-70. Pub Status: Published.
  25. Jones, P.S*., Yekula, A*., Lansbury, E., Small, J.L., Ayinon, C., Mordecai, S., Hochberg, F.H., Tigges, J., Delcuze, B., Charest, A., Gihran, I., Balaj, L., Carter, B.S. (*co-first authors). Characterization of Plasma-derived Protoporphyrin-IX-positive Extracellular Vesicles Following 5-ALA Use in Patients with Malignant Glioma. EBioMedicine, Lancet. (2019); 48(-): 23-35. Cited in PubMed; PMID: 31628025. Pub Status: Published.
  26. Roy, S., Lin, H.Y., Chou, C.Y., Huang, C.H., Small, J., Sadik, N., Ayinon, C., Lansbury, E., Cruz, L., Yekula, A., Jones, P.S., Balaj, L., Carter, B.S. Navigating the Landscape of Tumor Extracellular Vesicle Heterogeneity. International Journal of Molecular Sciences. (2019); 20(6): 1349. Cited in PubMed; PMID: 30889795. Pub Status: Published.
  27. Yekula, A., Minciacchi, V.R., Morello, M., Shao, H., Park, Y., Zhang, X., Muralidharan, K., Freeman, M.R., Weissleder, R., Lee, H., Carter, B.S., Breakefield, X.O., Di Vizio, D., Balaj, L. Large and Small Extracellular Vesicles Released by Glioma Cells in Vitro and In Vivo. Journal of Extracellular Vesicles. (2019); 9(1): 1689784. Cited in PubMed; PMID: 31839905. Pub Status: Published.
  28. Yekula, K.K. & Yekula, A. Adult Sacrococcygeal Teratoma: The Third Leg: A Rare Case Report in a 25-Year-Old Man. International Journal of Surgery Case Reports. (2015); 14(-): 146-148. Cited in PubMed; PMID: 26275739. Pub Status: Published.

Poster Presentations

  1. Yekula, A., Muralidharan, K., Kang, K.M., Small, J.L., Rosh, Z.S., Wang, L., Lau, S., Zhang, H., Lee, H., Bettegowda, C., Chicoine, M.R., Kalkanis, S.N., Shankar, G.M., Nahed, B.V., Curry, W.T., Jones, P.S., Cahill, D.P., Balaj, L., Carter, B.S. (2021, October). TERT Promoter Mutation for Blood-based Diagnosis and Monitoring of Gliomas Poster presented at: Congress of Neurological Surgeons Annual Meeting 2021; Austin, TX.
  2. Yekula, A., Hsia, T., Carter, B.S., Balaj, L. (2021, November). Development of 5-ALA based liquid biopsy for the non-invasive diagnosis of glioblastoma Poster presented at: Society of Neuro-Oncology Annual Meeting 2021; Boston, MA.
  3. Yekula, A., Kitchen, R., Chakrabortty, S., Carter, B., Breakefield, Xandra., Skog, J., Balaj, L. (2021, April). Analysis of serum-derived extracellular RNA to monitor treatment response to dacomitinib in adult patients with EGFR amplified recurrent glioblastoma (Finalist) Poster presented at: Scientific Advisory Committee (SAC) Annual Meeting 2021; Boston, MA.
  4. Yekula, A., Kitchen, R., Chakrabortty, S., Carter, B., Breakefield, Xandra., Skog, J., Balaj, L. (2021, April). Liquid biopsy for patient stratification and monitoring of dacomitinib clinical trial in patients with EGFR amplified recurrent glioblastoma Poster presented at: American Association of Cancer Research AACR Annual Meeting 2021; Boston, MA.
  5. Yekula, A., Muralidharan, K., Carter, B.S., Balaj, L. (2020, May). Dissecting the Heterogeneity of Extracellular Vesicle Sub-populations at Single EV Level. Poster presented at: International Society of Extracellular Vesicles ISEV Annual Meeting 2020; Philadelphia, PA.
  6. Yekula, A., Muralidharan, K., Kang, K.M., Small, J.L., Rosh, Z.S., Wang, L., Lau, S., Zhang, H., Lee, H., Bettegowda, C., Chicoine, M.R., Kalkanis, S.N., Shankar, G.M., Nahed, B.V., Curry, W.T., Jones, P.S., Cahill, D.P., Balaj, L., Carter, B.S. (2020, May). TERT Promoter Mutation for Blood-based Diagnosis and Monitoring of Gliomas Poster presented at: Clinical Research Day 2020, Massachusetts General Hospital, Harvard Medical School; Boston, MA.
  7. Yekula, A., Wang, L., Muralidharan, K., Small, J., Rosh, Z., Carter, B.S., Balaj, L. (2020, October). Novel Gene Fusions in Glioma Tumor Tissue and Matched Patient Plasma. Poster presented at: Clinical Research Day 2020, Massachusetts General Hospital, Harvard Medical School; Boston, MA.
  8. Yekula, A., Jones, P.S., Lansbury, E., Balaj, L., Carter, B.S. (2019, October). Characterization of Fluorescent Extracellular Vesicles Following 5-ALA use in Patients with Malignant Glioma. Poster presented at: Scientific Advisory Committee SAC Annual Meeting 2019, Massachusetts General Hospital, Harvard Medical School; Boston, MA.
  9. Yekula, A., Jones, P.S., Lansbury, E., Small, J.L., Hochberg, F.H., Tigges, J., Delcuze, B., Charest, A., Ghiran, I., Balaj, L., Carter, B.S. (2019, May). Characterization of Fluorescent Extracellular Vesicles Following 5-ALA Use in Patients with Malignant Glioma. Poster presented at: Clinical Research Day 2019, Massachusetts General Hospital, Harvard Medical School; Boston, MA.
  10. Yekula, A., Jones, P.S., Lansbury, E., Small, J.L., Mordecai, S., Hochberg, F.H., Tigges, J., Delcuze, B., Charest, A., Ghiran, I., Balaj, L., Carter, B.S. (2019, April). Characterization of Fluorescent Extracellular Vesicles Following 5-ALA Use in Patients with Malignant Glioma. Poster presented at: International Society of Extracellular Vesicles ISEV Annual Meeting 2019; Kyoto, JPN.

Oral Presentations

  1. Yekula, A., Reddy, V., Haddon, P., Nassiri, N. (2022, April). Direct Stick Embolization (DSE) of a rectal venous malformation via Transanal minimally Invasive Surgery (TAMIS) Oral Presentation presented at: American Society of Colon and Rectal Surgeons Annual Meeting; San Diego, CA.
  2. Yekula, A., Reddy, V., Haddon, P., Nassiri, N. (2022, March). Direct Stick Embolization (DSE) of a rectal venous malformation via transanal minimally Invasive Surgery (TAMIS) Oral Presentation presented at: The International Society for the Study of Vascular Anomalies (ISSVA) World Congress 2022; Vancouver, BC. CAN.
  3. Yekula, A., Fischer, U., Nassiri, N. (2022, March). Covered Endovascular Reconstruction of the Aortic Bifurcation (CERAB) using EVAR components for the treatment of TASC D aortoiliac occlusive disease Oral Presentation presented at: Society of Clinical Vascular Surgery Annual Meeting; Las Vegas, NV.
  4. Yekula, A., Muralidharan, K., Kang, K.M., Small, J.L., Rosh, Z.S., Wang, L., Lau, S., Zhang, H., Lee, H., Bettegowda, C., Chicoine, M.R., Kalkanis, S.N., Shankar, G.M., Nahed, B.V., Curry, W.T., Jones, P.S., Cahill, D.P., Balaj, L., Carter, B.S. (2021, October). TERT Promoter Mutation for Blood-based Diagnosis and Monitoring of Gliomas (Journal of Neuro-Oncology Award) Oral Presentation presented at: Congress of Neurological Sciences Annual Meeting 2021; Austin, TX.
  5. Yekula, A., Kitchen, R., Chakrabortty, S., Carter, B., Breakefield, Xandra., Skog, J., Balaj, L. (2021, July). Liquid Biopsy for Patient Stratification and Monitoring of Dacomitinib Clinical Trial in Patients with EGFR Amplified Recurrent Glioblastoma Oral Presentation presented at: Society of Neurosurgery-Oncology, Basic and Translational Science Conference 2021; Boston, MA.
  6. Yekula, A., Kitchen, R., Chakrabortty, S., Carter, B., Breakefield, Xandra., Skog, J., Balaj, L. (2021, April). Analysis of serum-derived extracellular RNA to monitor treatment response to dacomitinib in adult patients with EGFR amplified recurrent glioblastoma (Finalist) Oral Presentation presented at: Scientific Advisory Committee (SAC) 2021 Annual Meeting, Massachusetts General Hospital, Harvard Medical School; Boston, MA.
  7. Yekula, A. (2021, June). Liquid Biopsy for the Diagnosis and Monitoring of Brain Tumors (Invited Lecture) Oral Presentation presented at: Dandy Neurosurgical Society 2021; New Delhi, IND.
  8. Yekula, A., Wang, L., Muralidharan, K., Small, J., Rosh, Z., Carter, B.S., Balaj, L. (2020, September). Novel Gene Fusions in Glioma Tumor Tissue and Matched Patient Plasma (Best Basic Science Award) Oral Presentation presented at: Congress of Neurological Surgeons CNS 2020 Annual Meeting; Miami, FL
  9. Yekula, A., Muralidharan, K., Carter, B.S., Balaj, L. (2020, July). Dissecting the Heterogeneity of Extracellular Vesicle Sub-populations at Single EV Level. Oral Presentation presented at: Annual Meeting (Virtual), International Society of Extracellular Vesicles ISEV 2020; Philadelphia, PA.
  10. Yekula, A., Chakrabortty, S.K., Kitchen, R.R., Carter, B.S., Breakefield, X.O., Skog, J., Balaj, L. (2020, April). Longitudinal Analysis of Serum-derived Extracellular RNA for Monitoring of Treatment Response to Dacomitinib in Adult Patients with EGFR Amplified Recurrent Glioblastoma. Oral Presentation presented at: Annual Meeting (Virtual), American Association of Neurological Surgeons AANS 2020; Boston, MA.
  11. Yekula, A., Chakrabortty, S.K., Kitchen, R.R., Carter, B.S., Breakefield, X.O., Skog, J., Balaj, L. (2019, December). Longitudinal Analysis of Serum-derived Extracellular RNA for Monitoring of Treatment Response to Dacomitinib in Adult Patients with EGFR Amplified Recurrent Glioblastoma. Oral Presentation presented at: Microvesicle and Exosome Seminar Series MESS, Massachusetts General Hospital, Harvard Medical School; Boston, MA.
  12. Yekula, A., Jones, P.S., Lansbury, E., Small, J.L., Hochberg, F.H., Tigges, J., Delcuze, B., Charest, A., Ghiran, I., Balaj, L., Carter, B.S. (2019, November). Characterization of Fluorescent Extracellular Vesicles following 5-ALA use in Patients with Malignant Glioma. Oral Presentation presented at: Research Program Project Grants (P01) Review Meeting, Massachusetts General Hospital, Harvard Medical School; Boston, MA.
  13. Yekula, A., Jones, P.S., Lansbury, E., Balaj, L., Carter, B.S. (2019, June). Characterization of Fluorescent EVs using Nano-FACS in Patients with Malignant Glioma. Oral Presentation presented at: Annual Meeting, New England Neurosurgical Society NENS 2019; Brewster, MA.
  14. Yekula, A., Jones, P.S., Lansbury, E., Small, J.L., Hochberg, F.H., Tigges, J., Delcuze, B., Charest, A., Ghiran, I., Balaj, L., Carter, B.S. (2019, April). Characterization of Fluorescent Extracellular Vesicles Following 5-ALA Use in Patients with Malignant Glioma. Oral Presentation presented at: Liquid Biopsy Consortium Meeting, National Cancer Institute NCI; Boston, MA.
  15. Yekula, A., Jones, P.S., Lansbury, E., Small, J.L., Hochberg, F.H., Tigges, J., Delcuze, B., Charest, A., Ghiran, I., Balaj, L., Carter, B.S. (2019, April). Characterization of Fluorescent Extracellular Vesicles Following 5-ALA Use in Patients with Malignant Glioma. Oral Presentation presented at: Brain Tumor Research Centre Meeting, Massachusetts General Hospital, Harvard Medical School; Boston, MA.
  16. Yekula, A., & Menard, M. (2018, December). Vascular Implications in Connective Tissue Disorders. Oral Presentation presented at: Vascular Surgery Grand Rounds, Brigham and Woman's Hospital, Harvard Medical School; Boston, MA.
  17. Yekula, A., Arjun, K., Coumans, J.V. (2017, November). Spontaneous Resolution of Syringomyelia in Chiari 1 Malformation. Oral Presentation presented at: Neurosurgery Grand Rounds, Massachusetts General Hospital, Harvard Medical School; Boston, MA.