Davie Freeman, MD, PhD

Resident PGY5, Department of Neurosurgery

Davie Freeman

Contact Info

MD, PhD, Loyola University Chicago Stritch School of Medicine, Chicago, IL

MS, Loyola University Chicago Stritch School of Medicine, Chicago, IL (Neuroscience)

BA, Augustana College, Rock Island. IL (Biology, Art History)

Summary

Dr. Freeman earned his MS in Neuroscience and his MD and PhD from Loyola University Chicago Stritch School of Medicine in Chicago, IL, and his undergraduate degree from Augustana College in Rock Island, IL. While at Loyola, he volunteered at a free clinic on the north side of Chicago that was primarily staffed by medical students. He also participated in a month-long medical mission trip to the Dominican Republic. In addition, Dr. Freeman spent a year as an assistant resident manager at the Ronald McDonald House on the Loyola/Hines VA campus. His thesis-driven master of science project focused on neurogenesis in the adult murine spinal cord following transient ischemia.

Awards & Recognition

  • Michael J. Fox Foundation Rapid Response Award, 2008

Professional Associations

  • American Physician Scientists Association
  • Congress of Neurological Surgeons

Research

Research Summary/Interests

  • Loyola University Health System, IL, worked with Dr. Vikram Prabhu on a clinically oriented research project regarding the decompression of the common peroneal nerve as well as electromyography changes that are present pre and post-op. 08/2012 - 01/2013
  • Loyola University Health System, IL, United States, under Drs. Edward Campbell and Omer Iqbal; helped a faculty and resident team examine some questions about the underlying etiology of keratoconus, a degenerative eye condition. 07/2009 - 06/2013
  • Loyola University Health System, IL, in the laboratory of Dr. Edward Campbell; focus of research was on the protein alpha-synuclein and some of its unique characteristics. Project led to multiple collaborations as well as a paper. It served as the basis for two joint R01 grants and a Michael J. Fox Foundation Rapid Response Award. 07/2006 - 07/2008
  • Loyola University Health System, IL, under Dr. Fletcher White, completed a thesis-driven master of science degree program. Project focused on neurogenesis in the adult murine spinal cord following transient ischemia.

Publications

Publications

  • Freeman D, Cedillos R, Choyke S, Lukic Z, McGuire K, Marvin S, et al. (2013) Alpha-Synuclein Induces Lysosomal Rupture and Cathepsin Dependent Reactive Oxygen Species Following Endocytosis. PLoS ONE 8(4): e62143. doi:10.1371/journal.pone.0062143
  • Iqbal O, Fisher G, Vira S, Syed D, Sadeghi N, Freeman D, Campbell E, Sugar J, Feder R, Fareed J, Bouchard C. Increased Expression of Secreted Frizzled-Related Protein-1 and Microtubule-Associated Protein Light Chain 3 in Keratoconus. Cornea. 2013, May; 32(5): 702-707. Cited in PubMed; PMID: 3449484
  • Sekerkova G, Freeman D, Mugnaini E, Bartles JR. Espin cytoskeletal proteins in the sensory cells of rodent taste buds. Journal of Neurocytology. 2005, Sep; 34(3-5): 171-182. Cited in PubMed; PMID: 16841162

Poster Presentations

  • Flavin, W., Freeman, D., Campbell, E. (2013). The role of Galectin-3 following alpha-synuclein cell invasion in Parkinson’s disease. Presented at: St. Albert's Day Research Symposium; Maywood, IL .
  • Flavin, W., Freeman, D., Campbell, E. (2013). Characterizing the properties and consequences of alpha-synuclein aggregation. Posterresented at: St. Albert's Day Research Symposium; Maywood, IL .
  • Freeman, D., Campbell, E. (2012). Alpha-synuclein induces the rupture of endosomes/lysosomes, leading to the generation of reactive oxygen species in cells. Presented at: Society for Neuroscience; New Orleans, LA .
  • Freeman, D., Campbell, E. (2011). TRIM-2 Interaction with Alpha-Synuclein in an in-vitro Parkinson’s disease model. Presented at: American Physician Scientists Association; Chicago, IL.