Sam Cramer

Chief Resident, Department of Neurosurgery

Sam Cramer

Contact Info

MD, University of Minnesota Medical School

PhD, Neuroscience, University of Minnesota, FENS-IBRO European Neuroscience School, Bertinoro, Italy

BS, University of Wisconsin, Madison

Summary

Dr. Cramer has volunteered a significant number of hours while at the U of M to help mentor fellow neuroscience students as they completed activities such as conducting their own research or participating in the Graduate Program for Neuroscience. He was also a member of the Minnesota Medical Scientist Training Program Admissions Committee and helped organize interview days and reviewed applicants with the committee.

Research is an important focus for Dr. Cramer. He completed an individual postdoctoral research fellowship project in using optogenetics to treat episodic dystonia and has designed and conducted his own research related to neurological conditions such as ataxia and ischemic stroke.

In his spare time, Dr. Cramer enjoys running, biking, reading, fishing and travel.

Awards & Recognition

  • Resident teaching award, Department of Neurosurgery, University of Minnesota
  • Ito Prize Finalist, SRC congress: Cerebellar contribution to brain function, Rome, Italy, 2014
  • Stark Award for Advanced Scholarship, Department of Neuroscience, University of Minnesota, 2014
  • Sping and Yingh Ngoh Lin Award, Department of Neuroscience, University of Minnesota, 2014
  • Milne-Brandenburg Award, Department of Neuroscience, University of Minnesota, 2012
  • Morris Smithberg Memorial Prize for outstanding performance of first year graduate student, Department of Neuroscience, University of Minnesota, 2011

Professional Associations

  • Society for Research on the Cerebellum
  • Society for Neuroscience
  • Society for the Neural Control of Movement

Research

Research Funding Grants

  • Co-Principal Investigator: Minnesota Spinal Cord Injury and Traumatic Brain Injury Research Grant Program, “Wide-field calcium imaging of cortical dysfunction using a distributed head injury model of mild TBI in mice expressing full-length human MAPT”
  • Principal Investigator: Pediatric Device Innovation Consortium Program award, “Instrumented External Ventricular Drain”
  • MnDRIVE Resident/Clinical Fellowship in Neuromodulation. “The effect of deep brain stimulation of central thalamic nuclei on neuronal activity and morphology following cerebral cortical traumatic brain injury using multi-modal optical imaging in mice”
  • Co-Principal Investigator: Minnesota Spinal Cord Injury and Traumatic Brain Injury Research Grant Program: “Cortical Spreading Depolarization After Severe Traumatic Brain Injury”
  • Co-Principal Investigator: Minnesota Spinal Cord Injury and Traumatic Brain Injury Research Grant Program. “Evolution of acute and chronic effects on neuronal activity and morphology following mild cerebral cortical traumatic brain injury using multi-scale optical imaging in mice."

Patents

  • Darrow D, Cramer S, Moen SL, Grande A. Traumatic brain injury catheter. U.S. provisional patent application 16/198,351, May 23, 2019.

Publications

Publications

  • Cramer SW, Carter RE, Aronson JD, Kodandaramaiah SB, Ebner TJ, Chen CC. Through the looking glass: A review of cranial window technology for optical access to the brain. J Neurosci Methods. 2021 Feb 15;354:109100. PMID: 33600850
  • Kaske EA*, Cramer SW*, Pino IP, Do TH, Ladd BM, Sturtevant DT, Ahmadi A, Taha B, Freeman D, Wu JT, Cunningham BA, Hardeman RR, Satin DJ, Darrow DP. Injuries from Less-Lethal Weapons during the George Floyd Protests in Minneapolis. N Engl J Med. 2021 Feb 25;384(8):774-775. PMID: 33440082. (* co-first authors)
  • Cramer SW, McGovern RA, Wang SG, Chen CC, Park MC. Resective epilepsy surgery: assessment of randomized controlled trials. Neurosurg Rev. 2020 Nov 9. PMID: 33169227
  • Cramer SW, Chen CC. Photodynamic Therapy for the Treatment of Glioblastoma. Front Surg. 2020 Jan 21;6(81):1-11. PMID: 022720
  • Ricard JA, Cramer SW, Charles R, Tommee CG, Le A, Bell WR, Chen CC, Flanagan ME. Infratentorial glioblastoma metastasis to bone. World Neurosurgery. 2019. PMID: 31356980
  • Cramer SW, Carter RE, Popa LS, Chen G, Ebner TJ. Abnormal excitability and episodic low frequency oscillations in the cerebral cortex of the tottering mouse. J Neurosci. 2015 Apr 8;35(14):5664-79. PMID: 25855180
  • Armbrust KA, Wang X, Chen G, Cramer SW, Obu T, Rupp-Moody AN, Ebner TJ, Ranum LPW. mGluR1a mislocalization and LTP deficits in a mouse model of spinocerebellar ataxia type 5. Journal of Neuroscience. 2014, Jul; 34(30): 9891-9904. Cited in PubMed; PMID: 25057192. Pub Status: Published.
  • Cramer SW, Baggot C, Cain J, Tilghman J, Allcock B, Miranpuri G, Rajpal S, Sun D, Resnick D. The role of cation-dependent chloride transporters in neuropathic pain following spinal cord injury. Molecular Pain. 2008, Sep; 4(36): 1744-8069. Cited in PubMed; PMID: 18799000. Pub Status: Published.
  • Cramer SW, Carter RE, Popa LS, Chen G, Ebner TJ. Abnormal excitability and episodic low frequency oscillations in the cerebral cortex of the tottering mouse. Journal of Neuroscience. 2015, Apr; 35(14): 5664-5679. Cited in PubMed; PMID: 25855180. Pub Status: Published.
  • Cramer SW, Gao W, Chen G, Ebner TJ. Re-evaluation of the beam and radial hypotheses of parallel fiber action in the cerebellar cortex. Journal of Neuroscience. 2013, Jul; 33(28): 11412-11424. Cited in PubMed; PMID: 23843513. Pub Status: Published.
  • Ebner TJ, Wang X, Gao W, Cramer SW, Chen G. Parasagittal zones in the cerebellar cortex differ in excitability, information processing and synaptic plasticity. Cerebellum. 2012, Jun; 11(2): 418-419. Cited in PubMed; PMID: 22249913. Pub Status: Published.
  • Gulnaz H, Begum G, Kintner DB, Liu Y, Cramer SW, Sun D. DHA inhibits ER Ca2+ release and ER stress in astrocytes following in vitro ischemia. Journal of Neurochemistry. 2012, Feb; 120(4): 622-630. Cited in PubMed; PMID: 22129278. Pub Status: Published.

Peer-reviewed Book Chapter

  • Cramer SW, Li L, and Sun D. (2008). Blood Brain Barrier Dysfunction and the Endothelin System in Cerebral Ischemia. In Jin K and Yang G-Y (Ed.), (pp. 46-51). Oak Park: Bentham Science. Experimental Stroke

Abstracts and Poster Publications

  • Cramer SW, Popa LS, Haley SP, Dhawan S, Carter RE, Ning J, Aronson J, Kodandaramaiah SB, Ebner TJ, Chen CC. Effect of brain tumorigenesis on cerebral cortical functional connectivity in the mouse. Society for NeuroOncology Annual Meeting. Austin, TX, November, 2020.
  • Dominguez J, Nikpasand M, Carter RE, Scott E, Cramer S, Ebner TJ, Kodandaramaiah SB. Engineered transparent polymer skulls for studying local and global effects of repetitive mTBI. Biomedical Engineering. Philadelphia, PA, October, 2019.
  • Carter RE, Scott E, Popa LS, Aronson J, Dominguez J, Ghanbari L, Kodandaramaiah SB, Cramer S, Ebner TJ. Effects of mild traumatic brain injury on widespread cortical function. Society for Neuroscience. Chicago, Il, October, 2019.
  • Ricard JA, Tomee CG, Cramer S, Charles R, Le A, Bell WR, Chen C, Flanagan ME. Intratentorial Glioblastoma Metastasis to Bone. American Association of Neuropathologists. Atlanta GA, June, 2019.
  • Cramer SW, Darrow DP, Bergman TA. Cortical spreading depolarization after severe traumatic brain injury: a feasibility study. Peyton Society Meeting, Minneapolis, MN, July, 2017.
  • Carter RE, Cramer SW, Popa LS, Chen G, Ebner TJ. Abnormal cerebral excitability state in the P/Q-type Ca2+ mutant tottering mouse. Society for Neuroscience. Chicago, Il, October, 2015.
  • Hayes K, Cramer SW, Bellow E, Ebner TJ. Cerebral cortical activity evoked by optogenetic modulation of cerebellar Purkinje cells. University of Minnesota Summer Undergraduate Research Symposium. Minneapolis, MN, August, 2014.
  • Carter RE, Cramer SW, Chen G, Popa LS, Ebner TJ. P/Q-type Ca2+ channelopathy results in low frequency oscillations in the cerebral cortex of the tottering mouse. Society for Neuroscience. Washington DC, November, 2014.
  • Cramer SW, Chen G, Popa LS, Ebner TJ. Low frequency oscillations in the cerebellar and cerebral cortex of the tottering mouse. SRC congress: Cerebellar contribution to brain function. Rome, Italy, July, 2014.
  • Chen, G. Cramer SW, Ranum LPW, Swanson MS, Ebner TJ. Autofluorescence optical imaging of the responses to intracortical stimulation in normal mouse models of myotonic dystrophy. Society for Neuroscience. San Diego, CA, November, 2013.
  • Cramer SW, Chen G, Popa, LS, Ebner TJ. Low frequency oscillations in the cerebral cortex of the tottering mouse. Society for Neuroscience. San Diego, CA, November, 2013.
  • Cramer SW, Gao W, Chen G, Ebner TJ. Re-evaluation of the beam and radial hypotheses of parallel fiber action in the cerebellar cortex. FENS-IBRO School “Causal Neuroscience”. Bertinoro, Italy, June, 2013.
  • Guerrero GG, Cramer SW, Ebner TJ. Optogenetic modulation of episodic dystonia in the mutant tottering mouse. University of Minnesota Undergraduate Research Symposium. Minneapolis, MN, May, 2013.
  • Cramer SW, Gao W, Chen G, Ebner TJ. Cerebellar cortical activation evoked by granule cell input: a re-evaluation of the beam and radial hypotheses. Society for Neuroscience. New Orleans, LA, October, 2012.
  • Cramer SW, Gao W, Chen G, Ebner TJ. Excitatory amino acid transporters regionally sculpt the beam-like response in the cerebellar cortex. The Society for the Neural Control of Movement. Venice, IT, April, 2012.
  • Cramer SW, Gao W, Chen G, Ebner TJ. Excitatory amino acid transporters regionally sculpt the beam-like response in the cerebellar cortex. Graduate Program in Neuroscience Retreat. Minneapolis, MN, February, 2012.
  • Begum G, Kintner D, Liu Y, Cramer S, Sun D. Effects of omega-3 on astrocyte Ca2+ release following in vitro ischemia. Society for Neuroscience. Washington, DC, November, 2011.

Oral Presentations

  • Cramer SW. Low frequency oscillations in a mouse model of P/Q-type Ca2+ channelopathies. Neurology Grand Rounds, Minneapolis, MN. 2014.
  • Cramer SW. Normal and diseased circuitry in the cerebellar and cerebral cortex. Graduate Program in Neuroscience Thesis Defense, Minneapolis, MN. 2014.
  • Cramer SW. Re-evaluation of parallel fiber action in the cerebellar cortex. University of Minnesota MSTP meeting. Minneapolis, MN. February, 2014.
  • Cramer SW. Low frequency oscillations and episodic dystonia in the tottering mouse. Graduate Program in Neuroscience retreat. Minneapolis, MN. 2013.
  • Cramer SW. A patient with an unsteady gait. University of Minnesota MSTP Grand Rounds. Minneapolis, MN. December, 2012.