Sam Cramer

PGY4 Resident, Department of Neurosurgery

Sam Cramer

Contact Info

MD, MD, University of Minnesota Medical School

PhD, Neuroscience, University of Minnesota

BS, University of Wisconsin, Madison

Summary

Dr. Cramer has volunteered a significant number of hours while at the U of M to help mentor fellow neuroscience students as they completed activities such as conducting their own research or participating in the Graduate Program for Neuroscience. He was also a member of the Minnesota Medical Scientist Training Program Admissions Committee and helped organize interview days and reviewed applicants with the committee.

Research is an important focus for Dr. Cramer. He completed an individual postdoctoral research fellowship project in using optogenetics to treat episodic dystonia and has designed and conducted his own research related to neurological conditions such as ataxia and ischemic stroke.

In his spare time, Dr. Cramer enjoys running, biking, reading, fishing and travel.

Awards & Recognition

  • Ito Prize Finalist, SRC congress: Cerebellar contribution to brain function, Rome, Italy, 2014
  • Stark Award for Advanced Scholarship, Department of Neuroscience, University of Minnesota, 2014
  • Sping and Yingh Ngoh Lin Award, Department of Neuroscience, University of Minnesota, 2014
  • Milne-Brandenburg Award, Department of Neuroscience, University of Minnesota, 2012
  • Morris Smithberg Memorial Prize for outstanding performance of first year graduate student, Department of Neuroscience, University of Minnesota, 2011
  • Medical School Year 2 Honors, University of Minnesota, 2010
  • Medical School Year 1 Honors, University of Minnesota, 2009

Professional Associations

  • Society for Research on the Cerebellum
  • Society for Neuroscience
  • Society for the Neural Control of Movement

Research

Publications

Publications

  • Armbrust KA, Wang X, Chen G, Cramer SW, Obu T, Rupp-Moody AN, Ebner TJ, Ranum LPW. mGluR1a mislocalization and LTP deficits in a mouse model of spinocerebellar ataxia type 5. Journal of Neuroscience. 2014, Jul; 34(30): 9891-9904. Cited in PubMed; PMID: 25057192. Pub Status: Published.
  • Cramer SW, Baggot C, Cain J, Tilghman J, Allcock B, Miranpuri G, Rajpal S, Sun D, Resnick D. The role of cation-dependent chloride transporters in neuropathic pain following spinal cord injury. Molecular Pain. 2008, Sep; 4(36): 1744-8069. Cited in PubMed; PMID: 18799000. Pub Status: Published.
  • Cramer SW, Carter RE, Popa LS, Chen G, Ebner TJ. Abnormal excitability and episodic low frequency oscillations in the cerebral cortex of the tottering mouse. Journal of Neuroscience. 2015, Apr; 35(14): 5664-5679. Cited in PubMed; PMID: 25855180. Pub Status: Published.
  • Cramer SW, Gao W, Chen G, Ebner TJ. Re-evaluation of the beam and radial hypotheses of parallel fiber action in the cerebellar cortex. Journal of Neuroscience. 2013, Jul; 33(28): 11412-11424. Cited in PubMed; PMID: 23843513. Pub Status: Published.
  • Ebner TJ, Wang X, Gao W, Cramer SW, Chen G. Parasagittal zones in the cerebellar cortex differ in excitability, information processing and synaptic plasticity. Cerebellum. 2012, Jun; 11(2): 418-419. Cited in PubMed; PMID: 22249913. Pub Status: Published.
  • Gulnaz H, Begum G, Kintner DB, Liu Y, Cramer SW, Sun D. DHA inhibits ER Ca2+ release and ER stress in astrocytes following in vitro ischemia. Journal of Neurochemistry. 2012, Feb; 120(4): 622-630. Cited in PubMed; PMID: 22129278. Pub Status: Published.
  • Luo J, Wang Y, Chen H, Kintner DB, Cramer SW, Gerdts JK, Chen X, Shull GE, Philipson KD, Sun D. A concerted role of Na+-K+-Cl—cotransporter and Na+/Ca2+ exchanger in ischemic damage. Journal of Cerebral Blood Flow and Metabolism. 2008, Apr; 28(4): 737-746. Cited in PubMed; PMID: 17912271. Pub Status: Published.
  • Wang Y, Luo J, Chen X, Chen H, Cramer SW, Sun D. Gene inactivation of Na+/H+ exchanger isoform 1 attenuates apoptosis and mitochondrial damage following transient focal cerebral ischemia. European Journal of Neuroscience. 2008, Jul; 28(1): 51-61. Cited in PubMed; PMID: 18662334. Pub Status: Published.

Peer Reviewed Book Chapter

  • Cramer SW, Li L, and Sun D. (2008). Blood Brain Barrier Dysfunction and the Endothelin System in Cerebral Ischemia. In Jin K and Yang G-Y (Ed.), (pp. 46-51). Oak Park: Bentham Science. Experimental Stroke

Poster Presentationa

  • Begum G, Kintner D, Liu Y, Cramer S, Sun D. (2011). Effects of omega-3 on astrocyte Ca2+ release following in vitro ischemia. Poster presented at: Society for Neuroscience; Washington, DC
  • Carter RE, Cramer SW, Chen G, Popa LS, Ebner TJ. (2014). P/Q-type Ca2+ channelopathy results in low frequency oscillations in the cerebral cortex of the tottering mouse. Poster presented at: Society for Neuroscience; Washington, DC
  • Chen, G. Cramer SW, Ranum LPW, Swanson MS, Ebner TJ. (2013). Autofluorescence optical imaging of the intracortical stimulation in normal mouse models of myotonic dystrophy responses. Poster presented at: Society for Neuroscience; San Diego, CA.
  • Cramer SW, Chen G, Popa LS, Ebner TJ. (2014). Low frequency oscillations in the cerebellar and cerebral cortex of the tottering mouse. Poster presented at: SRC congress: Cerebellar contribution to brain function; Rome, ITA
  • Cramer SW, Chen G, Popa, LS, Ebner TJ. (2013). Low frequency oscillations in the cerebral cortex of the tottering mouse. Poster presented at: Society for Neuroscience; San Diego, CA
  • Cramer SW, Gao W, Chen G, Ebner TJ. (2012). Excitatory amino acid transporters regionally sculpt the beam-like response in the cerebellar cortex. Poster presented at: The Society for the Neural Control of Movement; Venice, ITA
  • Cramer SW, Gao W, Chen G, Ebner TJ. (2012). Cerebellar cortical activation evoked by granule cell input: a re-evaluation of the beam and radial hypotheses. Poster presented at: Society for Neuroscience; New Orleans, LA
  • Cramer SW, Gao W, Chen G, Ebner TJ. (2012). Excitatory amino acid transporters regionally sculpt the beam-like response in the cerebellar cortex. Poster presented at: Graduate Program in Neuroscience Retreat; Minneapolis, MN
  • Cramer SW, Gao W, Chen G, Ebner TJ. (2013). Re-evaluation of the beam and radial hypotheses of parallel fiber action in the cerebellar cortex. Poster presented at: FENS-IBRO School “Causal Neuroscience,” Bertinoro, ITA
  • Guerrero GG, Cramer SW, Ebner TJ. (2013). Optogenetic modulation of episodic dystonia in the mutant tottering mouse. Poster presented at: University of Minnesota Undergraduate Research Symposium; Minneapolis, MN
  • Hayes K, Cramer SW, Bellow E, Ebner TJ. (2014). Cerebral cortical activity evoked by optogenetic modulation of cerebellar Purkinje cells. Poster presented at: University of Minnesota Summer Undergraduate Research Symposium; Minneapolis, MN
  • Kintner DB, Chen X, Cramer S, Luo J, Sun D. (2007). Dysregulation of endoplasmic reticulum calcium in response to oxygen glucose deprivation and reoxygenation: neurons vs. astrocytes. Poster presented at: Society for Neuroscience; San Diego, CA
  • Liu Y, Kintner D, Cramer S, Liu XJ, Sun D. (2008). ER Ca2+ signaling and mitochondrial CYT. C release in astrocytes following in vitro ischemia. Poster presented at: Southeastern Pharmacology Society; Charleston, SC
  • Liu Y, Kintner DB, Cramer SW, Liu XJ, Sun D. (2008). Corresponding release of cytochrome c with intracellular homeostasis in astrocytes following in vitro ischemia. Poster presented at: Society for Neuroscience; Washington, DC
  • Rajpal S, Baggott C, Cain J, Cramer S, Tilghman J, Allcock B, Muranpuri G, Sun D, Resnick D. (2008). The effect of bumetanide administration on thermal hyperalgesia following contusive spinal cord injury in rats. Poster presented at: AANS/CNS Section on Disorders of the Spine and Peripheral Nerves; Orlando, FL.

Oral Presentations

  • Re-evaluation of parallel fiber action in the cerebellar cortex at: University of Minnesota MSTP monthly meeting; Minneapolis, MN, 2014
  • Normal and diseased circuitry in the cerebellar and cerebral cortex presented at: Graduate Program in Neuroscience thesis defense, University of Minnesota; Minneapolis, MN, 2014
  • Oral Low frequency oscillations in a mouse model of P/Q-type Ca2+ channelopathies presented at: Department of Neurology Grand Rounds, University of Minnesota; Minneapolis, MN, 2014
  • Low frequency oscillations and episodic dystonia in the tottering mouse presented at: Graduate Program in Neuroscience retreat; Minneapolis, MN, 2013
  • A patient with an unsteady gait, presented at Grand Rounds; Minneapolis, MN, 2012.