Aja Aravamudhan, PhD

Clinical Chemistry Fellow, Department of Laboratory Medicine and Pathology

Aja Aravamudhan

Contact Info

Postdoctoral Research Fellow, Physiology and Biomedical Science, Mayo Clinic, 2022

PhD, Biomedical Science, University of Connecticut Health Center, 2016

Summary

Research

Publications

Kumbar S.G., Toti U.S., Deng M., James R., Laurencin C.T., Aravamudhan A., Harmon M., Ramos D.M. Novel mechanically competent polysaccharide scaffolds for bone tissue engineering. Biomedical Material, 6, 6, 065005, 2011.

Aravamudhan A., Ramos D.M., Nip J., Subramaniam A., James R., Harmon M., Yu X., Kumbar S. G. Osteoinductive Small Molecules: Growth Factor Alternatives for Bone Tissue Engineering. Current Pharmaceutical Design, 19(19), 3420-8, 2013.

Aravamudhan A., Ramos D.M., Nip J., Harmon M., James R., Deng M., Laurencin C.T., Yu X., Kumbar S.G. Cellulose and Collagen Derived Micro-Nano Structured Scaffolds for Bone Tissue Engineering. J. Biomed. Nanotechnology, 9 (4), 719-731, 2013.

Aravamudhan A., Ramos D.M, Dyment N.A., Rowe D.W., Sanders M.M., Jenkins N., Kumbar S.G. Collagen nanofibril self-assembly on a natural polymeric material for the osteoinduction of stem cells in vitro and biocompatibility in vivo. RSC Advances, 6 (84), 80851-80866, 2016.

Aravamudhan A., Ramos D.M., Nip J., Kalajzic I., Kumbar S.G. Micro‐Nanostructures of Cellulose‐Collagen for Critical Sized Bone Defect Healing. Macromolecular bioscience, 18(2), 1700263,2018.

Manoukian O.S., Lee P., Aravamudhan A., Arul M., Yu X., Kumbar S.G. Spiral Layer-by-Layer Micro- Nanostructured Scaffolds for Bone Tissue Engineering. ACS Biomaterials Science & Engineering, 4(6), 2181-92, 2018.

Ligresti G., Caporarello N., Meridew J.A., Jones D.L., Tan Q., Choi K.M., Haak A.J., Aravamudhan A., Roden A.C., Prakash Y.S., Lomberk G., Urrutia R.A., Tschumperlin D.J. CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis. JCI Insight, 4(12), 10.1172/jci.insight.127111, 2019

Haak A.J., Kostallari E., Sicard D., Ligresti G., Choi K.M., Caporarello N., Jones D.L., Tan Q., Meridew J.A., Espinosa A.M.D., Aravamudhan A., Maiers J.L., Britt R.D., Roden A.C., Pabelick C.M., Prakash Y.S., Nouraie S.M., Li X., Zhang Y., Kass D.K., Lagares D., Tager A.M., Varelas X., Shah V.H., Tschumperlin D.J. Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis. Science translational medicine, 11(516), 10.1126/scitranslmed.aau6296, 2019.

Liu W., Meridew J.A., Aravamudhan A., Ligresti G., Tschumperlin D.J., Tan Q. Targeted regulation of fibroblast state by CRISPR-mediated CEBPA expression, Respiratory Research, 20(1), 1-12, 2019. 10.Aravamudhan A., Haak A.J., Choi K.M., Meridew J.A., Caporarello N., Jones D.L., Tan Q., Ligresti G., Tschumperlin D.J. TBK1 regulates YAP/TAZ and fibrogenic fibroblast activation. AJP Lung cellular and molecular physiology, 318(5), L852-L863, 2020.

Caporarello N., Meridew J.A., Aravamudhan A., Jones D.L., Austin S.A., Pham T.X., Haak A.J., Choi K.M., Tan Q., Haresi A., Huang S.A., Katusic Z.S., Tschumperlin D.J., Ligresti G. Vascular dysfunction in aged mice contributes to persistent lung fibrosis, Aging cell, 19(8), e13196, 2020.

Choi K.M., Haak, A.J., Espinosa A.M.D., Cummins K.A., Link P.A., Aravamudhan A, Wood D.K., Tschumperlin D.J. GPCR-mediated YAP/TAZ inactivation in fibroblasts via EPAC1/2, RAP2C and MAP4K7, JCP, 10.1002/jcp.30459.