Ryan Martinez, MD, PhD

Resident, Department of Laboratory Medicine and Pathology

Ryan Martinez

Contact Info

MD, PhD, Emory University School of Medicine, 2018

BA, Carleton College, 2008

Summary

Ryan is originally from Bend, Oregon. He attended Carleton College for undergraduate and Emory University for medical and graduate school. He chose University of Minnesota residency program for its long history of strong CP training as well as available research opportunities. Outside of work, Ryan enjoys spending time running, biking and skiing, and exploring Minneapolis restaurants and breweries with his wife.

Research

Publications

Wu P, Zhang T, Liu B, Fei P, Cui L, Qin R, Zhu H, Yao D, Martinez RJ, Hu W, An C, Zhang Y, Liu J, Shi J, Fan J, Yin W, Sun J, Zhou C, Zeng X, Xu C, Wang J, Evavold BD, Zhu C, Chen W, Lou J. Mechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition. Mol Cell. 2019 Mar 7;73(5):1015-1027.e7. doi: 10.1016/j.molcel.2018.12.018. Epub 2019 Jan 30. PubMed PMID: 30711376; PubMed Central PMCID: PMC6408234.

DiToro D, Winstead CJ, Pham D, Witte S, Andargachew R, Singer JR, Wilson CG, Zindl CL, Luther RJ, Silberger DJ, Weaver BT, Kolawole EM, Martinez RJ, Turner H, Hatton RD, Moon JJ, Way SS, Evavold BD, Weaver CT. Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells. Science. 2018 Sep 14;361(6407). doi: 10.1126/science.aao2933. PubMed PMID: 30213884; PubMed Central PMCID: PMC6501592.

Andargachew R, Martinez RJ, Kolawole EM, Evavold BD. CD4 T Cell Affinity Diversity Is Equally Maintained during Acute and Chronic Infection. J Immunol. 2018 Jul 1;201(1):19-30. doi: 10.4049/jimmunol.1800295. Epub 2018 May 18. PubMed PMID: 29777029; PubMed Central PMCID: PMC6497530.

Barwick BG, Scharer CD, Martinez RJ, Price MJ, Wein AN, Haines RR, Bally APR, Kohlmeier JE, Boss JM. B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation. Nat Commun. 2018 May 15;9(1):1900. doi: 10.1038/s41467-018-04234-4. PubMed PMID: 29765016; PubMed Central PMCID: PMC5953949.

Bally AP, Tang Y, Lee JT, Barwick BG, Martinez R, Evavold BD, Boss JM2. Conserved Region C Functions To Regulate PD-1 Expression and Subsequent CD8 T Cell Memory. J Immunol. 2017 Jan 1;198(1):205-217. Epub 2016 Nov 28.

Martinez RJ, Andargachew R, Martinez HA, Evavold BD. Low-affinity CD4+ T cells are major responders in the primary immune response. Nat Commun. 2016 Dec 15;7:13848. doi: 10.1038/ncomms13848. PubMed PMID: 27976744; PubMed Central PMCID: PMC5234832.

Martinez RJ, Morris AB, Neeld DK, Evavold BD. Targeted loss of SHP1 in murine thymocytes dampens TCR signaling late in selection. Eur J Immunol. 2016 Sep;46(9):2103-10. doi: 10.1002/eji.201646475. PubMed PMID: 27354309; PubMed Central PMCID: PMC5208044.

Krummey SM, Martinez RJ, Andargachew R, Liu D, Wagener M, Kohlmeier JE, Evavold BD, Larsen CP, Ford ML. Low-Affinity Memory CD8+ T Cells Mediate Robust Heterologous Immunity. J Immunol. 2016 Mar 15;196(6):2838-46. doi: 10.4049/jimmunol.1500639. Epub 2016 Feb 10. PubMed PMID: 26864034; PubMed Central PMCID: PMC4779681.

Martinez RJ, Evavold BD. Lower Affinity T Cells are Critical Components and Active Participants of the Immune Response. Front Immunol. 2015;6:468. doi: 10.3389/fimmu.2015.00468. eCollection 2015. Review. PubMed PMID: 26441973; PubMed Central PMCID: PMC4564719.

Martinez RJ, Neeld DK, Evavold BD. Identification of T cell clones without the need for sequencing. J Immunol Methods. 2015 Sep;424:28-31. doi: 10.1016/j.jim.2015.04.018. Epub 2015 May 8. PubMed PMID: 25960175; PubMed Central PMCID: PMC4560598.

Taylor JJ, Martinez RJ, Titcombe PJ, Barsness LO, Thomas SR, Zhang N, Katzman SD, Jenkins MK, Mueller DL. Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen. J Exp Med. 2012 Oct 22;209(11):2065-77. doi: 10.1084/jem.20112272. Epub 2012 Oct 15. PubMed PMID: 23071255; PubMed Central PMCID: PMC3478923.

Martinez RJ, Zhang N, Thomas SR, Nandiwada SL, Jenkins MK, Binstadt BA, Mueller DL. Arthritogenic self-reactive CD4+ T cells acquire an FR4hiCD73hi anergic state in the presence of Foxp3+ regulatory T cells. J Immunol. 2012 Jan 1;188(1):170-81. doi: 10.4049/jimmunol.1101311. Epub 2011 Nov 28. PubMed PMID: 22124124; PubMed Central PMCID: PMC3244540.