Li Ou, PhD

Assistant Professor, Department of Pediatrics

Li Ou

Contact Info

ouxxx045@umn.edu

Office Phone 612-625-6912

Fax 612-624-2682

Office Address:
Pediatric Genetics and Metabolism
13-122 PWB
516 Delaware St. SE
Minneapolis MN 55455

Mailing Address:
Pediatric Genetics and Metabolism
516 Delaware St. SE MMC 391
Minneapolis MN 55455

Lab Address:
420 Washington Ave SE
5-178 MCB
Minneapolis MN 55455

PhD, Genetics, University of Minnesota, Minneapolis, MN

BS, Biotechnology, Sichuan University, Chengdu, Sichuan, China

Summary

Dr. Li Ou is currently an Assistant Professor in the Department of Pediatrics, University of Minnesota. He received his PhD (major in Genetics, minor in Biostatistics) at the University of Minnesota in 2015. He did a postdoctoral fellowship at the University of Minnesota working with the world-renowned expert in lysosomal diseases, Dr. Chester Whitley. Dr. Ou joined the Department of Pediatrics Faculty as an Assistant Professor in 2019. Dr. Ou’s research focuses on treating lysosomal diseases with gene therapy and gene editing approaches.

Research

Publications

  1. Ou L, DeKelver R, Rhode M, Tom S, Radeke R, St Martin SJ, Santiago Y, Sproul S, Przybilla MJ, Koniar BL, Podetz-Pedersen KM, Laoharawee K, Cooksley RD, Meyer KE, Holmes MC, McIvor RS, Wechsler T, Whitley CB. ZFN-mediated in vivo genome editing corrects murine Hurler syndrome. Mol Ther. 2019 Jan 2;27(1):178-187.
  2. Przybilla MJ, Ou L, Taraban A, Jiang X, Sidhu R, Kell PJ, Ory DS, O'Sullivan MG, Whitley CB. Comprehensive behavioral and biochemical outcomes of novel murine models of GM1-gangliosidosis and Morquio syndrome type B. Mol Genet Metab. 2018 Nov 22. pii: S1096-7192(18)30550-X.
  3. Ou L, Przybilla MJ, Whitley CB. Untargeted metabolomics profiling reveals profound metabolic impairments in mice and patients with Sandhoff disease. Mol Genet Metab. 2018 Sep 14. pii: S1096-7192(18)30437-2.
  4. Ou L, Przybilla MJ, Koniar BL, Whitley CB. SAAMP 2.0: an algorithm to predict genotype-phenotype correlation of lysosomal storage diseases. Clin Genet. 2018 Feb 2. doi: 10.1111/cge.13226.
  5. Ou L, Przybilla MJ, Koniar BL, Whitley CB. RTB lectin-mediated delivery of lysosomal ?-L-iduronidase mitigates disease manifestations systemically including the central nervous system. Mol Genet Metab. 2018 Feb;123(2):105-111.
  6. Laoharawee K, DeKelver R, Podetz-Petersen KM, Rohde M, Sproul S, Nguyen HO, Nguyen T, St Martin S, Ou L, Tom S, Radeke R, Meyer KE, Holmes MC, Whitley CB, Wechsler T, McIvor RS. Dose-dependent IDS expression and prevention of metabolic and neurologic disease in a mouse model of Hunter Syndrome by ZFN-mediated in vivo genome editing. Mol Ther. 2018. 26 (4), 1127-1136.
  7. Schadewald A, Kimball E, Ou L. Coping strategies, stress, and support needs in caregivers of children with mucopolysaccharidosis. JIMD Reports. 2018 Jan 4. doi.org/10.1007/8904_2017_87.
  8. Ou L, Przybilla MJ, Whitley CB. Phenotype prediction for mucopolysaccharidosis type I by in silico analysis. Orphan J Rare Dis. 2017 Jul 4;12(1):125. 
  9. Ou L, Przybilla MJ, Whitley CB. Proteomic analysis of mucopolysaccharidosis I mouse brain with two-dimensional polyacrylamide gel electrophoresis. Mol Genet Metab. 2017 Jan-Feb;120(1-2):101-110.
  10. Ou L, Herzog T, Koniar BL, Gunther R, Whitley CB. High-dose enzyme replacement therapy in murine Hurler syndrome. Mol Genet Metab. 2014 Feb;111(2):116-22.