Ezequiel Marron, PhD

Assistant Professor, Department of Pharmacology,

Ezequiel Marron

Contact Info

marro014@umn.edu

Office Phone 612-626-8480

Office Address:
2-274 Nils Hasselmo Hall
312 Church St SE
Minneapolis, MN 55455

Lab Address:
2-290 Nils Hasselmo Hall
312 Church St SE
Minneapolis, MN 55455

Assistant Professor, Department of Pharmacology


Postdoctoral Visiting Fellow, NIEHS, NIH, Research Triangle Park, NC

PhD, University of Salamanca, Spain, Biology/Neuroscience

MSc.Ed University of Salamanca, Spain, Education

MSc, University of Salamanca, Spain, Neuroscience

BS, University of Salamanca, Spain, Biology and Biochemistry

Summary

Dr. Marron is an Assistant Professor (Academic Track) in the Department of Pharmacology and the Manager of the Viral Vector and Cloning Core at the University of Minnesota. He received a B.S. in Biology and a B.S. in Biochemistry as well as a M.S. degree in Neuroscience, a M.S.Ed in Education from the University of Salamanca Dr. Marron received his PhD in Biology/Neuroscience working in the laboratory of Dr. Raquel E. Rodriguez. After completing postdoctoral training in the laboratory of Dr. David Armstrong at NIEHS–NIH, Dr. Marron joined Dr. Kevin Wickman’s laboratory at the University of Minnesota as a Research Associate. In 2019 Dr. Marron was promoted to Assistant Professor (Academic track) in the Department of Pharmacology at the University of Minnesota.

Expertise

Neurobiology, GPCR signaling, GIRK channels, electrophysiology, Molecular Biology, Viral Tools.

Awards & Recognition

Haseltine Award; Best poster presentation OSSD 2014

Grunenthal Fundation Award; Best Research in Pain 2009

Torres Quevedo Grant; Ministry of Education and Science, Spain 2009

Scholarship Holder F.P.U. (Equivalent to F31); Ministry of Education and Science, Spain 2004

Collaboration Scholarship; Ministry of Education and Science, Spain 2002

Professional Associations

Society for Neuroscience

Society of General Physiologists

Research

Research Summary/Interests

I am interested in understanding the neuroadaptations that occur in the mesocorticolimbic system after drug exposure, and the behavioral expression of such adaptations. Currently, my work focuses on plasticity involving inhibitory signaling regulated by G protein-coupled receptors (GPCRs) and G protein-gated inwardly rectifying potassium (GIRK) channels. Since my early graduate studies which centered on the cloning and characterization of opioid and cannabinoid receptors (as well as endogenous ligands) from the zebrafish (Danio rerio), I have been interested in GPCR-mediated signaling and the effects and modes of action of drugs of abuse, such as opiates. These studies, supervised by Dr. Raquel E. Rodriguez, provided me with a strong background in pharmacology, molecular biology, and cloning. I expanded and refined these skills while working with Dr. Ping-Yee Law at the University of Minnesota (UMN) and during my postdoctoral training with Dr. David Armstrong at NIEHS/NIH. My training with Dr. Armstrong provided me with an excellent opportunity to develop proficiency with techniques in electrophysiology, molecular genetics, and imaging. As a senior postdoctoral researcher in the Wickman lab, I have applied this training to a number of lines of investigation focused on the contribution of GIRK channel to the regulation of cellular excitability in the brain, and related behaviors.

During my tenure at NIEHS/NIH, I utilized AAV and lentiviral vectors to manipulate gene expression in the brain, and to produce stable cell lines as biosensors of GPCR activity. This experience awoke my interest in viral vectors as powerful tools in research and allowed me to train with Drs. Negin Martin and Bernd Gloss in the Viral Vector Core Laboratory at NIEHS/NIH. This training allowed me to generate several custom-made AAV and lentiviral vectors for the Wickman lab, shortly after my arrival in 2013.

More recently, Dr. Kevin Wickman and I established an institutional core facility (the UMN Viral Vector & Cloning Core, or VVCC) that offers custom cloning and viral packaging services to both UMN and external investigators. As Manager of the VVCC, I have developed strong connections with a many of investigators at the University of Minnesota, including those in the field of drug addiction. I have provided guidance to VVCC customers with viral vector design and support related to their grant applications. I take pride and joy in improving the research of investigators at the UMN, and I am fully committed to the continued success of the VVCC as we work to meet the viral and cloning needs of our research community.

Publications