Marilyn Carroll-Santi, PhD

Professor, Department of Psychiatry and Behavioral Sciences

Marilyn Carroll-Santi

Contact Info

mcarroll@umn.edu

Office Phone 612-626-6289

Fax 612-273-9774

Office Address:
Psychiatry
625-C Diehl H
505 Essex St SE
Minneapolis, MN 55455

Mailing Address:
Psychiatry Research
MMC 392 Mayo
8392A (Campus Delivery Code)
420 Delaware St SE
Minneapolis, MN 55455

Administrative Assistant Name
Teneshia Collins

Administrative Email
coll1148@umn.edu

Postdoctoral Fellowship in Behavioral Pharmacology, University of Minnesota

PhD, Psychobiology & Neuroscience, Florida State University

MS, Psychobiology & Neuroscience, Florida State University

BS, Pennsylvania State University

BA, Pennsylvania State University

Summary

I received my BS in Psychology from Pennsylvania State University. I completed my masters, and PhD in Psychobiology and Neuroscience from Florida State University. I further completed my postdoctoral fellowship in Behavioral Pharmacology here at the University of Minnesota.

I am a Professor of Psychology and Neuroscience and my research is focused on factors that underlie drug and food addiction, such as genetic differences, impulsivity, and hormonal influences. As Director of a recent P50 Center grant, I conduct translational research with animal and human subjects on sex differences, stimulant addiction and novel treatments. Currently, I am developing animal models of novel self-initiated and -maintained long-term treatments for addiction with the translational goal of having addicted drug users manage their treatment and recovery over long periods of time. I have over 200 publications, 11,000 citations, and an h-index of 58.

I have been awarded the University of Minnesota President’s and Medical School’s Neuroscience Initiative Award, every year since 2005. I am active in national and local community events including Brain Awareness Week, the Winter Conference on Brain Research Community Outreach and at the Minnesota State Fair’s Neuroscience booth.

Expertise

  • Behavioral Pharmacology 
  •  Biological factors in addiction 
  •  Environmental factors in addiction
  •  Novel behavioral and pharmacological treatment for drug abuse 

Awards & Recognition

University of Minnesota (since 2010)

  • University of Minnesota President’s and Medical School’s Neuroscience Initiative Award, 2005- present

External Sources (since 2010)

  • Election to Fellow, American College of Neuropsychopharmacology, ACNP, 2013
  • Marian Fischman Award, Outstanding Woman Scientist, 2012
  • NIH BRLE CSR Study Section, 2012 - 2016
  • K05, NIDA Senior Scientist Research and Mentorship Award, 2002-2012
  • James C. Smith Distinguished Lectureship, Florida State University, 2011
  • Avant-Garde Award, subcontractor with Dr. Steven Brimijoin, 2010
  • McNair Scholar’s Program Outstanding Service Award, 2010 
  • Professional Associations

    University of Minnesota President’s and Medical School’s Neuroscience Initiative Award, 2005- present

    External Sources

  • Election to Fellow, American College of Neuropsychopharmacology, ACNP, 2013
  • Marian Fischman Award, Outstanding Woman Scientist, 2012
  • NIH BRLE CSR Study Section, 2012 - 2016
  • K05, NIDA Senior Scientist Research and Mentorship Award, 2002-2012
  • James C. Smith Distinguished Lectureship, Florida State University, 2011
  • Avant-Garde Award, subcontractor with Dr. Steven Brimijoin, 2010
  • McNair Scholar’s Program Outstanding Service Award, 2010 
  • Research

    Research Summary/Interests

    The goal of my research is to develop behavioral and pharmacological methods for reducing and preventing drug abuse. In recent work with graduate students and postdocs, we examined the influence of individual differences such as impulsivity, sweet preference, sex/hormonal factors, and genetic factors that maintain drug addiction. A current interest is to understand treatment failure in human drug addicts, as success of treatments is no higher than self-quit methods. Our hypothesis is that treatments fail because craving incubates over long periods after treatment ends. We use self-initiated, self-maintained, long-term treatments, such as physical exercise, to block incubation of craving for weeks to months. We also study another aspect of incubated craving, multiply-triggered-relapse (MTR). After several weeks of forced abstinence we found that in addition to the previously-used drug, multiple cues in the environment (e.g., other drugs of abuse, common drugs such as caffeine and nicotine, and environmental cues) trigger relapse. Incubation of craving and MTR are the targets we are currently studying for treatment development. We are testing self-initiated, long-lasting and self-maintained treatments, such as voluntary exercise and social reward that, alone and/or together, are self-motivated and self-maintained long-term self-treatments for reducing incubation of craving and MTR. We are working with clinical addiction investigators and exercise physiologists to translate these treatment strategies to humans.

    Publications

    Smethells, JR, Greer, A, Dougen, B & Carroll, ME 2020, 'Effects of voluntary exercise and sex on multiply-triggered heroin reinstatement in male and female rats', Psychopharmacology, vol. 237, no. 2, pp. 453-463. https://doi.org/10.1007/s00213-019-05381-2

    Tosun, NL, Allen, SS, Eberly, LE, Yao, M, Stoops, WW, Strickland, JC, Harrison, KA, al Absi, M & Carroll, ME 2018, 'Association of exercise with smoking-related symptomatology, smoking behavior and impulsivity in men and women' Drug and alcohol dependence, vol. 192, pp. 29-37. https://doi.org/10.1016/j.drugalcdep.2018.07.022

    Swalve, N, Smethells, JR, Younk, R, Mitchell, J, Dougen, B & Carroll, ME 2018, 'Sex-specific attenuation of impulsive action by progesterone in a go/no-go task for cocaine in rats' Psychopharmacology, vol. 235, no. 1, pp. 135-143. https://doi.org/10.1007/s00213-017-4750-2

    Carroll, ME & Lynch, WJ 2016, 'How to study sex differences in addiction using animal models' Addiction Biology, vol. 21, no. 5, pp. 1007-1029. https://doi.org/10.1111/adb.12400

    Martinez, LA, Gross, KS, Himmler, BT, Emmitt, NL, Peterson, BM, Zlebnik, NE, Foster Olive, M, Carroll, ME, Meisel, RL & Mermelstein, PG 2016, 'Estradiol facilitation of cocaine Self-Administration in female rats requires activation of mglur5' eNeuro, vol. 3, no. 5, e0140-16.2016. https://doi.org/10.1523/ENEURO.0140-16.2016

    Swalve, N, Smethells, JR & Carroll, ME 2016, 'Progesterone attenuates impulsive action in a Go/No-Go task for sucrose pellets in female and male rats' Hormones and Behavior, vol. 85, pp. 43-47. https://doi.org/10.1016/j.yhbeh.2016.08.001

    Smethells, JR, Swalve, NL, Eberly, LE & Carroll, ME 2016, 'Sex differences in the reduction of impulsive choice (delay discounting) for cocaine in rats with atomoxetine and progesterone' Psychopharmacology, vol. 233, no. 15-16, pp. 2999-3008. https://doi.org/10.1007/s00213-016-4345-3

    Swalve, NL, Smethells, JR & Carroll, ME 2016, 'Sex differences in attenuation of nicotine reinstatement after individual and combined treatments of progesterone and varenicline' Behavioural Brain Research, vol. 308, pp. 46-52. https://doi.org/10.1016/j.bbr.2016.04.023

    Carroll, ME, Collins, M, Kohl, EA, Johnson, S & Dougen, B 2016, 'Sex and menstrual cycle effects on chronic oral cocaine self-administration in rhesus monkeys: Effects of a nondrug alternative reward' Psychopharmacology, vol. 233, no. 15-16, pp. 2973-2984. https://doi.org/10.1007/s00213-016-4343-5

    Smethells, JR, Zlebnik, NE, Miller, DK, Will, MJ, Booth, F & Carroll, ME 2016, 'Cocaine self-administration and reinstatement in female rats selectively bred for high and low voluntary running' Drug and alcohol dependence, vol. 167, pp. 163-168. https://doi.org/10.1016/j.drugalcdep.2016.08.020