Karam Aboudehen, PhD

Assistant Professor of Medicine, Division of Molecular Medicine

Karam Aboudehen

Contact Info

Lab Phone 612-625-0530

Mailing Address:
420 Delaware Street SE
MMC 485 Mayo, 8485 (Campus Delivery Code)
Minneapolis, MN 55455

Lab Address:
Molecular and Cellular Biology Bldg (MCB)
420 Washington Avenue SE
Suite 5-148
Minneapolis, MN 55455-0372

Assistant Professor of Medicine, Division of Molecular Medicine


PhD, Tulane University, New Orleans, LA

Summary

Dr. Karam Aboudehen earned his PhD from Tulane University, and completed his Postdoctoral training at UT southwestern in Peter Igarashi’s laboratory. He is an NIH funded investigator with research focus on studying the role of non-coding RNA in the pathogenesis of polycystic kidney disease (PKD).

Expertise

  • Non-coding RNA biology
  • Genome editing
  • Mouse models of kidney disease
  • Viral gene delivery

Awards & Recognition

  • Mayo clinic pilot and feasibility award grant (2018-2020)
  • UT Southwestern T32 training grant (2012-2014)
  • American Society of Nephrology (2016)
  • Southern Societies for Clinical Investigation (SSCI) award (2009)

Research

Research Summary/Interests

PKD is a debilitating genetic disorder characterized by the accumulation of numerous fluid-filled cysts in the kidneys. The most common form of PKD, autosomal dominant polycystic kidney disease (ADPKD), is primarily caused by mutations in two genes: PKD1 and PKD2. More than 600,000 people in the United States suffer from ADPKD. About half of those affected will progress to end-stage renal failure necessitating dialysis or kidney transplantation. Long noncoding RNAs (lncRNAs) are single-stranded RNA molecules over 200 nucleotides in length and lacking a long open-reading-frame. Recent research has identified a role for lncRNAs as epigenetic regulators of development and disease.

Our group focus on studying lncRNAs that are involved in the pathogenesis of PKD. The long-term goal is to discover therapeutic lncRNAs that prevents or mitigates cyst formation and/or progression in PKD.In addition to our mouse studies, we perform studies in humans with ADPKD to learn how dysregulations in lncRNAs influence the pathogenesis of the disease.

Publications