Bhairab Singh
Assistant Professor, Department of Pediatrics
Contact Info
Assistant Professor, Department of Pediatrics
Faculty, Department of Biomedical Engineering
Member, Stem Cell Institute
Faculty, Masters Program in Stem Cell Biology
Postdoctoral Fellowship in Lillehei Heart Institue, Cardiology Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN
PhD, Cell Biology – Center for Cellular and Molecular Biology, India
MSc, Biotechnology – Jawaharlal Nehru University, India
BSc, Biotechonology – Vinoba Bhave University, India
Assistant Professor, Department of Pediatrics
Summary
Dr. Bhairab Singh is an Assistant Professor in the Department of Pediatrics, Division of Hematology and Oncology at the University of Minnesota. He also serves as faculty (R7) in the Department of Biomedical Engineering (BME). He conducted his Ph.D. studies from the Center for Cellular and Molecular Biology, India in 2009, where he studied the role of small heat shock proteins in stress and differentiation. As a postdoctoral fellow at the Lillehei Heart Institute, Cardiology Division, at the University of Minnesota, Dr. Singh deciphered networks involved in hemato-endothelial lineage decisions during embryonic development. His discoveries also include the identification of novel pathways in the promotion of mammalian heart regeneration. Dr. Singh joined the Department of Pediatrics Faculty as an Assistant Professor in 2019.
Expertise
Cardiovascular Development and Regeneration,
Stem cell technologies,
Mouse Genetics,
In vitro Chimera analysis
Cell and Molecular Biology
Awards & Recognition
2019 Recipient, Top Basic Science Abstract Award, AHA 2016 Recipient, Dr. Marvin and Hadassah Bacaner Basic Science Research Award 2016 Recipient, Best Scientist Award in Cardiovascular Sciences 2013 Recipient, Best Post-Doctoral Award in Cardiovascular Sciences 2009 Recipient, NIMTLI Fellowship 2008 Recipient, Senior Research Fellowship 2007 Recipient, Dr. Amjad Rahi Award 2006 Recipient, Junior Research Fellowship 2003 Recipient, Department of Biotechnology Fellowship 2002 Recipient, Summer Fellowship at Panacea Biotech Ltd.
Research
Research Summary/Interests
My work primarily focuses on understanding the pathways/factors that promote cardiac regeneration and repair. The long-term goal of my research is to identify factors and pathways that govern progenitor cell differentiation, proliferation, and maintenance. My laboratory is highly interested in deciphering the networks involved in the promotion of regeneration of the adult mammalian heart following injury. We have made several seminal discoveries including; Etv2-miR-130a-Pdgfra cascade in the divergence of hemato-endothelial lineages (Cell Reports; 2015), evolutionary conserved HH-Gli1-Mycn network in cardiomyocyte proliferation and regeneration (Nature Communication; 2018). Research projects in my laboratory is focused on the identifications of novel pathways in human heart development and ways to modulate the injury response in humanized models.
Research Funding Grants
2019-2021 Regenerative Medicine Minnesota, Role: Principal Investigator
Patents
Regulation of Mesodermal Specification
DJ Garry, N Koyano-Nakagawa, MG Garry, B Singh - US Patent App. 15/748,772, 2019
Methods to Enhance Myocardial Regeneration and/or Repair
DJ Garry, MG Garry, B Singh - US Patent App. 16/519,889, 2020