Bhairab Singh

Assistant Professor, Department of Pediatrics

Bhairab Singh

Contact Info

bnsingh@umn.edu

Office Phone 612-624-5948

Office Address:
Nils Hasselmo Hall
7-136

Mailing Address:
312 Church St SE,
Nils Hasselmo Hall
7-136,
Minneapolis, MN 55455

Lab Address:
312 Church St SE,
Nils Hasselmo Hall
7-258,
Minneapolis, MN 55455

Assistant Professor, Department of Pediatrics

Faculty, Department of Biomedical Engineering

Member, Stem Cell Institute

Faculty, Masters Program in Stem Cell Biology


Postdoctoral Fellowship in Lillehei Heart Institue, Cardiology Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN

PhD, Cell Biology – Center for Cellular and Molecular Biology, India

MSc, Biotechnology – Jawaharlal Nehru University, India

BSc, Biotechonology – Vinoba Bhave University, India


Assistant Professor, Department of Pediatrics

Summary

Dr. Bhairab Singh is an Assistant Professor in the Department of Pediatrics, Division of Hematology and Oncology at the University of Minnesota. He also serves as faculty (R7) in the Department of Biomedical Engineering (BME). He conducted his Ph.D. studies from the Center for Cellular and Molecular Biology, India in 2009, where he studied the role of small heat shock proteins in stress and differentiation. As a postdoctoral fellow at the Lillehei Heart Institute, Cardiology Division, at the University of Minnesota, Dr. Singh deciphered networks involved in hemato-endothelial lineage decisions during embryonic development. His discoveries also include the identification of novel pathways in the promotion of mammalian heart regeneration. Dr. Singh joined the Department of Pediatrics Faculty as an Assistant Professor in 2019.

Expertise

Cardiovascular Development and Regeneration,

Stem cell technologies,

Mouse Genetics,

In vitro Chimera analysis

Cell and Molecular Biology

Awards & Recognition

2019 Recipient, Top Basic Science Abstract Award, AHA

2016 Recipient, Dr. Marvin and Hadassah Bacaner Basic Science Research Award

2016 Recipient, Best Scientist Award in Cardiovascular Sciences

2013 Recipient, Best Post-Doctoral Award in Cardiovascular Sciences

2009 Recipient, NIMTLI Fellowship

2008 Recipient, Senior Research Fellowship

2007 Recipient, Dr. Amjad Rahi Award

2006 Recipient, Junior Research Fellowship

2003 Recipient, Department of Biotechnology Fellowship

2002 Recipient, Summer Fellowship at Panacea Biotech Ltd.

Research

Research Summary/Interests

My work primarily focuses on understanding the pathways/factors that promote cardiac regeneration and repair. The long-term goal of my research is to identify factors and pathways that govern progenitor cell differentiation, proliferation, and maintenance. My laboratory is highly interested in deciphering the networks involved in the promotion of regeneration of the adult mammalian heart following injury. We have made several seminal discoveries including; Etv2-miR-130a-Pdgfra cascade in the divergence of hemato-endothelial lineages (Cell Reports; 2015), evolutionary conserved HH-Gli1-Mycn network in cardiomyocyte proliferation and regeneration (Nature Communication; 2018). Research projects in my laboratory is focused on the identifications of novel pathways in human heart development and ways to modulate the injury response in humanized models.

Research Funding Grants

2019-2021 Regenerative Medicine Minnesota, Role: Principal Investigator

Patents

Regulation of Mesodermal Specification

DJ Garry, N Koyano-Nakagawa, MG Garry, B Singh - US Patent App. 15/748,772, 2019

Methods to Enhance Myocardial Regeneration and/or Repair

DJ Garry, MG Garry, B Singh - US Patent App. 16/519,889, 2020

Publications