George J. Trachte, PhD

Natriuretic peptides and their influences on the nervous system with emphasis on interactions with the sympathetic nervous system and hearing.

See full list of publications at: PubMed

1. Trachte, G.J and Fitzakerley, JL: Natriuretic peptides modulate inner ear functions. Submitted to Physiological Genomics 2017

2. Hinz, M, Stein, A Trachte, G.J. and Uncini, T: Neurotransmitter testing: a comprehensive. Neurophychiatr Dis Treat: 2010 (2): 177-183, 2010

3. Trachte G.J., Uncini T., and Hinz M.: Both stimulatory and inhibitory effects of dietary 5-hydroxytryptophan and tyrosine are found on urinary excretion of serotonin and dopamine in a large human population. Neuropsychiatr Dis Treat 5:227-35 (Epub 2009 May 20)

4. Trachte, G.J., Neuronal Regulation and Function of Natriuretic Peptide Receptor C. Peptides 26: 1060-1067, 2005.

5. Trachte, G.J.: Natriuretic peptides suppress protein kinase C activity to reduce evoked dopamine efflux from Pheochromocytoma (PC12) cells. Endocrinology 144: 94-100, 2003.

6. Trachte, G.J.: Natriurectic peptide clearance receptors are critical regulators of sympathetic neurotransmission. Recent Res Devel. Endocrinol 2:173-182, 2001

7. Trachte, G.J.: Signal-transducing activity of natriuretic peptide C receptor (NPR-C) in neural tissue. pp. 436-444 In "Pharmacology and Therapeutics in the new millennium" ed. By SK Gupta, Narosa Publishing House, New Delhi, India, 2001

8. Trachte, G.J.: Urodilatin attenuates sympathetic neurotransmission in the rabbit isolated vas deferens without activating guanylyl cyclase. Life Sciences69: 2833-2844, 2001.

9. Trachte, G.J.: Depletion of natriuretic peptide C receptors eliminates inhibitory effects of C-type natriuretic peptide on evoked neurotransmitter efflux. J. Pharmacol. Exp. Ther.294: 210-215, 2000.

10. Kanwal, S., D.G. Lowe and G.J. Trachte: Intracellular fragments of the natriuretic peptide receptor-C (NPR-C) attenuate dopamine efflux. Endocrinology140: 1118-1124, 1999.

11. Takida, S., B.J. Elmquist and G.J. Trachte: C-type natriruetic peptide attenuates evoked dopamine efflux by influencing GoalphaHypertension33: 124-129, 1999.

12. Takida, S and Trachte G.J.: Signal transducing role of clearance receptors as exemplified by the natriuretic peptide C receptor. Current Topics in Pharamcology 4: 97-106, 1998

13. Trachte, G.J.: "Physiology of the clearance receptor" in "Contemporary Endocrinology: natriuretic peptides in health and disease" pp. 259-274 ed. by WK Samson and ER Levin Humana Press Inc, Totowa, NJ 1997

14. Kanwal, S., B.J. Elmquist and G.J. Trachte: Atrial natriuretic peptide inhibits evoked catecholamine release by altering sensitivity to calcium. J. Pharmacol. Exp. Ther.283: 426-433, 1997.

15. Trachte, G.J., S. Kanwal, B.J. Elmquist and R.J. Ziegler: C-type natriuretic peptide neuromodulates via "clearance" receptors. Amer. J. Physiol., 268: C978-C984, 1995.

16. Trachte, G.J. and J.G. Drewett: C-type natriuretic peptide neuromodulates independently of guanylyl cyclase activation. Hypertension23: 38-43, 1994.

17. Kanwal, S. and G.J. Trachte: Potassium channel inhibitors attenuate neuromodulatory effects of atrial natriuretic factor in the rabbit isolated vas deferens. J. Pharmacol. Exp. Ther.268: 117-123, 1994.

18. Trachte, G.J.: Atrial natriuretic factor (ANF) alters neurotransmission independently of Guanylate cyclase-coupled receptors in the rabbit vas deferens. J. Pharmacol. Exp. Ther.264: 1227-1233, 1993.

19. Drewett, J.G., R.J. Ziegler and G.J. Trachte: Neuromodulatory effects of atrial natriuretic peptides correlate with an inhibition of adenylate cyclase but not an activation of guanylate cyclase. J. Pharmacol. Exp. Ther.260: 689-696, 1992.

20. Johnson, B.G., G.J. Trachte and J.G. Drewett: Neuromodulatory effect of the atrial natriuretic factor clearance receptor binding peptide, C-ANF(4-23)-NH2 in rabbit isolated vasa deferentia. J. Pharmacol. Exp. Ther.257:720-726, 1991.

21. Waters, D.J., D.D. Caywood, G.J. Trachte, R.T. Turner and S.F. Hodgson. The effect of aspirin on bone mass and bone prostaglandin E in canine immobilization (disuse) osteoporosis. Acta Orthopaedica Scandinavica 62:238-243, 1991.

22. Fitzgerald, T.J., M.A. Tomai, G.J. Trachte and T. Rice: Prostaglandins in experimental syphilis: treponemes stimulate adherent spleen cells to secrete prostaglandin E2, and indomethacin upregulates immune functions. Infection and Immunity 59:143-149, 1991.

23. Odean, M.J., G.J. Trachte and A.G. Johnson. Characterization of immune suppression induced by polyribonucleotides. Int. J. Immunopharmacology13:339-348, 1991.

24. Trachte, G.J., C.M. Ferrario and M.C. Khosla: Selective blockade of angiotensin responses in the rabbit isolated vas deferens by angiotensin receptor antagonists. J. Pharmacol. Exp. Ther.255:929-934, 1990.

25. Drewett, J.G., R.J. Ziegler and G.J. Trachte. Neuromodulatory effects of ANF are independent of guanylate cyclase in adrenergic, neuronal pheochromocytoma cells. J. Pharmacol. Exp. Ther.255:497-503, 1990.

26. Trachte, G.J.: Pharmacological differentiation of angiotensin effects in the rabbit isolated vas deferens with dithiothreitol and pertussis toxin. J. Pharmacol. Exp. Ther.253:80-84, 1990.

27. Trachte, G.J. and L.J. Heller: Adenosine receptor antagonism attenuates angiotensin II effects on adrenergic neurotransmission in the rabbit isolated vas deferens. J. Pharmacol. Exp. Ther.253:490-496, 1990.

28. Trachte, G.J., K. Meixner, C.M. Ferrario and M.C. Khosla: Prostaglandin production in response to angiotensin-(1-7) in rabbit isolated vas deferens. Prostaglandins39:385-394, 1990.

29. Stein, E. and G.J. Trachte. Thromboxane mimetics enhance adrenergic neurotransmission in the rabbit isolated portal vein. J. Cardiovasc. Pharmacol.14:469-474, 1989.

30. Heller, L.J., G.J. Trachte and J.F. Regal. Role of adenosine in hypoxic alterations of anaphylaxis of isolated guinea pig hearts. Amer. J. Physiol. 257:H1378-1388, 1989.

31. Drewett, J.G., R.J. Ziegler, G.R. Marchand and G.J. Trachte. Cyclic guanosine 3',5' monophosphate mediates the inhibitory effect of atrial natriuretic factor in adrenergic, neuronal pheochromocytoma cells. J. Pharmacol. Exp. Ther.250:428-432, 1989.

32. Trachte, G.J. and E. A. Stein. Thromboxane receptor agonists enhance adrenergic neurotransmission in rabbit isolated mesenteric arteries. J. Pharmacol. Exp. Ther.249:216-220, 1989.

33. Drewett, J.G., G.R. Marchand and G.J. Trachte. Atrial natriuretic factor inhibits adrenergic neurotransmission in rabbit isolated portal veins. American Society of Hypertension Symposium Series, Vol. 3, Advances in Atrial Peptide Research, p. 342-351, 1989.

34. Drewett, J.G., G.J. Trachte and G.R. Marchand. Atrial natriuretic factor inhibits adrenergic and purinergic neurotransmission in the rabbit isolated vas deferens. J. Pharmacol. Exp. Ther.248:135-142, 1989.

35. Trachte, G.J., S.B. Binder and M.J. Peach. Indirect evidence for separate vesicular neuronal origins of norepinephrine and ATP in the rabbit vas deferens. Eur. J. Pharmacol.164:425-433, 1989.

36. Trachte, G.J. Angiotensin effects on vas deferens adrenergic and purinergic neurotransmission. Eur. J. Pharmacol.146:261-269, 1988.

37. Trachte, G.J., P.J. Hook, J.R. Kemp, E.P. Acosta, and R.J. Ziegler. Thromboxane synthesis and actions in isolated adrenergic nerve (PC12) cells. J. Pharmacol. Exp. Ther.247:43-46, 1988.32. Trachte, G.J. Adrenergic nerves mediate angiotensin-induced prostaglandin release in the rabbit vas deferens. J. Pharmacol. Exp. Ther.246:211-217, 1988.

38. Drewett, J.G., G.R. Marchand, R.J. Ziegler and G.J. Trachte. Atrial natriuretic factor inhibits norepinephrine release from an adrenergic clonal cell line (PC12). Eur. J. Pharmacol.150:175-179, 1988.

39. Trachte, G.J. Prostaglandins do not mediate the inhibitory effects of angiotensins II and III on autonomic neurotransmission in the rabbit vas deferens. Prostaglandins36:215-228, 1988.

40. Trachte, G.J. and E. Stein. Platelet-generated thromboxane A2 enhances norepinephrine release from adrenergic nerves. J. Pharmacol. Exp. Ther. 247:1139-1145, 1988

41. Trachte, G.J., E. Stein, and M.J. Peach. Alpha adrenergic receptors mediate angiotensin-induced prostaglandin production in the rabbit isolated vas deferens. J. Pharmacol. and Exp. Ther.240:433-440, 1987.

42. Trachte, G.J. Adrenergic receptors mediating force and prostaglandin production in the rabbit vas deferens. Prostaglandins 33:25-35, 1987.

43. Trachte, G.J. Prostacyclin mediates arachidonic acid-induced relaxation of rabbit isolated mesenteric arteries. J. Cardiovasc. Pharmacol.8:758-764, 1986.

44. Trachte, G.J. A thromboxane agonist (U46619) potentiates norepinephrine efflux from adrenergic nerves. J. Pharmacol. and Exp. Ther.237:473-477, 1986.

45. Saye, J., S.B. Binder, G.J. Trachte and M.J. Peach. Angiotensin peptides and PGE2 synthesis: modulation of neurogenic responses in the rabbit vas deferens. Endocrinology119:1895-1903, 1986

46. Trachte, G.J. The influence of prostaglandins on neurotransmission in the rabbit isolated vas deferens. Prostaglandins29:47-60, 1985.

47. Baker, K.M., C.P. Campanile, G.J. Trachte and M.J. Peach. Identification and characterization of the rabbit angiotensin II myocardial receptor. Circ. Res.54:286-295, 1984.

48. Trachte, G.J., E.J. Sybertz, M. Michener, S. Bruce Binder and M.J. Peach. angiotensin III induced modulation of neurogenic responses in the rabbit vas deferens and portal vein. Naunyn Schmiedebergs Arch. Pharmacol. 326:327-333, 1984.

49. Trachte, G.J. and M.J. Peach. Temperature effects on octa- and hepta-peptide angiotensins. Proc. Soc. Exp. Biol. Med.177:47-54, 1984.

50. Trachte, G.J. and M.J. Peach. A potent nonequilibrium angiotensin II antagonist induces only competitive inhibition of angiotensin III responses. J. Cardiovasc. Pharmacol.5:1025-1033, 1983.

51. Trachte, G.J., J.A. Ackerly and M.J. Peach. Inotropic cardiac and vascular actions of (Ala7) angiotensin analogs. J. Cardiovascular Pharmacol.3:138-146, 1981.

52. Trachte, G.J. and A.M. Lefer. Prostaglandin-mediated vasoconstriction in isolated cat arteries. Blood Vessels 17:196-201, 1980.48. Feinberg, G., G.J. Trachte, M. Curtis, and A.M. Lefer. Dietary modification of the vascular effect of prostacyclin in hypertensive rats. Prostaglandins and Med.5:235-242, 1980.

53. Trachte, G.J. and A.M. Lefer. Shock potentiating actions of angiotensin II infusion in cats. Circ. Shock7:343-351, 1980.

54. Trachte, G.J. and A.M. Lefer. Effect of angiotensin II receptor blockade by (Sar1, Ala8) angiotensin II (saralasin) in hemorrhagic shock. Amer. J. Physiol.236:H280-H285, 1979.

55. Lefer, A.M., G.J. Trachte, J.B. Smith, W.E. Barnette, and K.C. Nicalaou. Circulatory and platelet actions of 6,9-thio-prostacyclin (PGI2-S) in the cat. Life Sci.25:259-264, 1979.

56. Trachte, G.J., and A.M. Lefer. Mechanism of the protective action of the converting enzyme inhibitor (SQ 14,225) in hemorrhagic shock. Proc. Soc. Exp. Biol. Med.162:54-57, 1979.

57. Trachte, G.J. and A.M. Lefer. Inotropic and vasoactive effects of the naturally occurring angiotensins in isolated cat cardiac muscle and coronary arteries. Res. Comm. Chem. Pathol. Pharmacol.25:419-427, 1979.

58. Trachte, G.J., A.M. Lefer, D. Aharony, and J.B. Smith. Potent constriction of cat coronary arteries by hydroperoxides of arachidonic acid and its blockade by anti-inflammatory agents. Prostaglandins19:909-914, 1979.

59. Trachte, G.J., and A.M. Lefer. Salutary effects of dexamethasone in hemorrhagic shock. Arch. Internat. Pharmacodyn. Therap.232:309-320, 1978.

60. Trachte, G.J., and A.M. Lefer. Beneficial action of a new angiotensin converting enzyme inhibitor (SQ 14,225) in hemorrhagic shock in cats. Circ. Res.43:577-582, 1978.

61. Trachte, G.J., and A.M. Lefer. Influence of dopamine on liver dynamics in hemorrhagic shock. Circ. Shock4:305-317, 1977.