Christopher Staley, PhD
Assistant Professor, Department of Surgery
Contact Info
Assistant Professor, Department of Surgery
Assistant Professor, Microbiology, Immunology and Cancer Biology (MICaB) Ph.D. Graduate Program
Assistant Professor, Bioinformatics and Computational Biology Graduate Program (BICB)
Faculty, Microbiology, Immunology and Cancer Biology (MICaB) Ph.D. Graduate Program
PhD, Environmental and Ecological Microbiology, University of South Florida, 2012
BS, Microbiology, University of South Florida, 2007
Post-doctoral Researcher, Minnesota Mississippi Metagenome Project. PI: Michael Sadowsky; Biotechnology Institute, University of Minnesota, 2012-2014
Research Associate, Microbiome and Fecal Microbiota Transplantation. PIs: Alex Khoruts and Michael Sadowsky; Microbiota Therapeutics Program, University of Minnesota, 2014–2017.
Summary
The intestinal microbiota is a vital organ critical to the development, functioning, and health of the human the host. Our research focus is to characterize how disruptions in this community affect the onset and progression of diseases and conditions e.g., obesity, colorectal cancer, and inflammatory bowel diseases. By applying microbial ecology principles and leveraging next-generation sequencing technologies, our goal is to develop targeted, microbiota-based therapies to improve patient outcomes.
Expertise
- Microbiology
- Microbial ecology
- Computational biology
- Biostatistics
Awards & Recognition
Professional Associations
Research
Research Summary/Interests
- Microbial community dynamics related to obesity and type 2 diabetes
- Fecal microbiota transplantation therapies
- Patterns of dysbiosis related to health outcomes
- Network modeling of microbial communities
- Personalized microbiota therapeutics
- Microbiota interactions in solid and non-solid cancers
Publications
- Vaughn, B.P. Kaiser, T.,Staley, C., Hamilton, M.J., Reich, J., Craiziger, C., Kabage, A., Sadowsky, M.J., Khoruts, A. 2018. Fecal bile acid and microbiota profiles in inflammatory bowel disease and primary sclerosing cholangitis. Clin. Exp. Gastroenerol. 12, 9-19. doi:10.2147/CEG.S186097
- Webster, A.D.,Staley, C., Hamilton, M.J., Huang, M., Fryxell, K., Erickson, R., Sadowsky, M.J., Khoruts, A. 2018. Short-term changes in dietary sulfur content fail to alter the relative abundances of intestinal sulfate-reducing bacteria. Gut Microbes.in press
- Rashidi, A., Kaiser, T., Holtan, S., Weisdorf, D., Khoruts, A.,Staley, C.2018. Pre-transplant recovery of microbiome diversity without recovery of the original microbiome. Bone Marrow Transplantation.in press. doi:10.1038/s41409-018-0414-z
- Staley, C., Kaiser, T., Khoruts, A. 2018. Clinician guide to microbiome testing. Dig. Dis. Sci. 63(12), 3167-3177. doi:10.1007/s10620-018-5299-6
- Staley, C., Kaiser, T., Vaughn, B.P., Graiziger, C.T., Hamilton, M.J., Khoruts, A., Sadowsky, M.J., 2017. Predicting recurrence ofClostridium difficileinfection following encapsulated fecal microbiota transplantation. Microbiome 6, 166. doi:10.1186/s40168-018-0549-6
- Jahansouz, C.,Staley, C., Kizy, S., Xu, H., Hertzel, A., Corryell, J., Singroy, S., Hamilton, M., DuRand, M., Bernlohr, D., Sadowsky, M., Khoruts, A., Ikramuddin, S., 2018 Antibiotic-induced disruption of intestinal microbiota contributes to failure of vertical sleeve gastrectomy. Ann. Surg. in press. doi:10.1097/SLA.
0000000000002729 - Smillie, C.S., Sauk, J., Gevers, D., Friedman, J., Sung, J., Youngster, I., Hohmann, E.L., Staley, C., Khoruts, A., Sadowsky, M.J., Allegretti, J.R., Smith, M.B., Xavier, R.J., Alm, E.J. 2018. Strain tracking reveals the determinants of bacterial engraftment in the human gut following fecal microbiota transplantation. Cell Host Microbe. 23: 229-240. doi:10.1016/j.chom.2018.01.003
- Staley, C., Khoruts, A., Sadowsky, M.J. 2017. Contemporary applications of fecal microbiota transplantation to treat intestinal diseases in humans. Arch. Med. Res.48(8), 766-773.doi:10.1016/j.arcmed.2017.11.
006 PMID: 29183720 - Staley, C., Kaiser, T., Beura, L.K., Hamilton, M.J., Weingarden, A.R., Bobr, A., Kang, J., Masopust, D., Sadowsky, M.J., Khoruts, A., 2017. Stable engraftment of human microbiota into mice with a single oral gavage following antibiotic conditioning. Microbiome 5, 87. doi:10.1186/s40168-017-0306-2
- Staley, C., Vaugh, B.P., Graiziger, C.T., Singroy, S., Hamilton, M.J., Yao, D., Chen, C., Khoruts, A., Sadowsky, M.J., 2017. Community dynamics drive punctuated engraftment of the fecal microbiome following transplantation using freeze-dried, encapsulated fecal microbiota. Gut Microbes 8(3), 276-288. doi:http://dx.doi.org/10.1080/19490976.2017.1299310
- Staley, C., Hamilton, M.J., Vaughn, B.P., Graiziger, C.T., Newman, K.M., Kabage, A.J., Sadowsky, M.J., Khoruts, A., 2017. Successful resolution of recurrent Clostridium difficile infection using freeze-dried, encapsulated microbiota. Am. J. Gastroenterol. 112(6), 940-947 doi:doi: 10.1038/ajg.2017.6
- Jahansouz, C., Staley, C., Bernlohr, D.A., Sadowsky, M.J., Khoruts, A., Ikramuddin, S., 2017. Sleeve gastrectomy drives persistent shifts in the gut microbiome. Surg. Obes. Relat. Dis. 13(6), 916-924. doi:10.1016/j.soard.2017.01.003
- Sadowsky, M.J., Staley, C., Heiner, C., Hall, R., Kelly, C.R., Brandt, L., Khoruts, A., 2017. Analysis of gut microbiota – an ever changing landscape. Gut Microbes 8(3), 268-275. doi:10.1080/19490976.2016.1277313
- Staley, C., Weingarden, A.R., Khoruts, A., Sadowsky, M.J., 2017. Interaction of gut microbiota with bile acid metabolism and its influence on disease states. Appl. Microbiol. Biotechnol. 101, 47–64. doi:10.1007/s00253-016-8006-6
- Staley, C., Vaughn, B.P., Graiziger, C.T., Sadowsky, M.J., Khoruts, A., 2017. Gut-sparing treatment of urinary tract infection in patients at high risk of Clostridium difficile infection. J. Antimicrob. Chemother. 72, 522–528. doi:10.1093/jac/dkw499
- Staley, C., Kelly, C.R., Brandt, L.J., Khoruts, A., Sadowsky, M.J., 2016. Complete microbiota engraftment is not essential for recovery from recurrent Clostridium difficile infection following fecal microbiota transplantation. MBio 7, e01965-16. doi:10.1128/MBIO.01965-16
- Kelly, C., Khoruts, A., Staley, C., Sadowsky, M., Abd, M., Alani, M., Bakow, B., Curran, P., McKenney, J., Tisch, A., Reinert, S., Machan, J., Brandt, L., 2016. Fecal microbiota transplant prevents recurrence in multiply recurrent C. difficile. Ann. Intern. Med. 165, 609–616. doi:doi:10.7326/M16-0271