Luca Schifanella, MD, PhD

Assistant Professor, Surgical Outcomes and Precision Medicine Research Division, Department of Surgery

Luca Schifanella

Contact Info

schif184@umn.edu

Administrative Assistant Name
Ngoc (Natalie) Ha, MPH

Administrative Phone
612-301-8604

Administrative Email
ngoch@umn.edu

Assistant Professor, Surgical Outcomes and Precision Medicine Research Division, Department of Surgery


M.D., Medicine and Surgery. Università degli Studi di Milano, (University of Milan), Milan, Italy - University of Zaragoza, Faculty of Medicine, Zaragoza, Spain

Ph.D., Clinical and Experimental Medicine. Università degli Studi di Milano, (University of Milan), Milan, Italy in collaboration with the Graduate Partnership Program (GPP) of the Office of Intramural Training and

Education (OITE) of the National Institutes of Health (NIH), Bethesda, Maryland, US.

Summary

Dr. Schifanella completed his Medical Degree at the University of Milan, in the Department of Infectious and Tropical Diseases of the Luigi Sacco Hospital Medical School. Dr. Schifanella enrolled in a Graduate Partnership Program (GPP) and received his PhD in Clinical and Experimental Medicine from the NIH-GPP and the University of Milan, Italy. This multicenter program emphasizes communication and collaboration skills, integration of information, and interdisciplinary investigation. He currently serves as an assistant professor in the newly established Division of Outcomes and Precision Medicine Research (DOPMR) of the Department of Surgery. The mission of the DOPMR is to perform innovative interdisciplinary translational research on the mechanisms by which the microbiome impacts human health and implement potential interventions to improve health. The research goals of the DOPMR include tailoring personalized medical and surgical interventions that can improve predicted-, patient-specific- outcomes.

Research

Research Summary/Interests

Infectious and Tropical Diseases

Immunology

Experimental Design

Publications

Schifanella L† J.L. Anderson†, M. Galli, M. Corbellino, A. Lai, G. Wieking, B. Grzywacz, N.R. Klatt, A.T. Haase and T.W. Schacker. Massive viral replication and cytopathic effects in focal COVID-19 pneumonia point to potential benefits of early antiviral treatment. †These authors contributed equally to this work.- Nat Med, submitted

Gorini G, Fourati S, Vaccari M, Gordon SN, Brown DR, Law GL , Jean Chang J, Richard Green R, Fredrik Barrena?s F, Liyanage NPM, Doster MN, Schifanella L, Bissa M, de Castro IS, Parks RW, Galli V, Fuller DH, Santra S, Agy M, Pal R, Palermo RE, Tomaras GD, Shen X, LaBranche CC, Montefiori DC, Venzon DJ, Trinh HV, Rao M, Gale, Jr. M, Sekaly RP,Genoveffa Franchini G. Engagement of monocytes, NK cells, and CD4+ Th1 cells by ALVAC-SIV vaccination results in a decreased risk of SIVmac251 vaginal acquisition. PLOS Pathogens 2020 February 3, In Press.

Silva de Castro I, Gordon SN, Liu J, Bissa M, McKinnon K, Trinh HV, Doster MN, Schifanella L, Liyanage NP, Cao J, Cheng O, Foulds K, Roederer M, Koup RA, Shen X, Tomaras GD, Venzon DJ, Forthal DN, Fouts T, Montefiori DC, Tartaglia J, Rao M, Ostrowski M, Franchini G, Vaccari M.- ALVAC-HIV B/C candidate HIV vaccine efficacy dependent on neutralization profile of challenge virus and adjuvant dose and type J Virol 2020 Jan 2. doi: 10.1128/JVI.01933-19.

Schifanella L, Barnet S, Bissa M, Galli V, Doster M, Vaccari M, Tomaras G, Shen X, Phogat S, Pal R, Montefiori DC, LaBranche. CC, Rao M, Trinh HV, Washington-Parks R, Liyanage N, Brown D, Liang F, Lore K, Venzon D, Magnanelli W, Metrinko M, Kramer J, Breed M, Alter G, Ruprecht R and Franchini G- ALVAC-HIV B/C candidate HIV vaccine efficacy dependent on neutralization profile of challenge virus and adjuvant dose and type PLOS Pathogens 2019 December 3, doi: 10.1371/journal.ppat.1008121

Isabela Silva de Castro, Shari Gordon, Jun Liu, Massimiliano Bissa, Katherine McKinnon, Hung Trinh, Melvin Doster, Luca Schifanella, Namal Liyanage, JinChao Cao, Olivia Cheng, Kathryn Foulds, Mario Roederer, Richard Koup, Xiaoying Shen, Georgia Tomaras, David Venzon, Donald Forthal, Timothy Fouts, David Montefiori, Jim Tartaglia, Mangala Rao, Mario Ostrowski, Genoveffa Franchini, and Monica Vaccari - Expression of CD40L by the ALVAC-SIV vector abrogates T cell responses in macaques. Journal of Virology, 2019, December, in press

Gorini G, Fourati S, Vaccari M, Gordon S, Brown D, Law L, Namal P. Liyanage N, Doster MN, Schifanella L, Bissa M, Silva de Castro I, Washington-Parks R, Galli V, Fuller DH, Santra S, Agy M, Ranjit Pal , Robert E. Palermo R, Georgia D. Tomaras G, Xiaoying Shen X, LaBranche CC, Montefiori DC, Venzon DJ, Rao M, Trinh HV, Gale M, Sekaly RP and Franchini G - Engagement of monocytes, NK cells, and CD4+ Th1 cells by ALVAC-SIV vaccination results in a decreased risk of SIVmac251 vaginal acquisition PLOS Pathogens 2019 September, submitted

Vaccari M, Fourati S, Brown D, Silva de Castro I, Bissa M, Schifanella L, Doster M, Foulds K, Roederer M, Koup R, Sui Y, Berzofsky J, Sekaly RP and Franchini G.- Myeloid Cell Crosstalk Regulates the Efficacy of the DNA/ALVAC/gp120 HIV Vaccine Candidate - Frontiers in Immunology 2019 May 14. doi: 10.3389/fimmu.2019.01072