Araki Lab

Takako Araki, MD - Principal Investigator

The Araki Lab aims to understand the physiology and pathophysiology of pituitary tumors. In particular, we study the mechanism of gender-biased occurrences of Cushing’s disease. Cushing's disease is significantly more common in females, with a ratio of 1:4-6, and more exaggerated with the specific gene mutation of USP8 (1:8-20). This is the highest gender bias in all non-gonadal diseases. Our goal is to discover novel gender specific personalized Cushing's disease tumor therapy, and to develop a novel mechanism and concept for gender biased diseases. Our lab is also conducting a clinical/molecular study of pituitary physiology in post-COVID infection and other types of pituitary tumors.