Resuscitation Clinical Research
Resuscitation science is a developing sub-specialty of Interventional Cardiology under the leadership of Demetri Yannopoulos, MD. The focus of this center is to conduct research that focuses on all aspects of resuscitation from sudden cardiac arrest. This center will conduct research to answer critical questions about new treatments, innovative medical devices, and strategies for patient management that spans from bystander response, pre-hospital providers, and in-hospital care. The clinical research team includes partnerships with the Lillihei Clinical Research Unit, and the Center for Biometric Research supported by National Center for Advancing Translational Sciences of the National Institutes of Health Award Number UL1TR000114.
Basic Science Laboratory
The laboratory focuses on understanding the mechanisms of cell death that occur during cardiac arrest while also testing various treatment strategies to prevent damage and increase the likelihood of functional recovery. The lab, at the University of Minnesota, is one of the most advanced models to study sudden cardiac death in the nation. Our studies span the fields of biochemistry, molecular biology, cell biology, biomedical engineering, physiology, and medicine. The assembled team is an interdisciplinary group of investigators that are focused on the development of studies that ensure results that can be translated in to patient care models. The expansion of knowledge acquisition will continue to rise from the studies conducted, as a wide spectrum of expertise and capital investment is in place. The team looks forward to continued discoveries and innovative solutions to the problem of sudden cardiac death.
The University of Minnesota and Center for Resuscitation Medicine have led several important research initiatives that are dedicated to the development, evaluation, and advancement of novel, lifesaving protocols and technologies. One of the results of this work is that the Twin Cities became the first large metropolitan area with a unified cardiac catheterization laboratory access protocol for patients who experience out-of-hospital cardiac arrest. Partners are also working to develop effective therapies for sudden cardiac arrest. They are testing promising new medications that could protect the heart and brain from cardiac arrest and resuscitation-related injuries. The future holds the potential for a clinical study on a life support therapy that could improve cardio-cerebral outcomes in patients who do not receive bystander CPR and experience prolonged untreated cardiac arrest.
“A strategic approach to implementation of resuscitation science discoveries and new therapies is required to foster evidence adoption, use, and sustainability. Once a new treatment has demonstrated benefit in controlled clinical trials, it must be tested in increasingly realistic settings to confirm effectiveness and to identify the optimal clinical practice protocols. Translational research focuses on the translation of new findings in basic science into new treatments and the adoption of those treatments in practice (Rubio et al., 2010). In the resuscitation field, guidelines are a predominant mechanism for translating research into practice. The rapid translation of basic research findings into new treatments and the adoption of new treatments into practice is more likely if clinical trials and related studies are designed to produce results that can facilitate evidence-based practice.”