Obesity and cardiovascular disease are among the leading causes of morbidity and mortality worldwide. Our research focuses on the interplay between intermediary metabolism and these disease processes.
The Dudley laboratory is a translational physiology laboratory that focuses on mechanisms, novel diagnostics, and innovative cures for arrhythmias and heart failure with preserved ejection fraction.
Dan’s laboratory has a long-standing interest in regenerative and stem cell biology with a focus on the heart and skeletal muscle. In their studies of the heart and skeletal muscle, the Garry laboratory utilizes an array of technologies including gene disruption strategies, transgenesis, single cell genome analysis, gene editing (TALEN and CRISPR technologies), inducible ES/EB model systems, hiPSC technologies, FACS and other cellular, biochemical and molecular biological techniques.
In my laboratory, we study the role of primary afferent neurons in the control of cardiovascular responses to exercise. We are interested in the basic mechanisms that drive the exercise pressor reflex (EPR) under normal, physiological conditions but we also have a great deal of interest in the control of the EPR in disease.
ES cells are totipotent and capable of recapitulating all of the developmental events of embryogenesis. They are therefore theoretically the ideal source of cells for regenerative therapies.
Our main research interest involves investigating tumor heterogeneity and intercellular communication in a spectrum of invasive and aggressive solid tumor malignancies. Projects in our lab focus on investigating the biology of cancer cells as they relate to cancer cell invasion, progression, tumor recurrence, and chemotherapy resistance. We invite you to learn more about our work and our research team.
Research Projects in vitro gene transfer muscle structure-function in vivo cardiac gene transfer transgenic animals experimental cardiac gene therapy animal models of heart disease Heart function in vivo gene-environment exercise stress.
The focus of the O-Uchi laboratory is to understand the detailed mechanism underlying cardiac excitation and contraction/metabolism coupling by Ca2+ ion in the physiological and pathological conditions.
Our laboratory has a long-term interest in understanding the molecular mechanisms controlling lineage-specific differentiation of pluripotent stem cells (i.e. embryonic and adult reprogrammed stem cells), and applying this information to efficiently generate tissue-specific stem/progenitor cells endowed with in vivo regenerative potential.
The Prins lab will work to define the molecular mechanisms that underlie right ventricular (RV) failure in pulmonary arterial hypertension (PAH). Although rare, PAH is a devastating disease with a median survival of only 5 years after diagnosis.
The Sachs Lab's goal is to identify molecular mechanisms of leukemia stem cell self-renewal in acute myeloid leukemia (AML). Self-renewal is a feature of leukemia stem cells that allow them to recapitulate leukemia and cause relapse.
The van Berlo lab works to uncover the biological pathways that regulate cardiac regeneration. Over the past decade it has become clear that the heart contains a small fraction of cells, called stem cells or progenitor cells, which are undifferentiated and retain the capacity to become cardiomyocytes.