Adam Z. Cheng

Adam Cheng


Entering Class:

Washington University
Biology and Mathematics majors, Anthropology minor
B.A, 2012

University of Minnesota
Microbiology, Immunology and Cancer Biology Graduate Program
Ph.D., 2019

MSTP Student Governance:

  • Student Advisory Committee 2013-2015
  • Student Admissions Committee 2014-2016, 2017-18

Honors and Awards:

  • Beatrice Z. Milne and Theodore Brandenburg Award, 2019
  • Vaccines Travel Award, 2019
  • Wilfred Wetzel Graduate Fellowship, 2019
  • MICaB Outstanding Graduate Student Award, 2019
  • Ruth L. Kirschstein National Research Service Award for Predoctoral MD/PhD Fellows, National Cancer Institute, 2015-2020
  • MICaB Golden Pipetman Award, 2017
  • Center for Genome Engineering Travel Grant, 2018
  • Graduate School Excellence Research Grant, 2018

Thesis Advisor: Reuben Harris, Ph.D.


Thesis Research

A conserved mechanism of APOBEC counteraction by herpesvirus ribonucleotide reductases.

Publications (pubmed)

Cheng AZ, Moraes SN, Attarian C, Yockteng-Melgar J, Jarvis MC, Biolatti M, Galitska G, Dell'Oste V, Frappier L, Bierle CJ, Rice SA, Harris RS. A Conserved Mechanism of APOBEC3 Relocalization by Herpesviral Ribonucleotide Reductase Large Subunits. J Virol. 2019 Nov 13;93(23). pii: e01539-19.

Cheng AZ, Yockteng-Melgar J, Jarvis MC, Malik-Soni N, Borozan I, Carpenter MA, McCann JL, Ebrahimi D, Shaban NM, Marcon E, Greenblatt J, Brown WL, Frappier L, Harris RS. Epstein-Barr virus BORF2 inhibits cellular APOBEC3B to preserve viral genome integrity. Nat Microbiol. 2019 Jan;4(1):78-88. PMCID: PMC6294688

Ebrahimi D, Richards CM, Carpenter MA, Wang J, Ikeda T, Becker JT, Cheng AZ, McCann JL, Shaban NM, Salamango DJ, Starrett GJ, Lingappa JR, Yong J, Brown WL, Harris RS. Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease. Nat Commun. 2018 Oct 8;9(1):4137. PMCID: PMC6175962

Salamango DJ, Becker JT, McCann JL, Cheng AZ, Demir Ö, Amaro RE, Brown WL, Shaban NM, Harris RS. APOBEC3H Subcellular Localization Determinants Define Zipcode for Targeting HIV-1 for Restriction. Mol Cell Biol. 2018 Nov 13;38(23). pii: e00356-18. PMCID: PMC6234287

Hayward JA, Tachedjian M, Cui J, Cheng AZ, Johnson A, Baker ML, Harris RS, Wang LF, Tachedjian G. Differential Evolution of Antiretroviral Restriction Factors in Pteropid Bats as Revealed by APOBEC3 Gene Complexity. Mol Biol Evol. 2018 Jul 1;35(7):1626-1637. PMCID: PMC5995163.

Dong X, Cheng A, Zou Z, Yang YS, Sumpter RM Jr, Huang CL, Bhagat G, Virgin HW, Lira SA, Levine B. Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):2994-9. PMCID: PMC4801257


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