Anja M. Touma

Honors and Awards:

• Ruth L. Kirschstein National Research Service Award for Predoctoral MD/PhD Fellows, National Heart, Lung, and Blood Institute, 2019-2023

Thesis Advisor: Sivaraj Sivaramakrishnan, Ph.D.

Publications (pubmed)

Touma AM, Malik RU, Gupte T, Sivaramakrishnan S. Allosteric modulation of adenosine A1 and cannabinoid 1 receptor signaling by G-peptides. Pharmacol Res Perspect. 2020 Dec;8(6):e00673. PMCID: PMC7596666

Sandhu M, Touma AM, Dysthe M, Sadler F, Sivaramakrishnan S, Vaidehi N. Conformational plasticity of the intracellular cavity of GPCR-G-protein complexes leads to G-protein promiscuity and selectivity. Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11956-11965. PMCID: PMC6575595

For work prior to the MSTP

Swenson AM, Tang W, Blair CA, Fetrow CM, Unrath WC, Previs MJ, Campbell KS, Yengo CM. Omecamtiv Mecarbil Enhances the Duty Ratio of Human β-Cardiac Myosin Resulting in Increased Calcium Sensitivity and Slowed Force Development in Cardiac Muscle. J Biol Chem. 2017 Mar 3;292(9):3768-3778. PMCID: PMC5339759

Trivedi DV, Muretta JM, Swenson AM, Davis JP, Thomas DD, Yengo CM. Direct measurements of the coordination of lever arm swing and the catalytic cycle in myosin V. Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14593-8. PMCID: PMC4664342

Swenson AM, Trivedi DV, Rauscher AA, Wang Y, Takagi Y, Palmer BM, Málnási-Csizmadia A, Debold EP, Yengo CM. Magnesium modulates actin binding and ADP release in myosin motors. J Biol Chem. 2014 Aug 22;289(34):23977-91. PMCID: PMC4156094

Trivedi DV, Muretta JM, Swenson AM, Thomas DD, Yengo CM. Magnesium impacts myosin V motor activity by altering key conformational changes in the mechanochemical cycle. Biochemistry. 2013 Jul 9;52(27):4710-22. PMCID: PMC3855573