Anja M. Touma

Email: touma@umn.edu
Entering Class:Â 2015
Education:
Gustavus Adolphus College
Biochemistry and Molecular Biology major
B.A., 2012
University of Minnesota
Biochemistry, Molecular Biology and Biophysics
Ph.D., 2021
MSTP Student Governance:
- Student Advisory Committee, 2015-2017
Honors and Awards:
- Ruth L. Kirschstein National Research Service Award for Predoctoral MD/PhD Fellows, National Heart, Lung, and Blood Institute, 2019-2023
Thesis Advisor:Â Sivaraj Sivaramakrishnan, Ph.D.
Publications (pubmed)
Touma AM, Tang W, Rasicci DV, Vang D, Rai A, Previs SB, Warshaw DM, Yengo CM, Sivaramakrishnan S. Nanosurfer assay dissects β-cardiac myosin and cardiac myosin-binding protein C interactions. Biophys J. 2022 May 18:S0006-3495(22)00406-4.
Touma AM, Nijjar PS, Manousakis GE, Kamdar F. A rare case report of severe cardiomyopathy associated with myotonic dystrophy type 2. Eur Heart J Case Rep. 2022 Feb 8;6(3):ytac015. PMCID: PMC894210
Touma AM, Malik RU, Gupte T, Sivaramakrishnan S. Allosteric modulation of adenosine A1 and cannabinoid 1 receptor signaling by G-peptides. Pharmacol Res Perspect. 2020 Dec;8(6):e00673. PMCID: PMC7596666
Sandhu M, Touma AM, Dysthe M, Sadler F, Sivaramakrishnan S, Vaidehi N. Conformational plasticity of the intracellular cavity of GPCR-G-protein complexes leads to G-protein promiscuity and selectivity. Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11956-11965. PMCID: PMC6575595
For work prior to the MSTP
Swenson AM, Tang W, Blair CA, Fetrow CM, Unrath WC, Previs MJ, Campbell KS, Yengo CM. Omecamtiv Mecarbil Enhances the Duty Ratio of Human β-Cardiac Myosin Resulting in Increased Calcium Sensitivity and Slowed Force Development in Cardiac Muscle. J Biol Chem. 2017 Mar 3;292(9):3768-3778. PMCID: PMC5339759
Trivedi DV, Muretta JM, Swenson AM, Davis JP, Thomas DD, Yengo CM. Direct measurements of the coordination of lever arm swing and the catalytic cycle in myosin V. Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14593-8. PMCID: PMC4664342
Swenson AM, Trivedi DV, Rauscher AA, Wang Y, Takagi Y, Palmer BM, Málnási-Csizmadia A, Debold EP, Yengo CM. Magnesium modulates actin binding and ADP release in myosin motors. J Biol Chem. 2014 Aug 22;289(34):23977-91. PMCID: PMC4156094
Trivedi DV, Muretta JM, Swenson AM, Thomas DD, Yengo CM. Magnesium impacts myosin V motor activity by altering key conformational changes in the mechanochemical cycle. Biochemistry. 2013 Jul 9;52(27):4710-22. PMCID: PMC3855573