David B. Stagg

Thesis Research

The role of hepatocyte D-hydroxybutyrate dehydrogenase in ketone body metabolism and liver health.

Publications (pubmed)

Nelson AB, Chow LS, Stagg DB, Gillingham JR, Evans MD, Pan M, Hughey CC, Myers CL, Han X, Crawford PA, Puchalska P. Acute aerobic exercise reveals FAHFAs distinguish the metabolomes of overweight and normal weight runners. JCI Insight. 2022 Feb 22:e158037. Online ahead of print.

Stagg DB, Gillingham JR, Nelson AB, Lengfeld JE, André d'Avignon D, Puchalska P, Crawford PA. Diminished ketone interconversion, hepatic TCA cycle flux, and glucose production in D-β-hydroxybutyrate dehydrogenase hepatocyte-deficient mice. Mol Metab. 2021 Nov;53:101269. PMCID: PMC8259407

Puchalska P, Nelson AB, Stagg DB, Crawford PA. Determination of ketone bodies in biological samples via rapid UPLC-MS/MS. Talanta. 2021 Apr 1;225:122048.

Work prior to the UMN MSTP: 

Stagg DB, Whittlesey RL, Li X, Lozovatsky L, Gardenghi S, Rivella S, Finberg KE. Genetic loss of Tmprss6 alters terminal erythroid differentiation in a mouse model of β-thalassemia intermedia. Haematologica. 2019 Oct;104(10):e442-e446. PMCID: PMC6886429

Norris JD, Ellison SJ, Baker JG, Stagg DB, Wardell SE, Park S, Alley HM, Baldi RM, Yllanes A, Andreano KJ, Stice JP, Lawrence SA, Eisner JR, Price DK, Moore WR, Figg WD, McDonnell DP. Androgen receptor antagonism drives cytochrome P450 17A1 inhibitor efficacy in prostate cancer. J Clin Invest. 2017 Jun 1;127(6):2326-2338. PMCID: PMC5451248

Pollock JA, Wardell SE, Parent AA, Stagg DB, Ellison SJ, Alley HM, Chao CA, Lawrence SA, Stice JP, Spasojevic I, Baker JG, Kim SH, McDonnell DP, Katzenellenbogen JA, Norris JD. Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer. Nat Chem Biol. 2016 Oct;12(10):795-801. PMCID: PMC5030124

Gustafson JL, Neklesa TK, Cox CS, Roth AG, Buckley DL, Tae HS, Sundberg TB, Stagg DB, Hines J, McDonnell DP, Norris JD, Crews CM. Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging. Angew Chem Int Ed Engl. 2015 Aug 10;54(33):9659-62. PMCID: PMC4547777