Elise R. Breed

Honors and Awards:

• Ruth L. Kirschstein National Research Service Award for Predoctoral MD/PhD Fellows, National Institute of Allergy and Infectious Disease, 2017-2021

MSTP Student Governance:

• Student Advisory Committee 2015-2017
• Student Admissions Committee 2015-2018

Thesis Advisor: Kristin Hogquist, Ph.D.

Thesis Research

Negative selection of T cells in the thymus.

Publications (pubmed)

Wang H, Breed ER, Lee YJ, Qian LJ, Jameson SC, Hogquist KA. Myeloid cells activate iNKT cells to produce IL-4 in the thymic medulla. Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22262-22268.

Martinov T, Swanson LA, Breed ER, Tucker CG, Dwyer AJ, Johnson JK, Mitchell JS, Sahli NL, Wilson JC, Singh LM, Hogquist KA, Spanier JA, Fife BT. Programmed Death-1 Restrains the Germinal Center in Type 1 Diabetes. J Immunol. 2019 Aug 15;203(4):844-852.

Breed ER, Watanabe M, Hogquist KA. Measuring Thymic Clonal Deletion at the Population Level. J Immunol. 2019 Jun 1;202(11):3226-3233.

Steinert EM, Thompson EA, Beura LK, Adam OA, Mitchell JS, Guo M, Breed ER, Sjaastad FV, Vezys V, Masopust D. Cutting Edge: Evidence for Nonvascular Route of Visceral Organ Immunosurveillance by T Cells. J Immunol. 2018 Jul 15;201(2):337-342. PMCID: PMC6039241

Meier LA, Auger JL, Engelson BJ, Cowan HM, Breed ER, Gonzalez-Torres MI, Boyer JD, Verma M, Marath A, Binstadt BA. CD301b/MGL2+ Mononuclear Phagocytes Orchestrate Autoimmune Cardiac Valve Inflammation and Fibrosis. Circulation. 2018 Jun 5;137(23):2478-2493. PMCID: PMC5988921

Breed ER, Lee ST, Hogquist KA. Directing T cell fate: How thymic antigen presenting cells coordinate thymocyte selection. Semin Cell Dev Biol. 2018 Dec;84:2-10. Review.

Schuldt NJ, Auger JL, Spanier JA, Martinov T, Breed ER, Fife BT, Hogquist KA, Binstadt BA. Cutting Edge: Dual TCRα Expression Poses an Autoimmune Hazard by Limiting Regulatory T Cell Generation. J Immunol. 2017 Jul 1;199(1):33-38. Epub 2017 May 24.

Breed ER, Binstadt BA. Autoimmune valvular carditis. Curr Allergy Asthma Rep. 2015 Jan;15(1):491. Review. PMCID: PMC4440872

For work prior to entering the U of MN MSTP:

Breed ER, Hilliard CA, Yoseph B, Mittal R, Liang Z, Chen CW, Burd EM, Brewster LP, Hansen LM, Gleason RL Jr, Pandita TK, Ford ML, Hunt CR, Coopersmith CM. The small heat shock protein HSPB1 protects mice from sepsis. Sci Rep. 2018 Aug 21;8(1):12493. PMCID: PMC6104051

Liang Z, Xie Y, Dominguez JA, Breed ER, Yoseph BP, Burd EM, Farris AB, Davidson NO, Coopersmith CM. Intestine-specific deletion of microsomal triglyceride transfer protein increases mortality in aged mice. PLoS One. 2014 Jul 10;9(7):e101828. PMCID: PMC4092051

Mittal R, Wagener M, Breed ER, Liang Z, Yoseph BP, Burd EM, Farris AB 3rd, Coopersmith CM, Ford ML. Phenotypic T cell exhaustion in a murine model of bacterial infection in the setting of pre-existing malignancy. PLoS One. 2014 May 5;9(5):e93523. PMCID: PMC4010417

Hunter RA, Privett BJ, Henley WH, Breed ER, Liang Z, Mittal R, Yoseph BP, McDunn JE, Burd EM, Coopersmith CM, Ramsey JM, Schoenfisch MH. Microfluidic amperometric sensor for analysis of nitric oxide in whole blood. Anal Chem. 2013 Jun 18;85(12):6066-72. PMCID: PMC3712765

Jung E, Perrone EE, Liang Z, Breed ER, Dominguez JA, Clark AT, Fox AC, Dunne WM, Burd EM, Farris AB, Hotchkiss RS, Coopersmith CM. Cecal ligation and puncture followed by methicillin-resistant Staphylococcus aureus pneumonia increases mortality in mice and blunts production of local and systemic cytokines. Shock. 2012 Jan;37(1):85-94. PMCID: PMC3241900

Fox AC, Breed ER, Liang Z, Clark AT, Zee-Cheng BR, Chang KC, Dominguez JA, Jung E, Dunne WM, Burd EM, Farris AB, Linehan DC, Coopersmith CM. Prevention of lymphocyte apoptosis in septic mice with cancer increases mortality. J Immunol. 2011 Aug 15;187(4):1950-6. PMCID: PMC3150286