Germán L. Vélez Reyes

Germán Vélez Reyes


Entering Class:


University of Puerto Rico, Rio Piedras
Interdisciplinary Studies in Natural Sciences major, Political Science minor 
B.S., 2011

University of Minnesota
Microbiology, Immunology and Cancer Biology Graduate Program
Ph.D., 2019

MSTP Student Governance:

  • Student Advisory Committee 2014-2016

Thesis Advisor: David Largaespada, Ph.D.

Thesis Research

A multi-organ approach to the role of RSPO2 in carcinogenesis.

Publications (pubmed)

Vélez-Reyes GL, Koes N, Ryu JH, Kaufmann G, Berner M, Weg MT, Wolf NK, Rathe SK, Ratner N, Moriarity BS, Largaespada DA. Transposon Mutagenesis-Guided CRISPR/Cas9 Screening Strongly Implicates Dysregulation of Hippo/YAP Signaling in Malignant Peripheral Nerve Sheath Tumor Development. Cancers (Basel). 2021 Mar 30;13(7):1584. PMCID: PMC8038069

Conboy CB, Vélez-Reyes GL, Rathe SK, Abrahante JE, Temiz NA, Burns MB, Harris RS, Starr TK, Largaespada DA. R-Spondins 2 and 3 Are Overexpressed in a Subset of Human Colon and Breast Cancers. DNA Cell Biol. 2021 Jan;40(1):70-79.

Conboy CB, Vélez-Reyes GL, Tschida BR, Hu H, Kaufmann G, Koes N, Keller B, Alsinet C, Cornellà H, Pinyol R, Abrahante JE, Temiz NA, Linden MA, Amin K, Kuka TP, Keng VW, Llovet JM, Starr TK, Largaespada DA. R-spondin 2 Drives Liver Tumor Development in a Yes-Associated Protein-Dependent Manner. Hepatol Commun. 2019 Sep 3;3(11):1496-1509. PMCID: PMC6824083

For work prior to entering the U of MN MSTP:

Rivera-Peña B, Ruíz-Fullana FJ, Vélez-Reyes GL, Rodriguez-Benitez RJ, Marcos-Martínez MJ, Trinidad-Pinedo J, Báez A. HPV-16 infection modifies overall survival of Puerto Rican HNSCC patients. Infect Agent Cancer. 2016 Aug 24;11(1):47. PMCID: PMC4995614

Danahay H, Pessotti AD, Coote J, Montgomery BE, Xia D, Wilson A, Yang H, Wang Z, Bevan L, Thomas C, Petit S, London A, LeMotte P, Doelemeyer A, Vélez-Reyes GL, Bernasconi P, Fryer CJ, Edwards M, Capodieci P, Chen A, Hild M, Jaffe AB. Notch2 is required for inflammatory cytokine-driven goblet cell metaplasia in the lung. Cell Rep. 2015 Jan 13;10(2):239-52.