Ian N. Cheong
Entering Class: 2011
University of California, San Diego
University of Minnesota
Neuroscience Graduate Program
MSTP Student Governance:
- Student Advisory Committee 2014-2016
Thesis Advisor: Gulin Oz, Ph.D.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that is characterized by rapidly progressive deterioration of motor neurons. Currently there is no effective treatment, and clinical trials of therapeutic candidates have been hampered by a lack of robust biomarkers for monitoring disease progression. Magnetic resonance spectroscopy (MRS) shows promise as a noninvasive method of brain metabolite profiling. Recent improvements in MRS technology and higher magnetic fields have increased the variety of metabolites that we can reliably detect and quantify. Our aim is to use ultra-high field MRS to establish the neurochemical profile of the ALS disease state. This will provide clues to understanding the pathophysiology of ALS as well as identify potential biomarkers that correlate with clinical measures of disease severity and progression.
Cheong I, Deelchand DK, Eberly LE, Marjańska M, Manousakis G, Guliani G, Walk D, Öz G. Neurochemical correlates of functional decline in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2019 Mar;90(3):294-301. PMCID: PMC 6467050
Cheong I, Marjańska M, Deelchand DK, Eberly LE, Walk D, Öz G. Erratum to: Ultra-High Field Proton MR Spectroscopy in Early-Stage Amyotrophic Lateral Sclerosis. Neurochem Res. 2017 Jun;42(6):1845-1846.
Cheong I, Marjańska M, Deelchand DK, Eberly LE, Walk D, Öz G. Ultra-High Field Proton MR Spectroscopy in Early-Stage Amyotrophic Lateral Sclerosis. Neurochem Res. 2017 Jun;42(6):1833-1844. Erratum in: Neurochem Res. 2017 Jun;42(6):1845-1846. PMCID: PMC5488866
Terpstra M, Cheong I, Lyu T, Deelchand DK, Emir UE, Bednařík P, Eberly LE, Öz G. Test-retest reproducibility of neurochemical profiles with short-echo, single-voxel MR spectroscopy at 3T and 7T. Magn Reson Med. 2016 Oct;76(4):1083-91. PMCID: PMC4846596