I am currently studying Etv2 and its role in specifying and driving the hematoendothealial lineage during development. I am focused in identifying a pioneer role of Etv2 during development and how it can potentially help reprogram cells and drive lineages for the purpose of further enhancing regenerative medicine therapies.
Singh BN, Gong W, Das S, Theisen JWM, Sierra-Pagan JE, Yannopoulos D, Skie E, Shah P, Garry MG, Garry DJ. Etv2 transcriptionally regulates Yes1 and promotes cell proliferation during embryogenesis. Sci Rep. 2019 Jul 5;9(1):9736. PMCID: PMC6611806
Work prior to the UMN MSTP:
Gerena Y, Menéndez-Delmestre R, Delgado-Nieves A, Vélez J, Méndez-Álvarez J, Sierra-Pagan JE, Skolasky RL, Henderson L, Nath A, Wojna V. Release of Soluble Insulin Receptor From Neurons by Cerebrospinal Fluid From Patients With Neurocognitive Dysfunction and HIV Infection. Front Neurol. 2019 Mar 26;10:285. PMCID: PMC6443904
Poleshko A, Shah PP, Gupta M, Babu A, Morley MP, Manderfield LJ, Ifkovits JL, Calderon D, Aghajanian H, Sierra-Pagán JE, Sun Z, Wang Q, Li L, Dubois NC, Morrisey EE, Lazar MA, Smith CL, Epstein JA, Jain R. Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction. Cell. 2017 Oct 19;171(3):573-587.e14. PMCID: PMC5683101